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Clinical Pathological Features and Prognosis of Non-small Cell Lung Cancer with Skip N2 Lymph Node Metastasis
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摘要: 肺癌作为全球肿瘤致死的首要原因, 发病率逐年上升。其主要治疗方式, 尤其对于早期非小细胞肺癌患者, 手术治疗依然占主导地位, 而淋巴结转移状态对于肺癌的分期、预后至关重要。跳跃性N2淋巴结转移比较常见, 且与患者预后密切相关。本文主要归纳非小细胞肺癌跳跃性N2淋巴结转移的临床病理特点及其预后, 以期为临床决策提供一定指导。Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the world. The main treatment is surgery intervention, especially for the early-stage of NSCLC. The pathological lymph node metastasis is closely associated with the staging and prognosis of patients. Among N2 metastasis, skip N2 metastasis is a quite common phenomenon with a better prognosis. The aim of this article is to summarize the clinical pathological features and prognosis of NSCLC with skip N2 metastasis and to guide the clinical decision making.利益冲突 无
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表 1 不同文献报道的跳跃性N2转移肺癌患者5年生存率
作者 报道年份 跳跃性N2转移 非跳跃性N2转移 P值 例数 5年生存率
(%)例数 5年生存率
(%)Yazgan[34] 2018 59 51.2 71 21.5 0.001 Akcay[35] 2017 55 20.0 56 7.4 0.084 Guerrera[12] 2017 54 42.0 225 44.0 0.840 Li[13] 2015 45 60.7 132 32.1 0.024 Sonobe[15] 2013 248 47.8 248 41.7 0.168 Ohta[32] 2006 50 33.4 44 19.8 0.019 Prenzel[28] 2004 17 41.0 28 14.0 0.019 Gawrychowski[36] 2003 23 26.1 41 0 0.002 Fukuse[37] 2000 30 51.0 57 33.0 0.120 Oyaizu[38] 1999 76 37.0 102 22.0 0.020 Yoshino[39] 1996 33 35.0 77 13.0 0.054 
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