-
摘要: 结节性硬化症(tuberous sclerosis complex, TSC)是一种累及多个器官和系统的常染色体显性遗传疾病, 几乎可累及人体所有器官及系统。TSC常表现为皮肤病性损害及内脏良性肿瘤, 亦有少部分恶性程度较高的肿瘤, 例如室管膜下巨细胞星形细胞瘤(subependymal giant cell astrocytoma, SEGA)、肾细胞癌等。越来越多的证据表明, 微小RNA与TSC相关病变的发生有密切关系, 起着癌基因或抑癌基因的作用。本文针对微小RNA在TSC相关病变如肺及神经系统疾病中的研究进展作一综述。Abstract: Tuberous sclerosis complex(TSC) is an autosomal dominant genetic disease involving multiple organs and systems. It can involve all organs and systems in the body. Nodular sclerosis is often manifested as skin lesions and visceral benign tumors, as well as a small number of highly malignant tumors, such as subependymal giant cell astrocytoma(SEGA), renal cell carcinoma and so on. There is growing evidence that microRNAs(miRNAs) are closely related to TSC related diseases and act as oncogenes or tumor suppressor genes. This paper reviews the progress of study on miRNA in several diseases related to tuberous sclerosis complex.
-
Key words:
- tuberous sclerosis complex /
- microRNA /
- molecular mechanism
-
[1] Wu F, Zikusoka M, Trindade A, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha[J]. Gastroenterology, 2008, 135:1624-1635. doi: 10.1053/j.gastro.2008.07.068 [2] Sayed D, Hong C, Chen IY, et al. MicroRNAs play an essential role in the development of cardiac hypertrophy[J]. Circ Res, 2007, 100:416-424. doi: 10.1161/01.RES.0000257913.42552.23 [3] Pandit KV, Corcoran D, Yousef H, et al. Inhibition and role of let-7d in idiopathic pulmonary fibrosis[J]. Am J Respir Crit Care Med, 2010, 182:220-229. doi: 10.1164/rccm.200911-1698OC [4] Milosevic J, Pandit K, Magister M, et al. Profibrotic role of miR-154 in pulmonary fibrosis[J]. Am J Respir Cell Mol Biol, 2012, 47:879-887. doi: 10.1165/rcmb.2011-0377OC [5] Bartels CL, Tsongalis GJ. MicroRNAs:novel biomarkers for human cancer[J]. Clin Chem, 2009, 55:623-631. doi: 10.1373/clinchem.2008.112805 [6] Finlay G. The LAM cell:what is it, where does it come from, and why does it grow?[J]. Am J Physiol Lung Cell Mol Physiol, 2004, 286:L690-L693. doi: 10.1152/ajplung.00311.2003 [7] Bissler JJ, McCormack FX, Young LR, et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis[J]. N Engl J Med, 2008, 358:140-151. doi: 10.1056/NEJMoa063564 [8] McCormack FX, Inoue Y, Moss J, et al. Efficacy and safety of sirolimus in lymphangioleiomyomatosis[J]. N Engl J Med, 2011, 364:1595-1606. doi: 10.1056/NEJMoa1100391 [9] Trindade AJ, Medvetz DA, Neuman NA, et al. MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis(TSC) and lymphangioleiomyomatosis(LAM)[J]. PLoS One, 2013, 8:e60014. doi: 10.1371/journal.pone.0060014 [10] Medina PP, Nolde M, Slack FJ. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma[J]. Nature, 2010, 467:86-90. doi: 10.1038/nature09284 [11] Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21(miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer[J]. Oncogene, 2008, 27:2128-2136. doi: 10.1038/sj.onc.1210856 [12] Ma X, Kumar M, Choudhury SN, et al. Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis[J]. Proc Natl Acad Sci USA, 2011, 108:10144-10149. doi: 10.1073/pnas.1103735108 [13] Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer[J]. Gastroenterology, 2007, 133:647-658. doi: 10.1053/j.gastro.2007.05.022 [14] Scott CL, Walker DJ, Cwiklinski E, et al. Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock[J]. Am J Physiol Lung Cell Mol Physiol, 2010, 299:L455-L471. doi: 10.1152/ajplung.00348.2009 [15] Wang M, Li W, Chang GQ, et al. MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities[J]. Arterioscler Thromb Vasc Biol, 2011, 31:2044-2053. doi: 10.1161/ATVBAHA.111.229559 [16] Chan MC, Hilyard AC, Wu C, et al. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression[J]. EMBO J, 2010, 29:559-573. doi: 10.1038/emboj.2009.370 [17] Goncharova EA, Goncharov DA, Spaits M, et al. Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis:Role for tumor suppressor TSC2[J]. Am J Respir Cell Mol Biol, 2006, 34:561-572. doi: 10.1165/rcmb.2005-0300OC [18] Goncharova EA, Goncharov DA, Lim PN, et al. Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis[J]. Am J Respir Cell Mol Biol, 2006, 34:473-480. doi: 10.1165/rcmb.2005-0374OC [19] Weichhart T, Costantino G, Poglitsch M, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response[J]. Immunity, 2008, 29:565-577. doi: 10.1016/j.immuni.2008.08.012 [20] Curatolo P, Moavero R, de Vries PJ. Neurological and neuropsychiatric aspects of tuberous sclerosis complex[J]. Lancet Neurol, 2015, 14:733-745. doi: 10.1016/S1474-4422(15)00069-1 [21] Iyer A, Zurolo E, Prabowo A, et al. MicroRNA-146a:a key regulator of astrocyte-mediated inflammatory response[J]. PLoS One, 2012, 7:e44789. doi: 10.1371/journal.pone.0044789 [22] Aronica E, Fluiter K, Iyer A, et al. Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy[J]. Eur J Neurosci, 2010, 31:1100-1107. doi: 10.1111/j.1460-9568.2010.07122.x [23] Ashhab MU, Omran A, Kong H, et al. Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy[J]. J Mol Neurosci, 2013, 51:950-958. doi: 10.1007/s12031-013-0013-9 [24] Nabbout R, Santos M, Rolland Y, et al. Early diagnosis of subependymal giant cell astrocytoma in children with tuberous sclerosis[J]. J Neurol Neurosurg Psychiatry, 1999, 66:370-375. doi: 10.1136/jnnp.66.3.370 [25] Adriaensen ME, Schaefer-Prokop CM, Stijnen T, et al. Prevalence of subependymal giant cell tumors in patients with tuberous sclerosis and a review of the literature[J]. Eur J Neurol, 2009, 16:691-696. doi: 10.1111/j.1468-1331.2009.02567.x [26] Ciafre SA, Galardi S, Mangiola A, et al. Extensive modulation of a set of microRNAs in primary glioblastoma[J]. Biochem Biophys Res Commun, 2005, 334:1351-1358. doi: 10.1016/j.bbrc.2005.07.030 [27] Kida Y, Han YP. MicroRNA expression in colon adenocarcinoma[J]. JAMA, 2008, 299:2628, 2628-2629. http://cn.bing.com/academic/profile?id=2c746ee9d29b04dd87621dfb78c318fd&encoded=0&v=paper_preview&mkt=zh-cn [28] van Scheppingen J, Iyer AM, Prabowo AS, et al. Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures[J]. Glia, 2016, 64:1066-1082. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=d71399b5b9551ec59d0c78cb813501fe [29] Boer K, Crino PB, Gorter JA, et al. Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors[J]. Brain Pathol, 2010, 20:704-719. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888867/ [30] Prabowo AS, Anink JJ, Lammens M, et al. Fetal brain lesions in tuberous sclerosis complex:TORC1 activation and inflammation[J]. Brain Pathol, 2013, 23:45-59. doi: 10.1111/j.1750-3639.2012.00616.x [31] Prabowo AS, van Scheppingen J, Iyer AM, et al. Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas[J]. J Neuroinflammation, 2015, 12:97. doi: 10.1186/s12974-015-0315-7 [32] Loffler D, Brocke-Heidrich K, Pfeifer G, et al. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer[J]. Blood, 2007, 110:1330-1333. https://www.ncbi.nlm.nih.gov/pubmed/17496199 [33] Gabriely G, Wurdinger T, Kesari S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators[J]. Mol Cell Biol, 2008, 28:5369-5380. doi: 10.1128/MCB.00479-08 [34] Tili E, Michaille JJ, Croce CM. MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer[J]. Immunol Rev, 2013, 253:167-184. doi: 10.1111/imr.12050 [35] Krichevsky AM, Gabriely G. miR-21:a small multi-faceted RNA[J]. J Cell Mol Med, 2009, 13:39-53. http://cn.bing.com/academic/profile?id=8b10584800b1baebaa8d36cccc0f3872&encoded=0&v=paper_preview&mkt=zh-cn [36] Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease[J]. RNA Biol, 2011, 8:706-713. doi: 10.4161/rna.8.5.16154 [37] Moffett HF, Novina CD. A small RNA makes a Bic difference[J]. Genome Biol, 2007, 8:221. doi: 10.1186/gb-2007-8-7-221 [38] Quinn SR, O'Neill LA. A trio of microRNAs that control Toll-like receptor signalling[J]. Int Immunol, 2011, 23:421-425. doi: 10.1093/intimm/dxr034 [39] Tarassishin L, Lee SC. Interferon regulatory factor 3 alters glioma inflammatory and invasive properties[J]. J Neurooncol, 2013, 113:185-194. doi: 10.1007/s11060-013-1109-3 [40] Mei J, Bachoo R, Zhang CL. MicroRNA-146a inhibits glioma development by targeting Notch1[J]. Mol Cell Biol, 2011, 31:3584-3592. doi: 10.1128/MCB.05821-11
点击查看大图
计量
- 文章访问数: 64
- HTML全文浏览量: 20
- PDF下载量: 10
- 被引次数: 0