邮件订阅 RSS

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

精准医疗时代下生物样本库的建设与发展特点

刘艳红,  叶庆

downloadPDF
文章导航 > 协和医学杂志  > 2021 >  12(2): 254-259
刘艳红, 叶庆. 精准医疗时代下生物样本库的建设与发展特点[J]. 协和医学杂志, 2021, 12(2): 254-259. doi: 10.3969/j.issn.1674-9081.2020.00.008
引用本文: 刘艳红, 叶庆. 精准医疗时代下生物样本库的建设与发展特点[J]. 协和医学杂志, 2021, 12(2): 254-259. doi: 10.3969/j.issn.1674-9081.2020.00.008
shu
LIU Yan-hong, YE Qing. The Characteristics of the Construction and Development of Biobank in the Era of Precision Medicine[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 254-259. doi: 10.3969/j.issn.1674-9081.2020.00.008
Citation: LIU Yan-hong, YE Qing. The Characteristics of the Construction and Development of Biobank in the Era of Precision Medicine[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 254-259. doi: 10.3969/j.issn.1674-9081.2020.00.008
shu

精准医疗时代下生物样本库的建设与发展特点

doi: 10.3969/j.issn.1674-9081.2020.00.008
  • 1.

    南京大学医学院附属鼓楼医院病理科，南京 210008

  • 2.

    南京大学医学院附属鼓楼医院生物样本库，南京 210008

  • 3.

    中国科学技术大学附属第一医院临床病理中心，合肥 230036

  • 4.

    中国科学技术大学附属第一医院智慧病理学研究所，合肥 230036

基金项目: 

江苏省重大疾病生物资源样本库妇产疾病子库 BM2015004

江苏省重大疾病生物资源样本库开放课题 SBK202006001

江苏省重大疾病生物资源样本库开放课题 SBK202006002

江苏省重大疾病生物资源样本库开放课题 SBK202006003

详细信息
    通讯作者:

    叶 庆  电话：0551-62284887，E-mail: qingye1998@126.com

  • 中图分类号: R446.9

The Characteristics of the Construction and Development of Biobank in the Era of Precision Medicine

  • 1.

    Department of Pathology, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

  • 2.

    Biobank, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

  • 3.

    Department of Pathology, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230036, China

  • 4.

    Intelligent Pathology Institute, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230036, China

Funds: 

Jiangsu Biobank of Clinical Resources BM2015004

Jiangsu Biobank of Clinical Resources Open Project SBK202006001

Jiangsu Biobank of Clinical Resources Open Project SBK202006002

Jiangsu Biobank of Clinical Resources Open Project SBK202006003

More Information

    摘要
  • 摘要: 近年来，在"健康中国"大背景下，精准医疗和生物样本库迎来了快速发展的黄金时期。精准医疗时代，生物样本库作为医疗行业的新兴领域，有其自身发展趋势和特点，表现为发展进程需标准化和规范化、高度依赖信息化建设、离不开多中心联盟和资源共享、需多学科融合支撑等。随着精准医学的不断发展，生物样本库已从生物样本和信息资源的整合平台，逐步发展为精准医疗研究的支撑服务平台及成果转化的合作平台。此外，生物样本库发展进程中尚存在数据安全、隐私保护及可持续发展运营等问题，亟待规范和完善。
    Abstract: In recent years, in the context of "Healthy China", precision medicine and biobanks have ushered in a golden period of rapid development. In the era of precision medicine, as an emerging field in the medical industry, biobanks have their own development trend and characteristics: the development process needs standardization, highly relies on information technology, is inseparable from multi-center alliance and resource sharing, and needs the support of multidisciplinary integration. With the continuous development of precision medicine, biobanks developed from its infancy stage, a platform of biological samples and information resource integration, into a service platform of precision medical study support and a platform of transformation cooperation. In addition, during the development stage of biobanks, there are problems of data security, privacy protection and sustainable operation.
    作者贡献：刘艳红负责文献资料查询及文章撰写；叶庆负责选题及审校。
    利益冲突：  无
    • HTML全文

  • 图  1  生物样本库发展阶段示意图

    下载: 全尺寸图片 幻灯片
    • 参考文献(14)
  • [1] National Research Council of the National Academies. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease[M]. Washington (DC): the National Academies Press, 2011.
    [2] McGrath S, Ghersi D. Building towards precision medicine: empowering medical professionals for the next revolution[J]. BMC Med Genomics, 2016, 9: 23. doi:  10.1186/s12920-016-0183-8
    [3] 徐鹏辉. 美国启动精准医疗计划[J]. 世界复合医学, 2015, 1: 44-46. https://www.cnki.com.cn/Article/CJFDTOTAL-SJFH201501010.htm

    Xu PH. United States Launched Precision Medicine Initiative[J]. Shi Jie Fu He Yi Xue, 2015, 1: 44-46. https://www.cnki.com.cn/Article/CJFDTOTAL-SJFH201501010.htm
    [4] 吕霁航, 赵丹惠, 韩亮. 精准医疗的研究进展[J]. 中国实验诊断学, 2017, 21: 152-154. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD201701059.htm
    [5] Thomas A, Pommier Y. Targeting Topoisomerase I in the Era of Precision Medicine[J]. Clin Cancer Res, 2019, 25: 6581-6589. doi:  10.1158/1078-0432.CCR-19-1089
    [6] Jin N, Bi AW, Lan XJ, et al. Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer[J]. Nat Commun, 2019, 10: 2701. doi:  10.1038/s41467-019-10427-2
    [7] Büttner R, Gosney JR, Skov BG, et al. Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer[J]. J Clin Oncol, 2017, 35: 3867-3876. doi:  10.1200/JCO.2017.74.7642
    [8] Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial[J]. Lancet, 2016, 387: 1540-1550. doi:  10.1016/S0140-6736(15)01281-7
    [9] Wolchok JD, Chiarion-Sileni V, Gonzalez R, et al. Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma[J]. N Engl J Med, 2017, 377: 1345-1356. doi:  10.1056/NEJMoa1709684
    [10] HOMME DP. Dynamics of China's provincial-level specialization in strategic emerging industries[J]. Res Policy, 2016, 45: 1586-1603. doi:  10.1016/j.respol.2016.03.022
    [11] 郜恒骏, 杜莉利, 张小燕, 等. 生物样本库发展的现状、机遇与挑战[J]. 协和医学杂志, 2018, 9: 172-176. doi:  10.3969/j.issn.1674-9081.2018.02.013

    Gao HJ, Du LL, Zhang XY, et al. Status, Opportunities and Challenges of Biobanks[J]. Xie He Yi Xue Za Zhi, 2018, 9: 172-176. doi:  10.3969/j.issn.1674-9081.2018.02.013
    [12] 国务院. "十三五"国家战略性新兴产业发展规划[EB/OL]. (2016-11-29). http://www.gov.cn/zhengce/content/2016-12/19/content_5150090.htm.
    [13] 白莉华, 申锷, 杨军, 等. 生物样本库大数据的伦理与法律问题研究[J]. 中国医学伦理学, 2017, 30: 1206-1212. https://www.cnki.com.cn/Article/CJFDTOTAL-XNLX201710005.htm

    Bai LH, Shen E, Yang J, et al. Analysis on the Ethical and Legal Issues of Big Data of Biobank[J]. Zhongguo Yi Xue Lun Li Xue, 2017, 30: 1206-1212. https://www.cnki.com.cn/Article/CJFDTOTAL-XNLX201710005.htm
    [14] 杨咪, 杨小丽. 理性审视精准医疗发展中的问题及其对策探讨[J]. 中国全科医学, 2017, 20: 886-890. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201707030.htm

    Yang M, Yang XL. Problems in the Development of Precision Medicine and Corresponding Countermeasures[J]. Zhongguo Quan Ke Yi Xue, 2017, 20: 886-890. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201707030.htm
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
图(1)
计量
  • 文章访问数:  682
  • HTML全文浏览量:  81
  • PDF下载量:  101
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-06-26
  • 录用日期:  2020-01-13
  • 网络出版日期:  2020-08-11
  • 刊出日期:  2021-05-30

目录

    /

    返回文章
    返回
    友情链接: 国家卫生健康委员会 北京协和医院 中国医学科学院 学术不端检测系统 国际知识资源总库 中国知网 术语在线 中国全科医学
    地址：北京市东城区帅府园1号 北京协和医院老楼7号楼
    3层302室 《协和医学杂志》编辑部
    电话：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    期刊网站版权所有：《协和医学杂志》编辑部
    京ICP备 11002662

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计

    x 关闭 永久关闭

    【温馨提醒】近日，《协和医学杂志》编辑部接到作者反映，有多名不法人员冒充期刊编辑发送见刊通知，鼓动作者添加微信，从而骗取版面费的行为。特提醒您，本刊与作者联系的方式均为邮件通知或电话，稿件进度通知邮箱为：mjpumch@126.com，编辑部电话为：010-69154261，请提高警惕，谨防上当受骗！如有任何疑问，请致电编辑部核实。谢谢！