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结缔组织病相关间质性肺疾病:必须重视的疾病

陈志磊,  张奉春

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文章导航 > 协和医学杂志  > 2018 >  9(3): 193-196
陈志磊, 张奉春. 结缔组织病相关间质性肺疾病:必须重视的疾病[J]. 协和医学杂志, 2018, 9(3): 193-196. doi: 10.3969/j.issn.1674-9081.2018.03.001
引用本文: 陈志磊, 张奉春. 结缔组织病相关间质性肺疾病:必须重视的疾病[J]. 协和医学杂志, 2018, 9(3): 193-196. doi: 10.3969/j.issn.1674-9081.2018.03.001
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Zhi-lei CHEN, Feng-chun ZHANG. Connective Tissue Disease-Associated Interstitial Lung Disease: a Disease Worthy of Great Attention[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(3): 193-196. doi: 10.3969/j.issn.1674-9081.2018.03.001
Citation: Zhi-lei CHEN, Feng-chun ZHANG. Connective Tissue Disease-Associated Interstitial Lung Disease: a Disease Worthy of Great Attention[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(3): 193-196. doi: 10.3969/j.issn.1674-9081.2018.03.001
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结缔组织病相关间质性肺疾病:必须重视的疾病

doi: 10.3969/j.issn.1674-9081.2018.03.001
  • 1.

    中国医学科学院 北京协和医学院 北京协和医院 风湿免疫科, 北京 100730

  • 2.

    中国医学科学院 北京协和医学院 北京协和医院 教育部重点实验室, 北京 100730

详细信息
    通讯作者:

    张奉春 电话:010-69155007, E-mail:zhangfccra@aliyun.com

  • 中图分类号: R563.1+3;R593.2

Connective Tissue Disease-Associated Interstitial Lung Disease: a Disease Worthy of Great Attention

  • 1.

    Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 结缔组织病(connective tissue disease, CTD)是以自身免疫及其介导的器官系统损伤为特征的一组全身性疾病。肺部并发症是CTD的重要关节外表现, 也是CTD患者死亡的主要原因。临床管理CTD相关间质性肺疾病(CTD-associated interstitial lung disease, CTD-ILD)的关键是确定ILD类型、疾病所处阶段、应给予何种治疗。目前CTD-ILD仍采用特发性间质性肺炎分类, 其诊断治疗尚无统一的临床指导策略。越来越多的研究发现, 自身抗体与CTD-ILD相关, 对临床诊治具有一定指导意义, 临床实践中应更多关注那些肺部表现不明显的CTD患者, 以尽早识别CTD-ILD, 给予适当治疗, 延缓疾病进展。
    Abstract: Connective tissue disease (CTD) is a group of systemic disorder characterized by autoimmunity and autoimmune-mediated organ and system damage. The pulmonary complication is an important extra-articular feature of CTD and a major cause of mortality. The key point in the management of CTD-associated interstitial lung disease (CTD-ILD) should focus on the type of ILD, the stage of the disease, and what proper measures should be taken. CTD-ILD is still using the classification of idiopathic interstitial pneumonia. However, there is no authoritative clinical guidance for the diagnosis and treatment of CTD-ILD. More and more studies show that some auto-antibodies are strongly associated with CTD-ILD, which may guide clinical practice. In clinical practice, physicians should particularly pay more attention to CTD patients with insignificant pulmonary manifestations, so as to identify CTD-ILD in the early stage and intervene at the right time to delay the progression.
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    • 参考文献(21)
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  • 收稿日期:  2018-05-03
  • 刊出日期:  2018-05-30

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