磁共振引导聚焦超声在中枢神经系统疾病中的应用

张蕊; 白岩; 魏巍; 王梅云

doi:10.3969/j.issn.1674-9081.20190214

磁共振引导聚焦超声在中枢神经系统疾病中的应用

doi: 10.3969/j.issn.1674-9081.20190214

张蕊^{1, 2, 3},
白岩^{1, 2},
魏巍^{1, 2},
王梅云^{1, 2, ,}

1.
河南省人民医院医学影像科, 郑州 450003
2.
河南省神经疾病影像诊断与研究重点实验室, 郑州 450003
3.
郑州大学医学科学院, 郑州 450000

基金项目:

国家重点研发计划 2017YFE0103600

国家自然科学基金 81720108021

国家自然科学基金 81601466

详细信息

通讯作者:
王梅云电话:0371-65580013, E-mail:marian9999@163.com

中图分类号: R445.1
计量
- 文章访问数: 500
- HTML全文浏览量: 52
- PDF下载量: 195
- 被引次数: 0
出版历程
- 收稿日期: 2019-10-08
- 刊出日期: 2020-01-30

Application of Magnetic Resonance-guided Focused Ultrasound Therapy in Central Nervous System Diseases

Rui ZHANG^{1, 2, 3},
Yan BAI^{1, 2},
Wei WEI^{1, 2},
Mei-yun WANG^{1, 2
, ,}

1.
Department of Medical Imaging, Henan Provincial People's Hospital, Zhengzhou 450003, China
2.
Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China
3.
Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China

More Information

Corresponding author: WANG Mei-yun Tel: 86-371-65580013, E-mail:marian9999@163.com

摘要

摘要: 磁共振引导聚焦超声是一种先进的无创治疗技术, 在通过靶向热消融及开放血脑屏障治疗中枢神经系统疾病方面具有较大潜力, 目前已被应用于特发性震颤、帕金森病、颅内肿瘤、阿尔兹海默病、强迫症、神经病理性疼痛等疾病的研究与治疗中。磁共振引导聚焦超声因其精准、无电离辐射、实时监测靶点温度等优势可能成为诸多疾病的潜在替代疗法, 为患者提供一种新的治疗选择。本文就目前磁共振引导聚焦超声在中枢神经系统疾病方面的临床应用及科学研究予以综述。
- 磁共振引导聚焦超声 /
- 中枢神经系统疾病 /
- 热消融 /
- 血脑屏障开放
Abstract: Magnetic resonance-guided focused ultrasound is an advanced non-invasive therapeutic technique, which has great potential in targeted thermal ablation and blood-brain barrier opening treatment of central nervous system diseases. It has been used in the research and treatment of essential tremor, Parkinson's disease, intracranial tumors, Alzheimer's disease, obsessive-compulsive disorder, neuropathic pain, and other diseases now. Magnetic resonance-guided focused ultrasound therapy may be a potential alternative therapy for many diseases due to its advantages such as precision, non-ionizing radiation, and real-time monitoring of target temperature. In this article, we reviewed the progress of magnetic resonance-guided focused ultrasound therapy in clinical applications and scientific researches.
- magnetic resonance-guided focused ultrasound /
- central nervous system disease /
- thermal ablation /
- blood-brain barrier opening
注释:

利益冲突 无

HTML全文

参考文献(72)

[1]	Kobus T, McDannold N. Update on Clinical Magnetic Resonance-Guided Focused Ultrasound Applications[J]. Magn Reson Imaging Clin N Am, 2015, 23:657-667. doi: 10.1016/j.mric.2015.05.013
[2]	金征宇, 苏佰燕, 薛华丹.磁共振引导下聚焦超声新技术进展及其临床应用[J].磁共振成像, 2014, 5:26-30. http://www.cnki.com.cn/Article/CJFDTotal-CGZC2014S1008.htm
[3]	苏佰燕, 薛华丹, 金征宇.子宫肌瘤的影像诊断及与影像医学相关的治疗[J].协和医学杂志, 2011, 2:273-276. http://d.wanfangdata.com.cn/Periodical/xhyx201103017
[4]	Meng Y, Suppiah S, Mithani K, et al. Current and emerging brain applications of MR-guided focused ultrasound[J]. J Ther Ultrasound, 2017, 5:26. doi: 10.1186/s40349-017-0105-z
[5]	Louis ED, Ferreira JJ. How common is the most common adult movement disorder:update on the worldwide prevalence of essential tremor[J]. Mov Disord, 2010, 25:534-541. doi: 10.1002/mds.22838
[6]	Chandran V, Pal PK, Reddy JYC, et al. Non-motor features in essential tremor[J]. Acta Neurol Scand, 2012, 125:332-337. doi: 10.1111/j.1600-0404.2011.01573.x
[7]	Lundervold DA, Ament PA, Holt P. Social anxiety, tremor severity, and tremor disability:a search for clinically relevant measures[J]. Psychiatry J, 2013, 2013:257459. doi: 10.1155/2013/257459
[8]	Lorenz D, Poremba C, Papengut F, et al. The psychosocial burden of essential tremor in an outpatient-and a community-based cohort[J]. Eur J Neurol, 2011, 18:972-979. doi: 10.1111/j.1468-1331.2010.03295.x
[9]	毛成洁, 陈菊萍, 胡伟东, 等.运动障碍疾病伴发抑郁的临床观察[J].中华医学杂志, 2013, 93:26-29. http://www.cqvip.com/QK/93850X/201301/44534208.html
[10]	Haubenberger D, Hallett M. Essential Tremor[J]. N Engl J Med, 2018, 378:1802-1810. doi: 10.1056/NEJMcp1707928
[11]	Elias WJ, Shah BB. Tremor[J]. JAMA, 2014, 311:948-954. doi: 10.1001/jama.2014.1397
[12]	Elias WJ, Khaled M, Hilliard JD, et al. A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus[J]. J Neurosurg, 2013, 119:307-317. doi: 10.3171/2013.5.JNS122327
[13]	Shanker V. Essential tremor:diagnosis and management.[J]. BMJ, 2019, 366:l4485. https://pubmed.ncbi.nlm.nih.gov/31383632/
[14]	Elias WJ, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor[J]. N Engl J Med, 2013, 369:640-648. doi: 10.1056/NEJMoa1300962
[15]	Lipsman N, Schwartz ML, Huang Y, et al. MR-guided focused ultrasound thalamotomy for essential tremor:a proof-of-concept study[J]. Lancet Neurol, 2013, 12:462-468. doi: 10.1016/S1474-4422(13)70048-6
[16]	Chang WS, Jung HH, Kweon EJ, et al. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor:practices and clinicoradiological outcomes[J]. J Neurol Neurosurg Psychiatry, 2015, 86:257-264. doi: 10.1136/jnnp-2014-307642
[17]	Elias WJ, Lipsman N, Ondo WG, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor[J]. N Engl J Med, 2016, 375:730-739. doi: 10.1056/NEJMoa1600159
[18]	Fishman PS. Thalamotomy for essential tremor:FDA approval brings brain treatment with FUS to the clinic[J]. J Ther Ultrasound, 2017, 5:19. doi: 10.1186/s40349-017-0096-9
[19]	Iacopino DG, Gagliardo C, Giugno A, et al. Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson's disease[J]. Neurosurg Focus, 2018, 44:E7. http://www.ncbi.nlm.nih.gov/pubmed/29385927
[20]	Jung NY, Park CK, Chang WS, et al. Effects on cognition and quality of life with unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor[J]. Neurosurg Focus, 2018, 44:E8. https://pubmed.ncbi.nlm.nih.gov/29385928/
[21]	Zaaroor M, Sinai A, Goldsher D, et al. Magnetic resonance-guided focused ultrasound thalamotomy for tremor:a report of 30 Parkinson's disease and essential tremor cases[J]. J Neurosurg, 2018, 128:202-210. doi: 10.3171/2016.10.JNS16758
[22]	宗睿, 何建风, 张德康, 等.磁共振引导超声聚焦系统("磁波刀")在治疗特发性震颤中的应用[J].解放军医学院学报, 2019, 40:1-6. http://www.cqvip.com/Main/Detail.aspx?id=74897488504849574849484850
[23]	Fishman PS, Elias WJ, Ghanouni P, et al. Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor[J]. Mov Disord, 2018, 33:843-847. doi: 10.1002/mds.27401
[24]	Chang JW, Park CK, Lipsman N, et al. A prospective trial of magnetic resonance-guided focused ultrasound thalamo-tomy for essential tremor:Results at the 2-year follow-up[J]. Ann Neurol, 2018, 83:107-114. doi: 10.1002/ana.25126
[25]	Sinai A, Nassar M, Eran A, et al. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor:a 5-year single-center experience[J]. J Neurosurg, 2019, 1:1-8. http://www.researchgate.net/publication/339290667_Erratum_Magnetic_resonance-guided_focused_ultrasound_thalamotomy_for_essential_tremor_a_5-year_single-center_experience
[26]	Schlesinger I, Eran A, Sinai A, et al. MRI guided focused ultrasound thalamotomy for moderate-to-severe tremor in Parkinson's disease[J]. Parkinsons Dis, 2015, 2015:219149. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572440/
[27]	Bond AE, Shah BB, Huss DS, et al. Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson disease:a randomized clinical trial[J]. JAMA Neurol, 2017, 74:1412-1418. doi: 10.1001/jamaneurol.2017.3098
[28]	Fasano A, Llinas M, Munhoz RP, et al. MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes[J]. Neurology, 2017, 89:771-775. doi: 10.1212/WNL.0000000000004268
[29]	史俊庭, 崔冰心.河南完成大陆地区首例帕金森病震颤磁波刀治疗[EB/OL]. http://news.sciencenet.cn/htmlnews/2019/3/423392.shtm.
[30]	Magara A, Bühler R, Moser D, et al. First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease[J]. J Ther Ultrasound, 2014, 2:11. doi: 10.1186/2050-5736-2-11
[31]	Na YC, Chang WS, Jung HH, et al. Unilateral magnetic resonance-guided focused ultrasound pallidotomy for Parkinson disease[J]. Neurology, 2015, 85:549-551. doi: 10.1212/WNL.0000000000001826
[32]	Jung NY, Park CK, Kim M, et al. The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson's disease:a Phase I clinical trial[J]. J Neurosurg, 2018, 1:1-9. https://thejns.org/downloadpdf/journals/j-neurosurg/130/6/article-p1853.xml
[33]	Martínez-Fernández R, Rodríguez-Rojas R, del Álamo M, et al. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease:a pilot study[J]. Lancet Neurol, 2018, 17:54-63. doi: 10.1016/S1474-4422(17)30403-9
[34]	Yang FY, Horng SC. Ultrasound enhanced delivery of macromolecular agents in brain tumor rat model[C]. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011: 5573-5576.
[35]	Burgess A, Hynynen K. Noninvasive and targeted drug delivery to the brain using focused ultrasound[J]. ACS Chem Neurosci, 2013, 4:519-526. doi: 10.1021/cn300191b
[36]	Fan CH, Ting CY, Lin CY, et al. Noninvasive, targeted, and non-viral ultrasound-mediated GDNF-plasmid delivery for treatment of Parkinson's disease[J]. Sci Rep, 2016, 6:19579. doi: 10.1038/srep19579
[37]	Mead BP, Kim N, Miller GW, et al. Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat Parkinson's disease model[J]. Nano Lett, 2017, 17:3533-3542. doi: 10.1021/acs.nanolett.7b00616
[38]	Meng Y, Voisin MR, Suppiah S, et al. Is there a role for MR-guided focused ultrasound in Parkinson's disease?[J]. Mov Disord, 2018, 33:575-579. doi: 10.1002/mds.27308
[39]	Mainprize T, Lipsman N, Huang Y, et al. Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound:a clinical safety and feasibility study[J]. Sci Rep, 2019, 9:321. doi: 10.1038/s41598-018-36340-0
[40]	Rochet NM, Dronca RS, Kottschade LA, et al. Melanoma brain metastases and vemurafenib:need for further investigation[J]. Mayo Clin Proc, 2012, 87:976-981. doi: 10.1016/j.mayocp.2012.07.006
[41]	Wei KC, Chu PC, Wang HYJ, et al. Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment:a preclinical study[J]. PLoS One, 2013, 8:e58995. doi: 10.1371/journal.pone.0058995
[42]	Kobus T, Zervantonakis IK, Zhang Y, et al. Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption[J]. J Control Release, 2016, 238:281-288. doi: 10.1016/j.jconrel.2016.08.001
[43]	Treat LH, McDannold N, Zhang Y, et al. Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma[J]. Ultrasound Med Biol, 2012, 38:1716-1725. doi: 10.1016/j.ultrasmedbio.2012.04.015
[44]	Alli S, Figueiredo CA, Golbourn B, et al. Brainstem blood brain barrier disruption using focused ultrasound:A demonstration of feasibility and enhanced doxorubicin delivery[J]. J Control Release, 2018, 281:29-41. doi: 10.1016/j.jconrel.2018.05.005
[45]	Carpentier A, Canney M, Vignot A, et al. Clinical trial of blood-brain barrier disruption by pulsed ultrasound[J]. Sci Transl Med, 2016, 8:343re2. doi: 10.1126/scitranslmed.aaf6086
[46]	Idbaih A, Canney M, Belin L, et al. Safety and feasibility of repeated and transient blood-brain barrier disruption by pulsed ultrasound in patients with recurrent glioblastoma[J]. Clin Cancer Res, 2019, 25:3793-3801. doi: 10.1158/1078-0432.CCR-18-3643
[47]	Meng Y, Suppiah S, Surendrakumar S, et al. Low-intensity MR-guided focused ultrasound mediated disruption of the blood-brain barrier for intracranial metastatic diseases[J]. Front Oncol, 2018, 8:338. doi: 10.3389/fonc.2018.00338
[48]	McDannold N, Clement GT, Black P, et al. Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors:initial findings in 3 patients[J]. Neurosurgery, 2010, 66:323-332. doi: 10.1227/01.NEU.0000360379.95800.2F
[49]	Coluccia D, Fandino J, Schwyzer L, et al. First noninvasive thermal ablation of a brain tumor with MR-guided focused ultrasound[J]. J Ther Ultrasound, 2014, 2:17. doi: 10.1186/2050-5736-2-17
[50]	Karakatsani ME, Kugelman T, Ji R, et al. Unilateral focused ultrasound-induced blood-brain barrier opening reduces phosphorylated tau from the rTg4510 mouse model[J]. Theranostics, 2019, 9:5396-5411. doi: 10.7150/thno.28717
[51]	Nisbet RM, Van der Jeugd A, Leinenga G, et al. Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model[J]. Brain, 2017, 140:1220-1230. doi: 10.1093/brain/awx052
[52]	Jordão JF, Ayala-Grosso CA, Markham K, et al. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-β plaque load in the TgCRND8 mouse model of Alzheimer's disease[J]. PLoS One, 2010, 5:e10549. doi: 10.1371/journal.pone.0010549
[53]	Burgess A, Dubey S, Yeung S, et al. Alzheimer disease in a mouse model:MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior[J]. Radiology, 2014, 273:736-745. doi: 10.1148/radiol.14140245
[54]	Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model[J]. Sci Transl Med, 2015, 7:278ra33. doi: 10.1126/scitranslmed.aaa2512
[55]	Li L, Xu B, Zhu Y, et al. DHEA prevents Aβ25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling[J]. Neuropharmacology, 2010, 59:323-333. doi: 10.1016/j.neuropharm.2010.02.009
[56]	Jalali S, Huang Y, Dumont DJ, et al. Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT:experimental study in rats[J]. BMC Neurol, 2010, 10:114. doi: 10.1186/1471-2377-10-114
[57]	Chen KT, Wei KC, Liu HL. Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment[J]. Front Pharmacol, 2019, 10:86. doi: 10.3389/fphar.2019.00086
[58]	Lipsman N, Meng Y, Bethune AJ, et al. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound[J]. Nat Commun, 2018, 9:2336. doi: 10.1038/s41467-018-04529-6
[59]	Meng Y, MacIntosh BJ, Shirzadi Z, et al. Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease[J]. Neuroimage, 2019, 200:275-280. doi: 10.1016/j.neuroimage.2019.06.060
[60]	Hawken E, Dilkov D, Kaludiev E, et al. Transcranial magnetic stimulation of the supplementary motor area in the treatment of obsessive-compulsive disorder:a multi-site study[J]. Int J Mol Sci, 2016, 17:420. doi: 10.3390/ijms17030420
[61]	Franklin ME, Foa EB. Treatment of obsessive compulsive disorder[J]. Annu Rev Clin Psychol, 2011, 7:229-243. doi: 10.1146/annurev-clinpsy-032210-104533
[62]	Kumar KK, Bhati MT, Ravikumar VK, et al. MR-guided Focused Ultrasound versus Radiofrequency Capsulotomy for Treatment-Refractory Obsessive Compulsive Disorder:A Cost-Effectiveness Threshold Analysis[J]. Front Neurosci, 2019, 13:66. doi: 10.3389/fnins.2019.00066
[63]	Jung HH, Kim SJ, Roh D, et al. Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder:a proof-of-concept study[J]. Mol Psychiatry, 2015, 20:1205-1211. doi: 10.1038/mp.2014.154
[64]	Kim SJ, Roh D, Jung HH, et al. A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder:2-year follow-up[J]. J Psychiatry Neurosci, 2018, 43:327-337. doi: 10.1503/jpn.170188
[65]	Kim M, Kim CH, Jung HH, et al. Treatment of major depressive disorder via magnetic resonance-guided focused ultrasound surgery[J]. Biol Psychiatry, 2018, 83:e17-e18. doi: 10.1016/j.biopsych.2017.05.008
[66]	Toth C, Lander J, Wiebe S. The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population[J]. Pain Med, 2009, 10:918-929. doi: 10.1111/j.1526-4637.2009.00655.x
[67]	Jung NY, Chang JW. Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery:Taking Lessons from the Past to Inform the Future[J]. J Korean Med Sci, 2018, 33:e279. doi: 10.3346/jkms.2018.33.e279
[68]	Lee EJ, Fomenko A, Lozano AM. Magnetic resonance-guided focused ultrasound:current status and future perspectives in thermal ablation and blood-brain barrier opening[J]. J Korean Neurosurg Soc, 2019, 62:10-26. doi: 10.3340/jkns.2018.0180
[69]	Jeanmonod D, Werner B, Morel A, et al. Transcranial magnetic resonance imaging-guided focused ultrasound:noninvasive central lateral thalamotomy for chronic neuropathic pain[J]. Neurosurg Focus, 2012, 32:E1.
[70]	Parker WE, Weidman EK, Chazen JL, et al. Magnetic resonance-guided focused ultrasound for ablation of mesial temporal epilepsy circuits:modeling and theoretical feasibility of a novel noninvasive approach[J]. J Neurosurg, 2019, 1:1-8. https://www.ncbi.nlm.nih.gov/pubmed/31200385
[71]	Ranjan M, Boutet A, Bhatia S, et al. Neuromodulation beyond neurostimulation for epilepsy:scope for focused ultrasound[J]. Expert Rev Neurother, 2019, 19:937-943. doi: 10.1080/14737175.2019.1635013
[72]	Naor O, Krupa S, Shoham S. Ultrasonic neuromodulation[J]. J Neural Eng, 2016, 13:031003. doi: 10.1088/1741-2560/13/3/031003

施引文献

资源附件(0)

访问统计

点击查看大图

计量

文章访问数: 500
HTML全文浏览量: 52
PDF下载量: 195
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

地址：	北京市东城区帅府园1号北京协和医院老楼7号楼 3层302室《协和医学杂志》编辑部
电话：	010-69154261/4262
E - mail：	medj@pumch.cn mjpumch@126.com
期刊网站版权所有：	《协和医学杂志》编辑部京ICP备 11002662

留言板

磁共振引导聚焦超声在中枢神经系统疾病中的应用

doi: 10.3969/j.issn.1674-9081.20190214

通讯作者:
王梅云电话:0371-65580013, E-mail:marian9999@163.com

计量

Application of Magnetic Resonance-guided Focused Ultrasound Therapy in Central Nervous System Diseases

Corresponding author: WANG Mei-yun Tel: 86-371-65580013, E-mail:marian9999@163.com

计量

目录

留言板

磁共振引导聚焦超声在中枢神经系统疾病中的应用

doi: 10.3969/j.issn.1674-9081.20190214

通讯作者: 王梅云 电话:0371-65580013, E-mail:marian9999@163.com

计量

出版历程

Application of Magnetic Resonance-guided Focused Ultrasound Therapy in Central Nervous System Diseases

Corresponding author: WANG Mei-yun Tel: 86-371-65580013, E-mail:marian9999@163.com

计量

出版历程

目录

通讯作者:
王梅云电话:0371-65580013, E-mail:marian9999@163.com