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积极降压对脑小血管病防治策略的影响

刘子悦,  朱以诚

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文章导航 > 协和医学杂志  > 2019 >  10(2): 108-111
刘子悦, 朱以诚. 积极降压对脑小血管病防治策略的影响[J]. 协和医学杂志, 2019, 10(2): 108-111. doi: 10.3969/j.issn.1674-9081.2019.02.004
引用本文: 刘子悦, 朱以诚. 积极降压对脑小血管病防治策略的影响[J]. 协和医学杂志, 2019, 10(2): 108-111. doi: 10.3969/j.issn.1674-9081.2019.02.004
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Zi-yue LIU, Yi-cheng ZHU. Effect of Antihypertensive Program on the Prevention and Treatment of Cerebral Small Vessel Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(2): 108-111. doi: 10.3969/j.issn.1674-9081.2019.02.004
Citation: Zi-yue LIU, Yi-cheng ZHU. Effect of Antihypertensive Program on the Prevention and Treatment of Cerebral Small Vessel Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(2): 108-111. doi: 10.3969/j.issn.1674-9081.2019.02.004
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积极降压对脑小血管病防治策略的影响

doi: 10.3969/j.issn.1674-9081.2019.02.004

  • 中国医学科学院 北京协和医学院 北京协和医院神经科，北京 100730

基金项目: 

国家自然科学基金 81671173

科技部“十三五”国家重点研发计划 2016YFC0901004

详细信息
    通讯作者:

    电话：010-69154103，E-mail：zhuych910@163.com

  • 中图分类号: R543;R544.1

Effect of Antihypertensive Program on the Prevention and Treatment of Cerebral Small Vessel Disease

  • Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 2017年，美国心脏病学会和美国心脏协会提出将高血压诊断标准降为130/80 mm Hg(1 mm Hg=0.133 kPa)，这与其他指南有所不同。降压治疗的核心目标在于靶器官的保护，近年来降压治疗与脑小血管病预防的相关问题日益受到临床重视。目前研究结果表明, 降压治疗对腔隙性卒中患者的二级预防以及白质病变进展的预防可能有一定积极意义，但确切的降压目标值并未确定。血压与临床结局可能呈现J型关系，血压过低或过高可能均有害，而取得最大获益的降压目标有待进一步探索。
    Abstract: Recently, ACC/AHA has proposed the new diagnostic criteria of hypertension as130/80 mm Hg (1 mm Hg=0.133 kPa), which is different from other guidelines. The core goal of antihypertensive therapy is the protection of target organs. Therefore, the issues related to intensive antihypertensive therapy and the prevention of cerebral small vessel disease have attracted more attention in recent years. Current findings suggest that the antihypertensive program may have a positive effect on secondary prevention of lacunar stroke and white matter lesions. The exact target blood pressure (BP) has not been determined yet. BP and clinical outcomes may present a J-type relationship, indicating that too low or too high BP may both be harmful, and the ideal target BP is to be further explored.
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    • 参考文献(26)
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出版历程
  • 收稿日期:  2019-01-14
  • 刊出日期:  2020-09-18

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