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表 1 29例SAPHO综合征患者心理疾病状况
心理疾病 人数(n) 比例(%) 抑郁障碍 16 55.2 复发性抑郁障碍 3 10.3 现患抑郁障碍 9 31.0 既往抑郁障碍 10 34.5 伴忧抑郁特征 3 10.3 伴自杀观念 2 6.9 焦虑障碍 5 17.2 现患惊恐障碍 1 3.4 广场恐惧症 2 6.9 社交恐惧症 1 3.4 强迫性障碍 1 3.4 广泛性焦虑障碍 2 6.9 双相情感障碍 3 10.3 既往轻躁狂 3 10.3 现患躁狂/轻躁狂 0 0 既往躁狂 0 0 任何一种精神障碍 18 62.1 ≥2种精神障碍 8 27.6 
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表 2 29例SAPHO综合征患者人口学资料及临床特点
项目 MDD组(n)=16 非MDD组(n)=13 p值 性别[n(%)] 0.006# 男 5(31.3) 9(69.2) 女 11(68.7) 4(30.8) 年龄(x±s, 岁) 49±9 40±14 0.045# 婚姻状况[n(%)] 0.344# 已婚 12(75.0) 10(76.9) 未婚 0(0) 2(15.4) 丧偶或离异 1(6.3) 0(0) 未回答 3(18.7) 1(7.7) 居住情况[n(%)] 0.483# 独居 2(12.5) 1(7.7) 与父母同住 2(12.5) 4(30.8) 与配偶同住 8(50.0) 5(38.5) 未回答 4(25.0) 3(23.1) 病程[M(Q), 月] 17(1~156) 11(2~85) 0.577† 起病年龄(x±s, 岁) 45±9 34±13 0.012* 首发病状（皮疹与关节症状出现的先后顺序）[n(%)] 0.027# 皮疹在前 5(31.3) 9(69.2) 同时出现 7(43.7) 1(7.7) 皮疹在后 4(25.0) 1(7.7) 无皮疹 0(0) 1(7.7) 未回答 - 1(7.7) #Fisher精确概率法分析；*独立样本t检验; 非参数检验; MDD:垂性抑郁障碍
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[1] Chamot AM, Benhamou CL, Kahn MF, et al. Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases[J]. Rev Rhum Mal Osteoartic, 1987, 54:187-196. http://cn.bing.com/academic/profile?id=56a917b628a813067d28fc61c3d55e7a&encoded=0&v=paper_preview&mkt=zh-cn [2] Hayem G. Valuable lessons from SAPHO syndrome[J]. Joint Bone Spine, 2007, 74:123-126. doi: 10.1016/j.jbspin.2006.06.006 [3] Orion E, Brenner S. Stress-induced SAPHO syndrome[J]. J Eur Acad Dermatol Venereol, 1999, 12:43-46. doi: 10.1111/j.1468-3083.1999.tb00807.x [4] Wohl Y, Bergman R, Sprecher E, et al. Stress in a case of SAPHO syndrome[J]. Cutis, 2003, 71:63-67. http://www.ncbi.nlm.nih.gov/pubmed/12553632 [5] Govoni M, Colina M, Massara A, et al. SAPHO syndrome and infections[J]. Autoimmun Rev, 2009, 8:256-259. doi: 10.1016/j.autrev.2008.07.030 [6] Lakshmi DB, Narasimha R. SAPHO syndrome with acne fulmonans and severe polyosteitis involving axial skeleton[J]. Indian Dermatol Online J, 2016, 7:414-417. doi: 10.4103/2229-5178.190495 [7] Lapteva L, Nowak M, Yarboro CH, et al. Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus[J]. Arthritis Rheum, 2006, 54:2505. doi: 10.1002/art.22031 [8] Chen L, Yuzhi Z, Nan W, et al. Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome:a single centre study of a cohort of 164 patients[J]. Rheumatology, 2016, 55:1023-1030. doi: 10.1093/rheumatology/kew015 [9] Govoni M, Colina M, Massara A, et al. SAPHO syndrome and infections[J]. Autoimmun Rev, 2009, 8:256-259. doi: 10.1016/j.autrev.2008.07.030 [10] Duan N, Chen X, Liu YK, et al. Multimodal imaging findings of SAPHO syndrome with no skin lesions:a report of three cases and review of the literature[J]. Exp Ther Med, 2016, 12:2665-2670. doi: 10.3892/etm.2016.3689 -
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