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摘要: 外周血免疫球蛋白G4(immunoglobulin G4, IgG4)异常升高以及病变组织中大量IgG4阳性浆细胞浸润是IgG4相关性疾病(IgG4 related disease, IgG4-RD)最显著的临床病理特征。IgG4-RD临床表现多样，病变几乎可以累及任何组织/器官，已引起学者们的广泛关注。随着研究的深入，发现IgG4表达异常不仅可引起IgG4-RD，作为一种免疫反应负向调控因子，IgG4与恶性肿瘤的发生与预后、肿瘤免疫均有一定相关性。本文回顾了IgG4与恶性肿瘤的关系及其在肿瘤免疫中的作用进展。Abstract: Abnormal elevation of serum immunoglobulin G4 (IgG4) and abundant infiltration of IgG4-positive plasma cells in diseased tissues are the most common clinicopathological features of IgG4-related disease (IgG4-RD). It can affect almost any tissue and organ, and has a variety of clinical manifestations. Increasing studies have found that as a member of IgG family that negatively regulates immune response, IgG4 is correlated with the occurrence and prognosis of malignant tumors and with tumor immunity. This paper reviewed the relationship between IgG4 and malignant tumors and the role of IgG4 in tumor immunity.
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Key words:
- immunoglobulin G4 /
- immunoglobulin G4-related disease /
- malignant tumors /
- tumor immunity
作者贡献：刘乔飞、廖泉共同参与综述选题、文献检索、分析及论文撰写。利益冲突：无 -
表 1 IgG4-RD患者恶性肿瘤发生率文献回顾
参考文献 年份 国家 病例数(n) 中位随访时间(月) 恶性肿瘤发生率(%) 诊断前 同时 诊断后 总体 Schneider等[4] 2017 德国 28 未知 0 0 21.43 21.43 Hart等[11] 2012 国际多中心 978 未知 0 0 5.80 5.80 Shiokawa等[12] 2013 日本 108 40 0 0 13.90 13.90 Gupta等[13] 2013 美国 84 49 0 0 2.40 2.40 Ikeura等[14] 2014 日本 63 62 0 0 4.76 4.76 Hirano等[15] 2014 日本 126 73 0 5.83 13.28 19.11 Huggett等[16] 2014 英国 115 33 3.53 1.74 7.00 12.27 Buijs等[17] 2015 日本 100 74 0 0 8.00 8.00 Shimizu等[18] 2015 美国 84 54 5.56 0 11.11 16.67 Hart等[19] 2014 美国 116 43 10.30 0 10.00 20.30 Yamamoto等[20] 2012 日本 106 37 0 0 10.40 10.40 日本IgG4相关眼病研究小组[21] 2013 日本 264 未知 0 0 11.40 11.40 Asano等[22] 2015 日本 158 72 0 0 21.52 21.52 冯云路等[23] 2016 中国 272 24 1.47 0 1.86 3.33 Ahn等[24] 2017 韩国 118 未知 5.93 3.39 0.85 10.17 IgG4-RD: 免疫球蛋白G4相关性疾病 
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