邮件订阅 RSS

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肺血栓栓塞症患者生活质量评估及影响因素

孙雪峰,  李金玉,  施举红

downloadPDF
文章导航 > 协和医学杂志  > 2019 >  10(2): 133-137
孙雪峰, 李金玉, 施举红. 肺血栓栓塞症患者生活质量评估及影响因素[J]. 协和医学杂志, 2019, 10(2): 133-137. doi: 10.3969/j.issn.1674-9081.2019.02.009
引用本文: 孙雪峰, 李金玉, 施举红. 肺血栓栓塞症患者生活质量评估及影响因素[J]. 协和医学杂志, 2019, 10(2): 133-137. doi: 10.3969/j.issn.1674-9081.2019.02.009
shu
Xue-feng SUN, Jin-yu LI, Ju-hong SHI. Quality of Life in Patients with Pulmonary Thromboembolism and Its Determinants[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(2): 133-137. doi: 10.3969/j.issn.1674-9081.2019.02.009
Citation: Xue-feng SUN, Jin-yu LI, Ju-hong SHI. Quality of Life in Patients with Pulmonary Thromboembolism and Its Determinants[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(2): 133-137. doi: 10.3969/j.issn.1674-9081.2019.02.009
shu

肺血栓栓塞症患者生活质量评估及影响因素

doi: 10.3969/j.issn.1674-9081.2019.02.009
  • 1.

    中国医学科学院 北京协和医学院 北京协和医院呼吸内科，北京 100730

  • 2.

    华北理工大学附属医院重症医学科，河北唐山 063000

基金项目: 

科技部“十三五”精准医学研究重点专项 2016YF0905603

详细信息
    通讯作者:

    施举红电话：010-69155004，E-mail：shijh@pumch.cn

  • 中图分类号: R563.5

Quality of Life in Patients with Pulmonary Thromboembolism and Its Determinants

  • 1.

    Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Critical Care Medicine, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, China

More Information
    Corresponding author: SHI Ju-hong Tel：010-69155004，E-mail：shijh@pumch.cn

    摘要
  • 摘要:   目的  通过健康状况调查问卷SF-36量表评估肺血栓栓塞症(pulmonary thromboembolism，PTE)患者的生活质量并研究影响评分的相关因素。  方法  2016年5月至2017年11月在北京协和医院住院或呼吸内科门诊就诊的PTE患者受邀填写SF-36量表，并与中国普通人群比对。填写问卷的同时收集患者人口学资料(性别、年龄和肥胖状况)和临床资料[间隔时间(从诊断PTE时间至填表时间)、栓塞部位、深静脉血栓、癌症、慢性心肺疾病、诱发型PTE、一过性危险因素及永久性危险因素)，通过单因素及多因素线性回归分析明确这些变量与生活质量评分的相关性。  结果  88例符合入选排除标准的PTE患者完成SF-36量表并纳入最终分析。PTE患者SF-36量表各维度评分均低于中国普通人群：生理机能评分59.8±27.4比87.6±16.8，生理职能30.4±41.9比83.0±20.7，躯体疼痛67.4±23.6比83.3±19.7，一般健康状况43.0± 23.1比68.2±19.4，精力57.3±23.5比70.1±16.8，社会功能60.1±29.9比84.8±16.6，情感职能44.7±43.1比85.3±17.7，精神健康58.7±21.5比78.8±15.4，各维度比较均有统计学差异(P均＜0.01)。除精神健康这一变量外，PTE发生1年以上组各项生活质量评分均高于PTE发生1年内组。多因素线性回归分析显示，年龄和诱发型PTE与一般健康状况相关，间隔时间与躯体疼痛相关，一过性危险因素与生理机能、精力、社会功能及健康状况相关，而永久性危险因素则与精神健康相关。  结论  PTE患者生活质量低于普通人群，年龄、间隔时间、诱发型PTE、一过性危险因素和永久性危险因素与PTE患者生活质量相关。
    Abstract:   Objective  The aim of this study was to evaluate the quality of life in patients with pulmonary thromboembolism (PTE) by the SF-36 questionnaire and to investigate the determinants of the quality of life.  Methods  PTE patients who had discharged from Peking Union Medical College Hospital or had visited the Department of Respiratory Medicine between May 2016 and November 2017 were invited to fill the SF-36 question- naire. The  Results  were compared with the normal Chinese population. Demographic (gender, age, and obesity)and clinical data (the interval from PTE to questionnaire, locations of thrombus, deep vein thrombosis, cancer, chronic heart/pulmonary disease, provoked PTE, transient risk factor, and permanent risk factor) were collected and determinants were analyzed with the univariate and multivariate regression.  Results  Eighty-eight patients finished the SF-36 questionnaire. PTE patients had lower subscale scores of SF-36 compared with normal Chinese people: physical functioning, 59.8±27.4 vs. 87.6±16.8; role-physical, 30.4±41.9 vs. 83.0±20.7; bodily pain, 67.4±23.6 vs. 83.3±19.7; general health, 43.0±23.1 vs. 68.2±19.4; vitality, 57.3±23.5 vs. 70.1±16.8; social functioning, 60.1±29.9 vs. 84.8±16.6; role-emotional, 44.7±43.1 vs. 85.3±17.7; and mental health, 58.7±21.5 vs. 78.8±15.4 (all P < 0.01). The life quality scores of PTE that occurred more than one year before were higher than those of PTE within one year in every subscale except mental health. Multivariate regression analysis showed that: Age and provoked PTE were associated with general health; the interval from the diagnosis of PTE to questionnaire was associated with bodily pain; the transient risk factor was associated with role-physical, vitality, social functioning, health transition; and the permanent risk factor was associated with mental health.  Conclusions  The quality of life in PTE patients is generally lower than that in normal Chinese population; age, interval, provoked PTE, transient risk factor, and permanent risk factor are associated with their quality of life.
    利益冲突  无
    • HTML全文

  • 表  1  PTE患者SF-36量表各维度评分

    维度 全部PTE患者(n=88) PTE≤1年(n=73) PTE＞1年(n=15) P值
    生理机能 59.8±27.4 57.5±26.7 71.0±28.4 0.0811
    生理职能 30.4±41.9 25.7±39.5 53.3±47.1 0.0193
    躯体疼痛 67.4±23.6 65.3±24.1 77.5±18.8 0.0684
    一般健康状况 43.0±23.1 41.3±22.6 51.3±24.5 0.1275
    精力 57.3±23.5 55.8±22.4 64.3±28.3 0.2047
    社会功能 60.1±29.9 58.4±29.9 68.1±30.0 0.2559
    情感职能 44.7±43.1 41.6±42.6 60.0±44.0 0.1333
    精神健康 58.7±21.5 58.9±21.6 57.9±22.1 0.8711
    健康变化 37.8±36.2 35.3±37.0 50.0±29.9 0.1527
    PTE：肺血栓栓塞症
    下载: 导出CSV

    表  2  PTE患者SF-36量表各维度评分及与中国普通人群的比较

    维度 中国普通人群[4]
    (n=4251)    		 PTE患者
    (n=88)    		 差值 P值
    生理机能 87.6±16.8 59.8±27.4 27.8 ＜0.01
    生理职能 83.0±20.7 30.4±41.9 52.6 ＜0.01
    躯体疼痛 83.3±19.7 67.4±23.6 15.9 ＜0.01
    一般健康状况 68.2±19.4 43.0±23.1 25.2 ＜0.01
    精力 70.1±16.8 57.3±23.5 12.8 ＜0.01
    社会功能 84.8±16.6 60.1±29.9 24.7 ＜0.01
    情感职能 85.3±17.7 44.7±43.1 40.6 ＜0.01
    精神健康 78.8±15.4 58.7±21.5 20.1 ＜0.01
    健康变化 － 37.8±36.2 － －
    PTE：同表 1
    下载: 导出CSV
    • 参考文献(16)
  • [1] Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmon-ary embolism[J]. Eur Heart J, 2014, 35: 3033-3069. doi:  10.1093/eurheartj/ehu283
    [2] Reyes ME, Ye Y, Zhou Y, et al. Predictors of health-related quality of life and association with survival may identify colorectal cancer patients at high risk of poor prognosis[J]. Qual Life Res, 2017, 26: 319-330. doi:  10.1007/s11136-016-1381-8
    [3] Kaptein AA, Scharloo M, Fischer MJ, et al. 50 years of psychological research on patients with COPD—road to ruin or highway to heaven?[J]. Respir Med, 2009, 103: 3-11. doi:  10.1016/j.rmed.2008.08.019
    [4] 姜敏敏, 李鲁, 王红妹. SF-36 v2量表中国人群常模研究[J].中华预防医学会第三届学术年会暨中华预防医学会科学技术奖颁奖大会、世界公共卫生联盟第一届西太区公共卫生大会、全球华人公共卫生协会第五届年会论文集, 2009: 214. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=8051241
    [5] 申希平, 丁建生, 李娟生, 等.在SPSS中利用均数和标准差做两独立样本t检验[J].现代预防医学, 2007, 34: 4066-4067. doi:  10.3969/j.issn.1003-8507.2007.21.025
    [6] Klok FA, van Kralingen KW, van Dijk AP, et al. Quality of life in long-term survivors of acute pulmonary embolism[J]. Chest, 2010, 138: 1432-1440. doi:  10.1378/chest.09-2482
    [7] van Es J, den Exter PL, Kaptein AA, et al. Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL[J]. Thromb Res, 2013, 132: 500-505. doi:  10.1016/j.thromres.2013.06.016
    [8] Tavoly M, Utne KK, Jelsness-Jorgensen LP, et al. Health-related quality of life after pulmonary embolism: a cross-sectional study[J]. BMJ Open, 2016, 6: e013086.
    [9] Sista AK, Miller LE, Kahn SR, et al. Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: systematic review with meta-analysis[J]. Vasc Med, 2017, 22: 37-43. doi:  10.1177/1358863X16670250
    [10] Lubberts B, Paulino Pereira NR, Kabrhel C, et al. What is the effect of venous thromboembolism and related complica-tions on patient reported health-related quality of life? A meta-analysis[J]. Thromb Haemost, 2016, 116: 417-431. doi:  10.1160/TH16-02-0152
    [11] Kahn SR, Hirsch AM, Akaberi A, et al. Functional and exercise limitations after a first episode of pulmonary embolism: results of the ELOPE Prospective Cohort Study[J]. Chest, 2017, 151: 1058-1068. doi:  10.1016/j.chest.2016.11.030
    [12] Kahn SR, Akaberi A, Granton JT, et al. Quality of life, dyspnea, and functional exercise capacity following a first episode of pulmonary embolism: results of the ELOPE Cohort Study[J]. Am J Med, 2017, 130: 990.e9-e990.e21. https://www.ncbi.nlm.nih.gov/pubmed/28400247
    [13] 刘春萍, 张丽华, 李俊峡, 等.急性PTE患者生活质量及其影响因素调查[J].中国循证心血管医学杂志, 2012, 4: 228-230. doi:  10.3969/j.issn.1674-4055.2012.03.014
    [14] Kahn SR, Shbaklo H, Lamping DL, et al. Determinants of health-related quality of life during the 2 years following deep vein thrombosis[J]. J Thromb Haemost, 2008, 6: 1105-1112. doi:  10.1111/j.1538-7836.2008.03002.x
    [15] Klok FA, Cohn DM, Middeldorp S, et al. Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire[J]. J Thromb Haemost, 2010, 8: 523-532. doi:  10.1111/j.1538-7836.2009.03726.x
    [16] Cohn DM, Nelis EA, Busweiler LA, et al. Quality of life after pulmonary embolism: the development of the PEmb-QoL questionnaire[J]. J Thromb Haemost, 2009, 7: 1044-1046. doi:  10.1111/j.1538-7836.2009.03341.x
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
表(2)
计量
  • 文章访问数:  412
  • HTML全文浏览量:  34
  • PDF下载量:  121
  • 被引次数: 0
出版历程
  • 收稿日期:  2017-12-26
  • 刊出日期:  2020-09-18

目录

    /

    返回文章
    返回
    友情链接: 国家卫生健康委员会 北京协和医院 中国医学科学院 学术不端检测系统 国际知识资源总库 中国知网 术语在线 中国全科医学
    地址：北京市东城区帅府园1号 北京协和医院老楼7号楼
    3层302室 《协和医学杂志》编辑部
    电话：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    期刊网站版权所有：《协和医学杂志》编辑部
    京ICP备 11002662

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计

    x 关闭 永久关闭

    【温馨提醒】近日，《协和医学杂志》编辑部接到作者反映，有多名不法人员冒充期刊编辑发送见刊通知，鼓动作者添加微信，从而骗取版面费的行为。特提醒您，本刊与作者联系的方式均为邮件通知或电话，稿件进度通知邮箱为：mjpumch@126.com，编辑部电话为：010-69154261，请提高警惕，谨防上当受骗！如有任何疑问，请致电编辑部核实。谢谢！