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磁共振扩散加权成像在胰腺癌诊断中的应用

马超 陆建平

马超, 陆建平. 磁共振扩散加权成像在胰腺癌诊断中的应用[J]. 协和医学杂志, 2019, 10(1): 68-72. doi: 10.3969/j.issn.1674-9081.2019.01.010
引用本文: 马超, 陆建平. 磁共振扩散加权成像在胰腺癌诊断中的应用[J]. 协和医学杂志, 2019, 10(1): 68-72. doi: 10.3969/j.issn.1674-9081.2019.01.010
Chao MA, Jian-ping LU. Application of Diffusion Weighted Imaging in the Diagnosis of Pancreatic Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(1): 68-72. doi: 10.3969/j.issn.1674-9081.2019.01.010
Citation: Chao MA, Jian-ping LU. Application of Diffusion Weighted Imaging in the Diagnosis of Pancreatic Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(1): 68-72. doi: 10.3969/j.issn.1674-9081.2019.01.010

磁共振扩散加权成像在胰腺癌诊断中的应用

doi: 10.3969/j.issn.1674-9081.2019.01.010
基金项目: 

国家自然科学基金资助项目 81601468

第二军医大学精准医学转化应用研究专项资助项目 2017JZ42

详细信息
    通讯作者:

    陆建平  电话:021-31162146,E-mail:cjr.lujianping@vip.163.com

  • 中图分类号: R445.1

Application of Diffusion Weighted Imaging in the Diagnosis of Pancreatic Cancer

More Information
  • 摘要: 胰腺癌是最主要的胰腺肿瘤, 其5年生存率不足5%, 早期发现、有效评估及采取恰当的治疗十分关键。自1984年磁共振扩散加权成像(diffusion weighted imaging, DWI)首次被报道以来, 其临床研究和应用价值日益凸显。DWI作为磁共振成像检查序列之一, 为胰腺癌的诊断、鉴别诊断及治疗效果评价等提供重要信息。本文对DWI技术及其在胰腺癌中的应用进行综述。
    利益冲突  无
  • [1] Hidalgo M, Cascinu S, Kleeff J, et al.Addressing the challenges of pancreatic cancer:future directions for improving outcomes[J].Pancreatology, 2015, 15:8-18.
    [2] 李慧超, 王宁, 郑荣寿, 等.中国2010年胰腺癌发病和死亡分析[J].中国肿瘤, 2015, 24:163-169.
    [3] De Robertis R, Tinazzi MP, Demozzi E, et al.Diffusion-weighted imaging of pancreatic cancer[J].World J Radiol, 2015, 7:319-328.
    [4] Stejskal EO, Tanner JE.Spin diffusion measurements:spin echoes in the presence of time-dependent field gradient[J].J Chem Phys, 1965, 42:288-292.
    [5] Iima M, Le Bihan D.Clinical intravoxel incoherent motion and diffusion MR imaging:past, present, and future[J].Radiology, 2016, 278:13-32.
    [6] Bennett KM, Schmainda KM, Bennett RT, et al.Characterization of continuously distributed cortical water diffusion rates with a stretched-exponential model[J].Magn Reson Med, 2003, 50:727-734.
    [7] Jensen JH, Helpern JA, Ramani A, et al.Diffusional kurtosis imaging:the quantification of non-gaussian water diffusion by means of magnetic resonance imaging[J].Magn Reson Med, 2005, 53:1432-1440.
    [8] Kwee TC, Takahara T, Koh DM, et al.Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free-breathing diffusion-weighted MR imaging of the liver[J].J Magn Reson Imaging, 2008, 28:1141-1148.
    [9] Taouli B, Beer AJ, Chenevert T, et al.Diffusion-weighted imaging outside the brain:consensus statement from an ISMRM-sponsored workshop[J].J Magn Reson Imaging, 2016, 44:521-540.
    [10] Ma C, Li YJ, Pan CS, et al.High resolution diffusion weighted magnetic resonance imaging of the pancreas using reduced field of view single-shot echo-planar imaging at 3T[J].Magn Reson Imaging, 2014, 32:125-131.
    [11] Riffel P, Michaely HJ, Morelli JN, et al.Zoomed EPI-DWI of the pancreas using two-dimensional spatially-selective radiofrequency excitation pulses[J].PLoS One, 2014, 9:e89468.
    [12] Kim H, Lee JM, Yoon JH, et al.Reduced field-of-view diffusion-weighted magnetic resonance imaging of the pancreas:comparison with conventional single-shot echo-planar imaging[J].Korean J Radiol, 2015, 16:1216-1225.
    [13] 王萍, 翟昭华, 李培岭, 等.DWI在恶性胶质瘤和单发脑转移瘤鉴别中的应用研究[J].国际医学放射学杂志, 2013, 36:431-434.
    [14] Fukukura Y, Shindo T, Hakamada H, et al.Diffusion-weighted MR imaging of the pancreas:optimizing b-value for visualization of pancreatic adenocarcinoma[J].Eur Radiol, 2016, 26:3419-3427.
    [15] Le Bihan D, Johansen-Berg H.Diffusion MRI at 25:exploring brain tissue structure and function[J].Neuroimage, 2012, 61:324-341.
    [16] Ma C, Liu L, Li J, et al.Apparent diffusion coefficient (ADC) measurements in pancreatic adenocarcinoma:a preliminary study of the effect of region of interest on ADC values and interobserver variability[J].J Magn Reson Imaging, 2016, 43:407-413.
    [17] Corona-Villalobos CP, Pan L, Halappa VG, et al.Agreement and reproducibility of apparent diffusion coefficient measurements of dual-b-value and multi-b-value diffusion-weighted magnetic resonance imaging at 1.5 Tesla in phantom and in soft tissues of the abdomen[J].J Comput Assist Tomogr, 2013, 37:46-51.
    [18] Liu L, Ma C, Li J, et al.Comparison of the diagnostic performances of three techniques of ROI placement for ADC measurements in pancreatic adenocarcinoma[J].Acad Radiol, 2015, 22:1385-1389.
    [19] Ma C, Li J, Boukar MB, et al.Optimized ROI size on ADC measurements of normal pancreas, pancreatic cancer and mass-forming chronic pancreatitis[J].Oncotarget, 2017, 8:99085-99092.
    [20] Ma C, Guo X, Liu L, et al.Effect of region of interest size on ADC measurements in pancreatic adenocarcinoma[J].Cancer Imaging, 2017, 17:13.
    [21] Just N.Improving tumour heterogeneity MRI assessment with histograms[J].Br J Cancer, 2014, 111:2205-2213.
    [22] Ma X, Zhao X, Ouyang H, et al.Quantified ADC histogram analysis:a new method for differentiating mass-forming focal pancreatitis from pancreatic cancer[J].Acta Radiol, 2014, 55:785-792.
    [23] Pereira JA, Rosado E, Bali M, et al.Pancreatic neuroendocrine tumors:correlation between histogram analysis of apparent diffusion coefficient maps and tumor grade[J].Abdom Imaging, 2015, 40:3122-3128.
    [24] Fukukura Y, Takumi K, Kamimura K, et al.Pancreatic adenocarcinoma:variability of diffusion-weighted MR imaging findings[J].Radiology, 2012, 263:732-740.
    [25] Legrand L, Duchatelle V, Molinié V, et al.Pancreatic adenocarcinoma:MRI conspicuity and pathologic correlations[J].Abdom Imaging, 2015, 40:85-94.
    [26] Wang Y, Chen ZE, Nikolaidis P, et al.Diffusion-weighted magnetic resonance imaging of pancreatic adenocarcinomas:association with histopathology and tumor grade[J].J Magn Reson Imaging, 2011, 33:136-142.
    [27] Lee SS, Byun JH, Park BJ, et al.Quantitative analysis of diffusion-weighted magnetic resonance imaging of the pancreas:usefulness in characterizing solid pancreatic masses[J].J Magn Reson Imaging, 2008, 28:928-936.
    [28] Rosenkrantz AB, Matza BW, Sabach A, et al.Pancreatic cancer:lack of association between apparent diffusion coefficient values and adverse pathological features[J].Clin Radiol 2013, 68:e191-e197.
    [29] Kamisawa T, Takuma K, Anjiki H, et al.Differentiation of autoimmune pancreatitis from pancreatic cancer by diffusion-weighted MRI[J].Am J Gastroenterol, 2010, 105:1870-1875.
    [30] Muraoka N, Uematsu H, Kimura H, et al.Apparent diffusion coefficient in pancreatic cancer:characterization and histopathological correlations[J].J Magn Reson Imaging, 2008, 27:1302-1308.
    [31] Fattahi R, Balci NC, Perman WH, et al.Pancreatic diffusion-weighted imaging (DWI):comparison between mass-forming focal pancreatitis (FP), pancreatic cancer (PC), and normal pancreas[J].J Magn Reson Imaging, 2009, 29:350-356.
    [32] Park MJ, Kim YK, Choi SY, et al.Preoperative detection of small pancreatic carcinoma:value of adding diffusion-weighted imaging to conventional MR imaging for improving confidence level[J].Radiology, 2014, 273:433-443.
    [33] Niekel MC, Bipat S, Stoker J.Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT:a meta-analysis of prospective studies including patients who have not previously undergone treatment[J].Radiology, 2010, 257:674-684.
    [34] Barral M, Taouli B, Guiu B, et al.Diffusion-weighted MR imaging of the pancreas:current status and recommendations[J].Radiology, 2015, 274:45-63.
    [35] Barral M, Sebbag-Sfez D, Hoeffel C, et al.Characterization of focal pancreatic lesions using normalized apparent diffusion coefficient at 1.5-Tesla:preliminary experience[J].Diagn Interv Imaging, 2013, 94:619-627.
    [36] Hayano K, Miura F, Amano H, et al.Correlation of apparent diffusion coefficient measured by diffusion-weighted MRI and clinicopathologic features in pancreatic cancer patients[J].J Hepatobiliary Pancreat Sci, 2013, 20:243-248
    [37] Ma C, Li Y, Wang L, et al.Intravoxel incoherent motion DWI of the pancreatic adenocarcinomas:monoexponential and biexponential apparent diffusion parameters and histopathological correlations[J].Cancer Imaging, 2017, 17:12.
    [38] Klauss M, Lemke A, Grunberg K, et al.Intravoxel incohe-rent motion MRI for the differentiation between mass forming chronic pancreatitis and pancreatic carcinoma[J].Invest Radiol, 2011, 46:57-63.
    [39] Concia M, Sprinkart AM, Penner AH, et al.Diffusion-weighted magnetic resonance imaging of the pancreas:diagnostic benefit from an intravoxel incoherent motion model-based 3b-value analysis[J].Invest Radiol, 2014, 49:93-100.
    [40] Kang KM, Lee JM, Yoon JH, et al.Intravoxel incoherent motion diffusion-weighted MR imaging for characterization of focal pancreatic lesions[J].Radiology, 2014, 270:444-453.
    [41] Klauss M, Gaida MM, Lemke A, et al.Fibrosis and pancreatic lesions:counterintuitive behavior of the diffusion imaging-derived structural diffusion coefficient D[J].Invest Radiol, 2013, 48:129-133.
    [42] Niwa T, Ueno M, Ohkawa S, et al.Advanced pancreatic cancer:the use of the apparent diffusion coefficient to predict response to chemotherapy[J].Br J Radiol, 2009, 82:28-34.
    [43] Cuneo KC, Chenevert TL, Ben-Josef E, et al.A pilot study of diffusion-weighted MRI in patients undergoing neoadjuvant chemoradiation for pancreatic cancer[J].Transl Oncol, 2014, 7:644-649.
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出版历程
  • 收稿日期:  2017-09-27
  • 刊出日期:  2020-02-01

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