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神经精神性狼疮相关抗体及其诊断价值

尤含笑 李梦涛 张奉春 曾小峰 胡朝军

尤含笑, 李梦涛, 张奉春, 曾小峰, 胡朝军. 神经精神性狼疮相关抗体及其诊断价值[J]. 协和医学杂志, 2020, 11(3): 264-269. doi: 10.3969/j.issn.1674-9081.20200043
引用本文: 尤含笑, 李梦涛, 张奉春, 曾小峰, 胡朝军. 神经精神性狼疮相关抗体及其诊断价值[J]. 协和医学杂志, 2020, 11(3): 264-269. doi: 10.3969/j.issn.1674-9081.20200043
Han-xiao YOU, Meng-tao LI, Feng-chun ZHANG, Xiao-feng ZENG, Chao-jun HU. Autoantibodies Involved in Neuropsychiatric Systemic Lupus Erythematosus and Its Diagnostic Value[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 264-269. doi: 10.3969/j.issn.1674-9081.20200043
Citation: Han-xiao YOU, Meng-tao LI, Feng-chun ZHANG, Xiao-feng ZENG, Chao-jun HU. Autoantibodies Involved in Neuropsychiatric Systemic Lupus Erythematosus and Its Diagnostic Value[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 264-269. doi: 10.3969/j.issn.1674-9081.20200043

神经精神性狼疮相关抗体及其诊断价值

doi: 10.3969/j.issn.1674-9081.20200043
基金项目: 

国家重点研发计划 2019YFC0840603

国家自然科学基金 81771780

中国医学科学院医学与健康科技创新工程 2017-I2M-3-001

详细信息
    通讯作者:

    胡朝军  电话:010-69159966, E-mail:huchaojun818@qq.com

  • 中图分类号: R593.24

Autoantibodies Involved in Neuropsychiatric Systemic Lupus Erythematosus and Its Diagnostic Value

More Information
  • 摘要: 神经精神性狼疮(neuropsychiatric systemic lupus erythematosus, NPSLE)是系统性红斑狼疮(systemic lupus erythematosus, SLE)病变累及神经系统而产生神经和/或精神症状的一组预后差、死亡率高的严重并发症, SLE患者血清或脑脊液中检测到的独特的自身抗体与神经精神疾病相关。在SLE患者中, NPSLE的患病率从17%至75%不等。本文论述国内外最新研究结果, 着重探讨抗核糖体P抗体、抗磷脂抗体、抗神经元抗体等相关抗体在中枢神经受累的NPSLE中的研究现状及其临床价值。
    利益冲突  无
  • 表  1  NPSLE自身抗体靶点及其相关临床表现

    抗体 定位 靶点 神经系统表现 参考文献
    抗非特异性细胞成分抗体
      抗核糖体P抗体 血清/脑脊液 全身 精神病、抑郁症 [14, 16]
      抗Sm抗体 血清/脑脊液 全身 癫痫、精神病 [17]
      抗SmD1抗体 血清/脑脊液 全身 癫痫 [20]
      抗磷脂抗体 血清/脑脊液 全身 癫痫、舞蹈病、痴呆、精神病、抑郁症、认知功能障碍、偏头痛 [21]
    抗神经元成分抗体
      抗神经元抗体 血清 神经系统 认知功能障碍 [26-27]
      抗NR2抗体 血清/脑脊液 神经系统 认知功能障碍、抑郁症 [28, 33-34]
      抗神经节甙抗体 血清/脑脊液 神经系统 偏头痛、认知功能障碍、抑郁症、周围神经病变 [35]
      抗γ-氨基丁酸受体抗体 血清/脑脊液 神经系统 急性混乱状态 [9]
      抗胶质纤维酸性蛋白抗体 血清 神经系统 器质性脑病表现 [39]
      抗微管相关蛋白-2抗体 血清 神经系统 精神病、癫痫、神经病、脑炎 [40]
    抗内皮细胞抗体 血清/脑脊液 全身 精神病、抑郁症 [42]
    NPSLE:神经精神性狼疮
    下载: 导出CSV
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  • 收稿日期:  2020-02-23
  • 刊出日期:  2020-05-30

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