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原发性心肌病诊断新路径:从高分辨影像到分子精准医学

吴炜,  王怡宁,  代静文,  金征宇,  张抒扬

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文章导航 > 协和医学杂志  > 2019 >  10(1): 6-10
吴炜, 王怡宁, 代静文, 金征宇, 张抒扬. 原发性心肌病诊断新路径:从高分辨影像到分子精准医学[J]. 协和医学杂志, 2019, 10(1): 6-10. doi: 10.3969/j.issn.1674-9081.2019.01.002
引用本文: 吴炜, 王怡宁, 代静文, 金征宇, 张抒扬. 原发性心肌病诊断新路径:从高分辨影像到分子精准医学[J]. 协和医学杂志, 2019, 10(1): 6-10. doi: 10.3969/j.issn.1674-9081.2019.01.002
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Wei WU, Yi-ning WANG, Jing-wen DAI, Zheng-yu JIN, Shu-yang ZHANG. New Clinical Diagnostic Pathway of Primary Cardiomyopathy: from High-resolution Imaging to Molecular Precision Medicine[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(1): 6-10. doi: 10.3969/j.issn.1674-9081.2019.01.002
Citation: Wei WU, Yi-ning WANG, Jing-wen DAI, Zheng-yu JIN, Shu-yang ZHANG. New Clinical Diagnostic Pathway of Primary Cardiomyopathy: from High-resolution Imaging to Molecular Precision Medicine[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(1): 6-10. doi: 10.3969/j.issn.1674-9081.2019.01.002
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原发性心肌病诊断新路径:从高分辨影像到分子精准医学

doi: 10.3969/j.issn.1674-9081.2019.01.002
  • 1.

    中国医学科学院 北京协和医学院 北京协和医院 心内科，北京 100730

  • 2.

    中国医学科学院 北京协和医学院 北京协和医院 放射科，北京 100730

  • 3.

    中国医学科学院 北京协和医学院 北京协和医院 罕见病研究中心，北京 100730

基金项目: 

国家重点研发计划资助项目 2016YFC0901500

国家重点研发计划资助项目 2016YFC0905102

中国医学科学院医学与健康科技创新工程项目 2017-I2M-2-002

详细信息
    通讯作者:

    张抒扬  电话:010-69155068,E-mial:zhangshuyang2018@126.com

  • 中图分类号: R445;R542.2

New Clinical Diagnostic Pathway of Primary Cardiomyopathy: from High-resolution Imaging to Molecular Precision Medicine

  • 1.

    Department of Cardiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Center for Rare Diseases Research Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 原发性心肌病的既往定义是一大类未明原因造成的心肌直接异常, 而非继发于缺血、高血压、糖尿病、甲状腺功能亢进等因素。其临床诊断路径局限于描述心肌损害以后造成的心脏结构与功能异常, 如扩张、肥厚、限制以及收缩性或舒张性心力衰竭等。随着诊断技术的进步, 尤其是高分辨影像技术和分子精准医学的突破性进展, 先前的原发性心肌病定义以及诊断路径已不能满足临床需求。新时代下, 具有条件的大型医学中心应采用新的临床诊断路径, 其内容涵盖高分辨影像与遗传学分析, 可为原发性心肌病提供更为充分的影像与精准医学信息, 并为后续的影像组学分析、基因治疗、靶向药物研发、遗传学咨询等创造条件。
    Abstract: Primary cardiomyopathies were previously defined as primary myocardial disorders of unknown causes, in which the secondary effect of ischemia, hypertension, diabetes, and hyperthyroidism, etc. was excluded. The clinical diagnostic pathway was limited to describing the structural and functional abnormalities, such as dilatation, hypertrophy, restrictive cardiomyopathies, and systolic or diastolic heart failure. With the progression of diagnostic techniques, especially of high-resolution imaging and molecular precision medicine, the previous definition and pathway cannot satisfy clinical demands. Accordingly, large medical centers with sufficient equipment should adopt a new clinical diagnostic pathway including high-resolution imaging and genetic analysis in the new era, which would supply more precise information of cardiac images and particular genetic abnormalities. This new pathway will greatly help the radiomics analysis, gene therapy, the development of targeted drugs, and genetic counseling for patients with cardiomyopathies.
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    • 参考文献(23)
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出版历程
  • 收稿日期:  2018-10-04
  • 刊出日期:  2020-02-01

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