邮件订阅 RSS

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

急性心肌梗死后心肌内出血

王亮,  沈珠军

downloadPDF
文章导航 > 协和医学杂志  > 2020 >  11(2): 170-173
王亮, 沈珠军. 急性心肌梗死后心肌内出血[J]. 协和医学杂志, 2020, 11(2): 170-173. doi: 10.3969/j.issn.1674-9081.20190263
引用本文: 王亮, 沈珠军. 急性心肌梗死后心肌内出血[J]. 协和医学杂志, 2020, 11(2): 170-173. doi: 10.3969/j.issn.1674-9081.20190263
shu
Liang WANG, Zhu-jun SHEN. Intramyocardial Haemorrhage after Acute Myocardial Infarction[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 170-173. doi: 10.3969/j.issn.1674-9081.20190263
Citation: Liang WANG, Zhu-jun SHEN. Intramyocardial Haemorrhage after Acute Myocardial Infarction[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 170-173. doi: 10.3969/j.issn.1674-9081.20190263
shu

急性心肌梗死后心肌内出血

doi: 10.3969/j.issn.1674-9081.20190263

  • 中国医学科学院 北京协和医学院 北京协和医院心内科, 北京 100730

详细信息
    通讯作者:

    沈珠军 电话:010-69155425, E-mail:zhujun66shen@126.com

  • 中图分类号: R542.2+2;R-1

Intramyocardial Haemorrhage after Acute Myocardial Infarction

  • Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 在急性心肌梗死患者中, 通过经皮冠状动脉介入治疗进行血管重建能够有效降低死亡率。然而, 即使成功开通了心外膜血管, 仍有相当比例的急性心肌梗死患者发展为慢性心力衰竭。研究发现, 冠状动脉微血管阻塞引起的"无复流"现象及随后出现的心肌内出血是参与此过程的重要因素。了解心肌内出血在"无复流"现象和心肌损伤中的作用, 对制定新的急性心肌梗死治疗策略至关重要。本文将对心肌内出血的病理生理学、影像学、临床意义和治疗策略等最新进展进行综述。
    Abstract: In patients with acute myocardial infarction, mechanical revascularization by percutaneous coronary intervention can effectively reduce mortality. However, a substantial proportion of patients with acute myocardial infarction develop chronic cardiac failure, despite restoration of epicardial vessel patency. It is found that the phenomenon of "no-reflow" caused by coronary microvascular obstruction and the subsequent myocardial hemorrhage are the important factors involved in this process. Understanding of the role of intramyocardial haemorrhage in the no-reflow phenomenon and myocardial injury is crucial to the development of new therapeutic strategies to treat acute myocardial infarction. In this article, we reviewed the latest development in pathophysiology, imaging, clinical significance, and therapeutic strategies of intramyocardial hemorrhage.
    利益冲突  无
    • HTML全文
    • 参考文献(37)
  • [1] Nabel EG, Braunwald E. A tale of coronary artery disease and myocardial infarction[J]. N Engl J Med, 2012, 366:54-63. doi:  10.1056/NEJMra1112570
    [2] Levi F, Lucchini F, Negri E, et al. Trends in mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world[J]. Heart, 2002, 88:119-124. doi:  10.1136/heart.88.2.119
    [3] Wu X, Mintz GS, Xu K, et al. The relationship between attenuated plaque identified by intravascular ultrasound and no-reflow after stenting in acute myocardial infarction:the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial[J]. JACC Cardiovasc Interv, 2011, 4:495-502. http://www.ncbi.nlm.nih.gov/pubmed/21596321
    [4] Robbers LF, Eerenberg ES, Teunissen PF, et al. Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage[J]. Eur Heart J, 2013, 34:2346-2353. doi:  10.1093/eurheartj/eht100
    [5] Ganame J, Messalli G, Dymarkowski S, et al. Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction[J]. Eur Heart J, 2009, 30:1440-1449. doi:  10.1093/eurheartj/ehp093
    [6] Jennings RB, Sommers HM, Smyth GA, et al. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog[J]. Arch Pathol, 1960, 70:68-78. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=10.1177/000331979004100304
    [7] Kloner RA, Ganote CE, Jennings RB. The no-reflow phenomenon after temporary coronary occlusion in the dog[J]. J Clin Invest, 1974, 54:1496-1508. doi:  10.1172/JCI107898
    [8] Mathey DG, Schofer J, Kuck KH, et al. Transmural, haemorrhagic myocardial infarction after intracoronary strepto-kinase. Clinical, angiographic, and necropsy findings[J]. Br Heart J, 1982, 48:546-551. doi:  10.1136/hrt.48.6.546
    [9] Kali A, Tang RL, Kumar A, et al. Detection of acute reperfusion myocardial hemorrhage with cardiac MR imaging:T2 versus T2*[J]. Radiology, 2013, 269:387-395. doi:  10.1148/radiol.13122397
    [10] McNamara JJ, Lacro RV, Yee M, et al. Hemorrhagic infarction and coronary reperfusion[J]. J Thorac Cardiovasc Surg, 1981, 81:498-501. doi:  10.1016/S0022-5223(19)39478-4
    [11] Driesen RB, Zalewski J, Vanden Driessche N, et al. Histological correlate of a cardiac magnetic resonance imaged microvascular obstruction in a porcine model of ischemia-reperfusion[J]. Cardiovasc Pathol, 2012, 21:129-131. doi:  10.1016/j.carpath.2011.07.008
    [12] Braunwald E, Kloner RA. Myocardial reperfusion:a double-edged sword?[J] J Clin Invest, 1985, 76:1713-1719. doi:  10.1172/JCI112160
    [13] Zaman AK, French CJ, Spees JL, et al. Vascular rhexis in mice subjected to non-sustained myocardial ischemia and its therapeutic implications[J]. Exp Biol Med (Maywood), 2011, 236:598-603. doi:  10.1258/ebm.2011.011026
    [14] Fishbein MC, Y-Rit J, Lando U, et al. The relationship of vascular injury and myocardial hemorrhage to necrosis after reperfusion[J]. Circulation, 1980, 62:1274-1279. doi:  10.1161/01.CIR.62.6.1274
    [15] Reffelmann T, Kloner RA. Microvascular reperfusion injury:rapid expansion of anatomic no reflow during reperfusion in the rabbit[J]. Am J Physiol Heart Circ Physiol, 2002, 283:H1099- H1107. doi:  10.1152/ajpheart.00270.2002
    [16] Marra MP, Cacciavillani L, Corbetti F, et al. The contribution of intramyocardial hemorrhage to the "no-reflow phenomenon":a study performed by cardiac magnetic resonance[J]. Echocardiography, 2010, 27:1120-1129. doi:  10.1111/j.1540-8175.2010.01213.x
    [17] Bulluck H, Dharmakumar R, Arai AE, et al. Cardiovascular Magnetic Resonance in Acute ST-Segment-Elevation Myocardial Infarction:Recent Advances, Controversies, and Future Directions[J]. Circulation, 2018, 137:1949-1964. doi:  10.1161/CIRCULATIONAHA.117.030693
    [18] 周慷, 石海峰, 苏佰燕, 等.磁共振引导聚焦超声:现状与前景[J].协和医学杂志, 2020, 11:1-5. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=XHYX202001002
    [19] O'Regan DP, Ariff B, Neuwirth C, et al. Assessment of severe reperfusion injury with T2* cardiac MRI in patients with acute myocardial infarction[J]. Heart, 2010, 96:1885-1891. doi:  10.1136/hrt.2010.200634
    [20] Hamirani YS, Wong A, Kramer CM, et al. Effect of microvascular obstruction and intramyocardial hemorrhage by CMR on LV remodeling and outcomes after myocardial infarction:a systematic review and meta-analysis[J]. JACC Cardiovasc Imaging, 2014, 7:940-952. doi:  10.1016/j.jcmg.2014.06.012
    [21] Bulluck H, Rosmini S, Abdel-Gadir A, et al. Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST- segment elevation myocardial infarction (STEMI) patients[J]. J Magn Reson Imaging, 2017, 46:877-886. doi:  10.1002/jmri.25638
    [22] Kali A, Cokic I, Tang R, et al. Persistent microvascular obstruction after myocardial infarction culminates in the confluence of ferric iron oxide crystals, proinflammatory burden, and adverse remodeling[J]. Circ Cardiovasc Imaging, 2016, 9.pii:e004996. http://www.ncbi.nlm.nih.gov/pubmed/27903536
    [23] Bulluck H, Rosmini S, Abdel-Gadir A, et al. Residual myocardial iron following intramyocardial hemorrhage during the convalescent phase of reperfused ST-segment-elevation myocardial infarction and adverse left ventricular remodeling[J]. Circ Cardiovasc Imaging, 2016, 9. pii:e004940. http://europepmc.org/articles/PMC5068185/
    [24] Carberry J, Carrick D, Haig C, et al. Persistent iron within the infarct core after ST-segment elevation myocardial infarction:implications for left ventricular remodeling and health outcomes[J]. JACC Cardiovasc Imaging, 2018, 11:1248-1256. doi:  10.1016/j.jcmg.2017.08.027
    [25] Reinstadler SJ, Stiermaier T, Reindl M, et al. Intramyocardial haemorrhage and prognosis after ST-elevation myocardial infarction[J]. Eur Heart J Cardiovasc Imaging, 2019, 20:138-146. doi:  10.1093/ehjci/jey101
    [26] Beek AM, Nijveldt R, van Rossum AC. Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention[J]. Int J Cardiovasc Imaging, 2010, 26:49-55. doi:  10.1007/s10554-009-9499-1
    [27] Amabile N, Jacquier A, Shuhab A, et al. Incidence, predictors, and prognostic value of intramyocardial hemorrhage lesions in ST elevation myocardial infarction[J]. Catheter Cardiovasc Interv, 2012, 79:1101-1108. doi:  10.1002/ccd.23278
    [28] Stork A, Lund GK, Muellerleile K, et al. Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction[J]. Eur Radiol, 2006, 16:2350-2357. doi:  10.1007/s00330-006-0232-3
    [29] Tartan Z, Ozer N, Uyarel H, et al. Metabolic syndrome is a predictor for an ECG sign of no-reflow after primary PCI in patients with acute ST-elevation myocardial infarction[J]. Nutr Metab Cardiovasc Dis, 2008, 18:441-447. doi:  10.1016/j.numecd.2007.02.015
    [30] Amier RP, Tijssen RYG, Teunissen PFA, et al. Predictors of Intramyocardial Hemorrhage After Reperfused ST-Segment Elevation Myocardial Infarction[J]. J Am Heart Assoc, 2017, 6.pii:e005651. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586425/
    [31] Maxwell L, Gavin JB. The role of post-ischaemic reperfusion in the development of microvascular incompetence and ultrastructural damage in the myocardium[J]. Basic Res Cardiol, 1991, 86:544-553. doi:  10.1007/BF02190704
    [32] Kloner RA. Current state of clinical translation of cardioprotective agents for acute myocardial infarction[J]. Circ Res, 2013, 113:451-463. doi:  10.1161/CIRCRESAHA.112.300627
    [33] Zhang J, Ding L, Zhao Y, et al. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction[J]. Circulation, 2009, 119:1776-1784. doi:  10.1161/CIRCULATIONAHA.108.800565
    [34] Huang RL, Teo Z, Chong HC, et al. ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters[J]. Blood, 2011, 118:3990-4002. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=4bcc02c9afc451f51e06008e02cfa0bc
    [35] Sandhu R, Teichert-Kuliszewska K, Nag S, et al. Reci-procal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat[J]. Cardiovasc Res, 2004, 64:115-124. doi:  10.1016/j.cardiores.2004.05.013
    [36] Copin JC, Merlani P, Sugawara T, et al. Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats[J]. Exp Neurol, 2008, 213:196-201. doi:  10.1016/j.expneurol.2008.05.022
    [37] Betgem RP, de Waard GA, Nijveldt R, et al. Intramy-ocardial haemorrhage after acute myocardial infarction[J]. Nat Rev Cardiol, 2015, 12:156-167. doi:  10.1038/nrcardio.2014.188
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  685
  • HTML全文浏览量:  62
  • PDF下载量:  103
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-12-02
  • 刊出日期:  2020-03-30

目录

    /

    返回文章
    返回
    友情链接: 国家卫生健康委员会 北京协和医院 中国医学科学院 学术不端检测系统 国际知识资源总库 中国知网 术语在线 中国全科医学
    地址：北京市东城区帅府园1号 北京协和医院老楼7号楼
    3层302室 《协和医学杂志》编辑部
    电话：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    期刊网站版权所有：《协和医学杂志》编辑部
    京ICP备 11002662

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计

    x 关闭 永久关闭

    【温馨提醒】近日，《协和医学杂志》编辑部接到作者反映，有多名不法人员冒充期刊编辑发送见刊通知，鼓动作者添加微信，从而骗取版面费的行为。特提醒您，本刊与作者联系的方式均为邮件通知或电话，稿件进度通知邮箱为：mjpumch@126.com，编辑部电话为：010-69154261，请提高警惕，谨防上当受骗！如有任何疑问，请致电编辑部核实。谢谢！