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印记基因与小于胎龄儿研究进展

潘周娴 陈适 朱惠娟 龚凤英 潘慧

潘周娴, 陈适, 朱惠娟, 龚凤英, 潘慧. 印记基因与小于胎龄儿研究进展[J]. 协和医学杂志, 2020, 11(2): 186-190. doi: 10.3969/j.issn.1674-9081.20170084
引用本文: 潘周娴, 陈适, 朱惠娟, 龚凤英, 潘慧. 印记基因与小于胎龄儿研究进展[J]. 协和医学杂志, 2020, 11(2): 186-190. doi: 10.3969/j.issn.1674-9081.20170084
Zhou-xian PAN, Shi CHEN, Hui-juan ZHU, Feng-ying GONG, Hui PAN. Imprinted Genes and Being Small for Gestational Age[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 186-190. doi: 10.3969/j.issn.1674-9081.20170084
Citation: Zhou-xian PAN, Shi CHEN, Hui-juan ZHU, Feng-ying GONG, Hui PAN. Imprinted Genes and Being Small for Gestational Age[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 186-190. doi: 10.3969/j.issn.1674-9081.20170084

印记基因与小于胎龄儿研究进展

doi: 10.3969/j.issn.1674-9081.20170084
基金项目: 

北京市卫生科技成果与适宜技术推广项目 2018-TG-35

详细信息
    通讯作者:

    潘慧 电话:010-69155684, E-mail:panhui20111111@163.com

  • 中图分类号: R394.3;R72;R58

Imprinted Genes and Being Small for Gestational Age

More Information
  • 摘要: 基因组印记是令一对等位基因仅表达父源或母源基因的一种表观遗传性修饰, 多在胎盘中存在, 对胎盘和胚胎发育至关重要。在对小于胎龄儿发病机制的研究中, 印记基因是不可缺少的一部分。但相关研究争议很大, 尚未得出统一的结论。本文就近些年印记基因与小于胎龄儿的研究予以综述。
    利益冲突  无
  • 1  可能与SGA/IUGR相关的印记基因

    基因 部位 研究样本(例) SGA/IUGR
    甲基化程度 基因表达量
    IGF2(父) 脐带血 SGA:69, AGA:471[11] -
    SGA:33, AGA:475[18] -
    胎盘 IUGR:14, 非IUGR:15[21] -
    SGA:24, AGA:20[14] -
    SGA:130, AGA:387, LGA:160[4] 无关 无关
    SGA:33, AGA:51, LGA:22[26] - 无关
    早孕期绒毛膜 SGA:50, AGA:145, LGA:65[22] -
    外周血 SGA:80, AGA:73[12] -
    H19(母) 脐带血 SGA:69, AGA:471[11] 无关 -
    SGA:39, AGA:49[7] -
    胎盘 SGA:130, AGA:387, LGA:160[4] 无关 无关
    SGA:33, AGA:51, LGA:22[26] - 无关
    SGA:24, AGA:20[14] - 无关
    MEST(父) 胎盘 SGA:130, AGA:387, LGA:160[4]
    IUGR:14, 非IUGR:15[21] 无关
    SGA:33, AGA:51, LGA:22[26] - 无关
    脐带血 SGA:39, AGA:49[7] 无关 -
    PHLDA2(母) 胎盘 SGA:130, AGA:387, LGA:160[4] 无关 无关
    IUGR:14, 非IUGR:15[21] 无关
    SGA:33, AGA:51, LGA:22[26] - 无关
    SGA:36, AGA:41[24] - 无关
    早孕期绒毛膜 SGA:50, AGA:145, LGA:65[22] - 无关
    MEG3(母) 胎盘 SGA:130, AGA:387, LGA:160[4] 无关 无关,但表达增加与LGA相关
    IUGR:14, 非IUGR:15[21] -
    SGA:33, AGA:51, LGA:22[26] - 无关
    DLK1(父) 胎盘 SGA:130, AGA:387, LGA:160[4] 无关 无关,但表达增加与LGA相关
    SGA:33, AGA:51, LGA:22[26] - 无关
    NNAT(父) 胎盘 SGA:130, AGA:387, LGA:160[4] 无关
    SGA:33, AGA:51, LGA:22[26] -无关
    GNAS 胎盘 IUGR:14, 非IUGR:15[21] -
    SGA:130, AGA:387, LGA:160[4] 无关 无关
    PLAGL1(父) 胎盘 IUGR:14, 非IUGR:15[21] -
    SGA:33, AGA:51, LGA:22[26] -无关
    SGA:130, AGA:387, LGA:160[4] 无关 无关
    CDKN1C(母) 胎盘 IUGR:14, 非IUGR:15[21] -
    SGA:130, AGA:387, LGA:160[4] 无关 无关
    SLC22A18(母) 胎盘 SGA:33, AGA:51, LGA:22[26] -
    SGA:130, AGA:387, LGA:160[4] 无关 无关
    ZNF331(父) 胎盘 SGA:33, AGA:51, LGA:22[26] -
    SGA:130, AGA:387, LGA:160[4] 无关 无关
    SGA:小于胎龄儿;IUGR:宫内发育受限;AGA:适于胎龄儿;LGA:大于胎龄儿;↑:增加;↓:降低;-:未测
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出版历程
  • 收稿日期:  2017-05-31
  • 刊出日期:  2020-03-30

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