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肠道菌群在天然免疫系统中的作用

焦禹豪,  陈蓓迪,  张烜

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文章导航 > 协和医学杂志  > 2019 >  10(3): 257-262
焦禹豪, 陈蓓迪, 张烜. 肠道菌群在天然免疫系统中的作用[J]. 协和医学杂志, 2019, 10(3): 257-262. doi: 10.3969/j.issn.1674-9081.2019.03.012
引用本文: 焦禹豪, 陈蓓迪, 张烜. 肠道菌群在天然免疫系统中的作用[J]. 协和医学杂志, 2019, 10(3): 257-262. doi: 10.3969/j.issn.1674-9081.2019.03.012
shu
Yu-hao JIAO, Bei-di CHEN, Xuan ZHANG. Interplay between the Gut Microbiota and the Innate Immune System[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 257-262. doi: 10.3969/j.issn.1674-9081.2019.03.012
Citation: Yu-hao JIAO, Bei-di CHEN, Xuan ZHANG. Interplay between the Gut Microbiota and the Innate Immune System[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 257-262. doi: 10.3969/j.issn.1674-9081.2019.03.012
shu

肠道菌群在天然免疫系统中的作用

doi: 10.3969/j.issn.1674-9081.2019.03.012

  • 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科 风湿免疫学教育部重点实验室, 北京 100730

详细信息
    通讯作者:

    张烜 电话:010-69158797, E-mail:zxpumch2003@sina.com

  • 中图分类号: R378;R593

Interplay between the Gut Microbiota and the Innate Immune System

  • Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing 100730, China

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    摘要
  • 摘要: 人体微生物群在调控黏膜局部稳态中的重要性受到广泛重视, 有关微生物群与免疫相互作用的研究在近几年亦取得了很大进展。肠道菌群作为人体微生物群的重要组成部分, 在维持肠道宿主防御和免疫耐受二者平衡方面发挥关键作用。肠道菌群失调也被众多研究证实与免疫系统改变相关。本文主要围绕肠道相关淋巴组织、天然免疫淋巴细胞和吞噬细胞等几个方面, 阐述肠道菌群在天然免疫系统中的作用。
    Abstract: The significance of microbiota in regulating mucosal homeostasis has been addressed intensively in recent years. Meanwhile, research on human microorganism communities and their interaction with the immune system has achieved great advancement. As an essential component of the human microbiota, the gut commensal flora plays a unique role in maintaining a sophisticated balance between host defense and immune tolerance. Dysbiosis of gut microbiota may result in alterations of the innate immune system via multiple strategies. This review summarizes the underlying mechanisms of the interplay between microbiota and the innate immune system, focusing on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes.
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  • 收稿日期:  2019-02-13
  • 刊出日期:  2020-09-18

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