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皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展

王诗琪 池诚 刘洁

王诗琪, 池诚, 刘洁. 皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展[J]. 协和医学杂志, 2019, 10(2): 157-161. doi: 10.3969/j.issn.1674-9081.2019.02.014
引用本文: 王诗琪, 池诚, 刘洁. 皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展[J]. 协和医学杂志, 2019, 10(2): 157-161. doi: 10.3969/j.issn.1674-9081.2019.02.014
Shi-qi WANG, Cheng CHI, Jie LIU. Advance in the Topical Medication and Physical Therapy for Cutaneous T Cell Lymphoma[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(2): 157-161. doi: 10.3969/j.issn.1674-9081.2019.02.014
Citation: Shi-qi WANG, Cheng CHI, Jie LIU. Advance in the Topical Medication and Physical Therapy for Cutaneous T Cell Lymphoma[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(2): 157-161. doi: 10.3969/j.issn.1674-9081.2019.02.014

皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展

doi: 10.3969/j.issn.1674-9081.2019.02.014
基金项目: 

米尔斯坦亚美医学基金会-皮肤病研究基金 7182127

国家人力资源和社会保障部留学人员科技活动项目择优资助基金 7182127

北京市自然科学基金 7182127

详细信息
    通讯作者:

    刘洁电话:010-69151536,E-mail: Liujie04672@pumch.cn

  • 中图分类号: R751

Advance in the Topical Medication and Physical Therapy for Cutaneous T Cell Lymphoma

More Information
  • 摘要: 皮肤T细胞淋巴瘤(cutaneous T cell lymphoma,CTCL)大多属于惰性淋巴瘤,病情进展缓慢,患者确诊时多处于疾病早期。局部用药和物理治疗在CTCL治疗中占重要地位,包括局部外用皮质类固醇激素、免疫抑制剂、维A酸,放疗及光疗等。近年来,有研究对CTCL传统局部用药和物理治疗方法的有效性和安全性进行了重新评估。同时,新型CTCL局部用药和物理治疗策略也不断涌现,如局部外用他扎罗汀、瑞喹莫特,紫外线A联合新型光敏剂的光化学疗法和光动力治疗等。本文对CTCL局部用药和物理治疗的研究进展作一综述。
    利益冲突  无
  • [1] Talpur R, Venkatarajan S, Duvic M. Mechlorethamine gel for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma[J]. Expert Rev Clin Pharmacol, 2014, 7:591-597. doi:  10.1586/17512433.2014.944500
    [2] 罗毅鑫, 刘洁.皮肤T细胞淋巴瘤靶向治疗的研究进展[J].临床皮肤科杂志, 2016, 45:814-817. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=lcpfkzz201611025
    [3] Nguyen CV, Bohjanen KA. Skin-Directed Therapies in Cutaneous T-Cell Lymphoma[J]. Dermatol Clin, 2015, 33:683-696. doi:  10.1016/j.det.2015.05.004
    [4] Zackheim HS. Treatment of patch-stage mycosis fungoides with topical corticosteroids[J]. Dermatol Ther, 2003, 16:283-287. doi:  10.1111/j.1396-0296.2003.01639.x
    [5] Liu DY, Shaath T, Rajpara AN, et al. Safe and Efficacious Use of Intralesional Steroids for the Treatment of Focally Resistant Mycosis Fungoides[J]. J Drugs Dermatol, 2015, 14:466-470. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=6e5cda89b7d0ee0f68aa357c483a291e
    [6] Lessin SR, Duvic M, Guitart J, et al. Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides[J]. JAMA Dermatol, 2013, 149:1-8. https://www.scholars.northwestern.edu/en/publications/topical-chemotherapy-in-cutaneous-t-cell-lymphoma-positive-result
    [7] Benjamin CA, Markel K, Tawa MC. Optimizing Care and Compliance for the Treatment of Mycosis Fungoides Cutaneous T-Cell Lymphoma With Mechlorethamine Gel[J]. Clin J Oncol Nurs, 2015, 19:E131-E139. doi:  10.1188/15.CJON.E131-E139
    [8] Lindahl LM, Fenger-Gron M, Iversen L. Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis[J]. J Eur Acad Dermatol Venereol, 2013, 27:163-168. doi:  10.1111/j.1468-3083.2011.04433.x
    [9] 单百卉, 李雪, 郑玉洁, 等.口服阿维A联合氮芥外用治疗老年蕈样肉芽肿1例[J].中国老年学, 2013, 33:1155-1156. doi:  10.3969/j.issn.1005-9202.2013.05.077
    [10] Lindahl LM, Fengergrøn M, Iversen L. Secondary cancers, comorbidities and mortality associated with nitrogen mustard therapy in patients with mycosis fungoides: a 30-year population-based cohort study[J]. Br J Dermatol, 2014, 170:699-704. doi:  10.1111/bjd.12620
    [11] Apisarnthanarax N, Wood GS, Stevens SR, et al. Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type[J]. Arch Dermatol, 2012, 148:613-620. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=f334ee1ba665c917e9307f107a6442a0
    [12] Macarthur KM, Jariwala N, Kim EJ, et al. Topical Carmustine as Monotherapy or as Multimodality Therapy for Folliculotropic Mycosis Fungoides[J]. Acta Derm Venereol, 2017, 97:373-374. doi:  10.2340/00015555-2551
    [13] Heisig M, Maj J, Szepietowski JC, et al. Durable remission of folliculotropic mycosis fungoides achieved with a combined topical treatment with cytarabine and carmustine[J]. Dermatol Ther, 2015, 29:15-18. http://smartsearch.nstl.gov.cn/paper_detail.html?id=abbd764765a9bcd6f5c3430610a394c2
    [14] Apisarnthanarax N, Talpur R, Ward S, et al. Tazarotene 0.1% gel for refractory mycosis fungoides lesions: an open-label pilot study[J]. J Am Acad Dermatol, 2004, 50:600-607. doi:  10.1016/j.jaad.2003.09.005
    [15] Besner MC, Roberge D, Turchin I, et al. Tazarotene 0.1% Cream as Monotherapy for Early-Stage Cutaneous T-Cell Lymphoma[J]. J Cutan Med Surg, 2016, 20:244-248. doi:  10.1177/1203475415626686
    [16] Coors EA, Von d DP. Treatment of 2 patients with mycosis fungoides with alitretinoin[J]. J Am Acad Dermatol, 2012, 67:e265-e267. doi:  10.1016/j.jaad.2012.05.011
    [17] Miernik B, Schmidt V, Technau-Hafsi K, et al. Alitretinoin in the treatment of palmoplantar mycosis fungoides: a new and promising therapeutic approach[J]. Clin Exp Dermatol, 2014, 40:445-447. https://www.ncbi.nlm.nih.gov/pubmed/25476933/
    [18] Bassiri-Tehrani S, David E. Treatment of cutaneous T-cell lymphoma with alitretinoin gel[J]. Int J Dermatol, 2002, 41:104-106. doi:  10.1046/j.1365-4362.2002.01363.x
    [19] Gordon MC, Sluzevich JC, Jambusariapahlajani A. Clearance of folliculotropic and tumor mycosis fungoides with topical 5% imiquimod[J]. JAAD Case Rep, 2015, 1:348-350. doi:  10.1016/j.jdcr.2015.08.007
    [20] Rook AH, Gelfand JC, Wysocka M, et al. Topical resiqui-mod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma[J]. Blood, 2015, 126:1452.
    [21] Killock D. Haematological cancer: Resiquimod-a topical CTCL therapy[J]. Nat Rev Clin Oncol, 2015, 126:1452-1461. http://www.nature.com/nrclinonc/journal/v12/n10/full/nrclinonc.2015.142.html
    [22] Emmilia H, Lev P. Phototherapy of Mycosis Fungoides[J]. Dermatol Clin, 2015, 33:697-702. doi:  10.1016/j.det.2015.05.005
    [23] Olsen EA, Hodak E, Anderson T, et al. Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium[J]. J Am Acad Dermatol, 2016, 74:27-58. doi:  10.1016/j.jaad.2015.09.033
    [24] Koh MJ, Chong WS. Narrow-band ultraviolet B phototherapy for mycosis fungoides in children[J]. Clin Exp Dermatol, 2014, 39:474-478. doi:  10.1111/ced.12364
    [25] Hernández Z, Peñate Y, Hernándezmachín B, et al. Treat-ment of stage Ia and Ib mycosis fungoides with psoralen UVA monotherapy: an observational study in tertiary hospitals in the Canary Islands[J]. Int J Dermatol, 2014, 53:1417-1422. doi:  10.1111/ijd.12425
    [26] Pavlotsky F, Hodak E, Ben AD, et al. Role of bath psoralen plus ultraviolet A in early-stage mycosis fungoides[J]. J Am Acad Dermatol, 2014, 71:536-541. doi:  10.1016/j.jaad.2014.04.011
    [27] 闫岩, 徐晨琛, 王涛, 等.局部甲氧沙林加紫外线A治疗难治性蕈样肉芽肿皮损的初步研究[J].中华肿瘤杂志, 2015, 37:859-862. doi:  10.3760/cma.j.issn.0253-3766.2015.11.013
    [28] Biskup E, Naym DG, Gniadecki R. Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase(ATR) sensitize lymphoma cells to UVA radiation[J]. J Dermatol Sci, 2016, 84:239-247. doi:  10.1016/j.jdermsci.2016.09.010
    [29] Olek-Hrab K, Silny W, Dańczak-Pazdrowska A, et al. Ultraviolet al phototherapy for mycosis fungoides[J]. Clin Exp Dermatol, 2013, 38:126-130. doi:  10.1111/ced.12001
    [30] Aydogan K, Yazici S, Balaban AS, et al. Efficacy of low-dose ultraviolet a-1 phototherapy for parapsoriasis/early-stage mycosis fungoides[J]. Photochem Photobiol, 2014, 91:873-877. doi:  10.1111/php.12253
    [31] Mofty ME, Ramadan S, Fawzy MM, et al. Broad band UVA: a possible reliable alternative to PUVA in the treatment of early-stage mycosis fungoides[J]. Photodermatol Photoimmunol Photomed, 2012, 28:274-277. doi:  10.1111/j.1600-0781.2012.00690.x
    [32] Deaver D, Cauthen A, Cohen G, et al. Excimer laser in the treatment of mycosis fungoides[J]. J Am Acad Dermatol, 2014, 70:1058-1060. doi:  10.1016/j.jaad.2014.01.915
    [33] Xu CC, Zhang T, Wang T, et al. Palliative Local Radiotherapy in the Treatment of Tumor-stage Cutaneous T-cell Lymphoma/Mycosis Fungoides[J]. Chin Med Sci J, 2014, 29:33-37. doi:  10.1016/S1001-9294(14)60021-3
    [34] Bakar Ö, Şahin S, Çetinözman F, et al. Tumor-stage mycosis fungoides of the vulva successfully treated with local low-dose radiotherapy[J]. Dermatol Ther, 2015, 28:36-39. doi:  10.1111/dth.12181
    [35] Jawed SI, Myskowski PL, Horwitz S, et al. Primary cutaneous T-cell lymphoma(mycosis fungoides and Sezary syndrome) Part II. Prognosis, management, and future directions[J]. J Am Acad Dermatol, 2014, 70: 223, e1-e17. https://www.researchgate.net/publication/259805399_Primary_cutaneous_T-cell_lymphoma_mycosis_fungoides_and_Sezary_syndrome_Part_II_Prognosis_management_and_future_directions
    [36] Duvic M, Donato M, Dabaja B, et al. Total skin electron beam and non-myeloablative allogeneic hematopoietic stem-cell transplantation in advanced mycosis fungoides and Sezary syndrome[J]. J Clin Oncol, 2010, 28:2365-2372. doi:  10.1200/JCO.2009.25.8301
    [37] Wagner AE, Wada D, Bowen G, et al. Mycosis fungoides: the addition of concurrent and adjuvant interferon to total skin electron beam therapy[J]. Br J Dermatol, 2013, 169:715-718. doi:  10.1111/bjd.12386
    [38] Tandberg DJ, Craciunescu O, Kelsey CR. Radiation Therapy for Cutaneous T-Cell Lymphomas[J]. Dermatol Clin, 2015, 33:703-713. doi:  10.1016/j.det.2015.05.006
    [39] Xue J, Liu C, Liu Y. Photodynamic therapy as an alternative treatment for relapsed or refractory mycosis fungoides: a systemic review[J]. Photodiagnosis Photodyn Ther, 2017, 17:87-91. doi:  10.1016/j.pdpdt.2016.11.010
    [40] Kabata Y, Shimomura Y, Matsuo Y, et al. Photodynamic therapy with intradermal application of 5-aminolevulinic acid successfully improved tumor lesions of mycosis fungoides[J]. Int J Dermatol, 2017, 56:e81-e82. doi:  10.1111/ijd.13483
    [41] Ariel H, Cristián ND, Claudia N, et al. Topical photody-namic therapy with 5-aminolevulinate for the treatment of tumor-stage mycosis fungoides: a case report[J]. Int J Dermatol, 2013, 52:1535-1537. doi:  10.1111/j.1365-4632.2011.05427.x
    [42] Rivetti N, Cananzi R, Borroni RG, et al. Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease[J]. Dermatol Ther, 2017, 30:e12474. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=b26de49d65b748d96ce0737c61c788c8
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出版历程
  • 收稿日期:  2017-04-27
  • 刊出日期:  2020-09-18

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