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摘要: 输血相关性急性肺损伤(transfusion-related acute lung injury, TRALI)是输血导致死亡的首要原因, 但临床缺乏有效的防治手段, 了解其病理生理机制有助于更有效地预防TRALI。根据介导因子不同, 可将其分为抗体介导(免疫性)和非抗体介导(非免疫性)TRALI; 前者主要由被动输注内源性抗体导致, 后者主要由血制品中的可溶性分子和某些细胞成分介导。本文旨在对非抗体介导TRALI的发病机制及研究现状进行综述, 为临床工作提供理论指导。
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关键词:
- 输血相关性急性肺损伤 /
- 生物反应调节因子 /
- 输血
Abstract: Transfusion related acute lung injury (TRALI) is a leading cause of transfusion related death. It is helpful to prevent and cure TRALI by understanding the potential mechanism of TRALI. Based on causative factors, it is divided into antibody mediated TRALI and non-antibody mediated TRALI; the former is caused by the passively infused endogenous antibodies, and the latter is mediated by the soluble molecules andcellular components from blood products.This review focuses on mechanisms of non-antibody mediated TRALI which include biological response modifiers accumulating during storage of red blood cells (RBCs) and platelets (PLTs), as well as changes in morphology and function of aged PLTs and RBCs, and the current research progress, so as to provide theoretical direction for clinical practice. -
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