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感染性疾病病原学诊断新技术与临床应用策略

张坚磊,  马小军

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文章导航 > 协和医学杂志  > 2018 >  9(5): 399-403
张坚磊, 马小军. 感染性疾病病原学诊断新技术与临床应用策略[J]. 协和医学杂志, 2018, 9(5): 399-403. doi: 10.3969/j.issn.1674-9081.2018.05.004
引用本文: 张坚磊, 马小军. 感染性疾病病原学诊断新技术与临床应用策略[J]. 协和医学杂志, 2018, 9(5): 399-403. doi: 10.3969/j.issn.1674-9081.2018.05.004
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Jian-lei ZHANG, Xiao-jun MA. New Technology of Etiologic Diagnosis in Infectious Diseases and Its Clinical Application Strategy[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(5): 399-403. doi: 10.3969/j.issn.1674-9081.2018.05.004
Citation: Jian-lei ZHANG, Xiao-jun MA. New Technology of Etiologic Diagnosis in Infectious Diseases and Its Clinical Application Strategy[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(5): 399-403. doi: 10.3969/j.issn.1674-9081.2018.05.004
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感染性疾病病原学诊断新技术与临床应用策略

doi: 10.3969/j.issn.1674-9081.2018.05.004
  • 1.

    天津市第一中心医院检验科，天津 300192

  • 2.

    中国医学科学院 北京协和医学院 北京协和医院感染内科，北京 100730

基金项目: 

国家临床重点专科建设项目 2013-544

详细信息
    通讯作者:

    马小军    电话：010-69155081,E-mail:drmaxiaojun@sina.com

  • 中图分类号: R446.5;R51;R-1

New Technology of Etiologic Diagnosis in Infectious Diseases and Its Clinical Application Strategy

  • 1.

    Department of Clinical Laboratory, Tianjin First Center Hospital, Tianjin 300192, China

  • 2.

    Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 感染性疾病仍是威胁人类健康的主要疾病，传统诊断技术已无法满足临床需求，病原学诊断技术的发展对感染性疾病的诊断治疗至关重要。近年来，非培养的新型诊断技术正在迅速发展，特别是基于侧流免疫层析法和实时聚合酶链式反应为基础的即时检验，以及基于蛋白质组学质谱和高通量测序技术不断应用于临床，使感染性疾病的临床诊断向着更便捷、快速、准确的方向发展。但仍需正确对待新型诊断技术在临床应用中的问题，从循证医学角度评估诊断试验，关注应用人群，以最佳证据应用于合适人群以达到最佳效果，让病原学诊断新技术的应用真正解决临床诊断问题，最终为临床感染性疾病诊疗的科学决策提供依据。
    Abstract: Infectious diseases are still the main diseases that threaten human health. Traditional diagnostic technology has been unable to meet the clinical needs. The development of pathogenic diagnosis technology is of vital importance to the diagnosis and treatment of infectious diseases. In recent years, non-cultured new diagnostic technologies have been rapidly developing, especially the real-time detection based on lateral flow immunoassay and real-time polymerase chain reaction. The continuous application of proteomics mass-spectrometry and high-throughput sequencing technology in clinical practice makes the clinical diagnosis of infectious diseases more convenient, faster and more accurate. However, it is necessary to correctly handle the problems in the clinical application of new diagnostic technology. Diagnostic tests should be assessed from the angle of evidence-based medicine and the applied crowds to gather the best evidence, so that they can be applied to the appropriate people and achieve the best effect, making the application of new technology in etiologic diagnosis really solve the problem of clinical diagnosis and eventually provide the basis for scientific decision-making about the clinical diagnosis and treatment of infectious diseases.
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    • 参考文献(21)
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出版历程
  • 收稿日期:  2018-06-11
  • 刊出日期:  2018-09-30

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