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抗肿瘤坏死因子α单克隆抗体治疗克罗恩病的关键问题:再读共识

曹倩

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文章导航 > 协和医学杂志  > 2017 >  8(4-5): 207-209
曹倩. 抗肿瘤坏死因子α单克隆抗体治疗克罗恩病的关键问题:再读共识[J]. 协和医学杂志, 2017, 8(4-5): 207-209. doi: 10.3969/j.issn.1674-9081.2017.05.003
引用本文: 曹倩. 抗肿瘤坏死因子α单克隆抗体治疗克罗恩病的关键问题:再读共识[J]. 协和医学杂志, 2017, 8(4-5): 207-209. doi: 10.3969/j.issn.1674-9081.2017.05.003
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Qian CAO. The Crucial Problems in the Treatment of Crohn's Disease with Anti-tumor Necrosis Factor-α Monoclonal Antibody[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 207-209. doi: 10.3969/j.issn.1674-9081.2017.05.003
Citation: Qian CAO. The Crucial Problems in the Treatment of Crohn's Disease with Anti-tumor Necrosis Factor-α Monoclonal Antibody[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 207-209. doi: 10.3969/j.issn.1674-9081.2017.05.003
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抗肿瘤坏死因子α单克隆抗体治疗克罗恩病的关键问题:再读共识

doi: 10.3969/j.issn.1674-9081.2017.05.003

  • 浙江大学医学院附属邵逸夫医院炎症性肠病中心, 杭州 310016

详细信息
    作者简介:

    曹倩  电话：0571-86006642，E-mail：caoq@srrsh.com

  • 中图分类号: R574.1

The Crucial Problems in the Treatment of Crohn's Disease with Anti-tumor Necrosis Factor-α Monoclonal Antibody

  • IBD Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

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    摘要
  • 摘要: 炎症性肠病是一组病因尚不十分明确的慢性非特异性肠道炎症性疾病, 包括溃疡性结肠炎和克罗恩病, 以抗肿瘤坏死因子α单克隆抗体为代表的生物制剂在炎症性肠病中主要用于治疗克罗恩病。《抗肿瘤坏死因子α单克隆抗体治疗炎症性肠病专家共识(2017)》在本期发布, 通过再读新版共识, 重点探讨抗肿瘤坏死因子α单克隆抗体治疗克罗恩病的部分关键问题, 以帮助临床医生提高认识。
    Abstract: Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are chronic nonspecific inflammatory diseases of bowels whose etiology is not clear. Anti-tumor necrosis factor(TNF)-α monoclonal antibody is one of the representative biological agents used for the treatment of Crohn's disease. The "2017 revised Consensus on the Anti-TNF-α Monoclonal Antibody Therapy of Inflammatory Bowel Disease" will be published in current issue. From reviewing the new consensus, the author discussed some key points of anti-TNF-α monoclonal antibody therapy in Crohn's disease, hoping to improve clinical practice of anti-TNF-α monoclonal antibody therapy in Crohn's disease.
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    • 参考文献(9)
  • [1] Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease:the ACCENT I randomised trial[J].Lancet, 2002,359:1541-1549. doi:  10.1016/S0140-6736(02)08512-4
    [2] Sands BE,Anderson FH, Bernstein CN,et al. Infliximab maintenance therapy for fistulizing Crohn's disease[J].N Engl J Med,2004,350:876-885. doi:  10.1056/NEJMoa030815
    [3] Bouguen G, Siproudhis L, Gizard E,et al. Long-term outcome of perianal fistulizing Crohn's disease treated with infliximab[J].Clin Gastroenterol Hepatol,2013,11:975-981. doi:  10.1016/j.cgh.2012.12.042
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    [5] Amiot A, Setakhr V, Seksik P, et al. Long-term outcome of enterocutaneous fistula in patients with Crohn's disease treated with anti-TNF therapy:a cohort study from the GETAID[J]. Am J Gastroenterol,2014,109:1443-1449. doi:  10.1038/ajg.2014.183
    [6] Colombel JF, Sandborn WJ, Reinisch W,et al. Infliximab, azathioprine,or combination therapy for Crohn's disease[J]. N Engl J Med,2010,362:1383-1395. doi:  10.1056/NEJMoa0904492
    [7] Peyrin-Biroulet L, Reinisch W, Colombel JF, et al. Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial[J].Gut,2014,63:88-95. doi:  10.1136/gutjnl-2013-304984
    [8] Waugh AW,Garg S,Matic K,et al.Maintenance of clinical benefit in Crohn's disease patients after discontinuation of infliximab:long-term follow-up of a single centre cohort[J].Aliment pharmacol Ther,2010,32:1129-1134. doi:  10.1111/j.1365-2036.2010.04446.x
    [9] D'Haens GR, Panaccione R, Higgins PD, et al. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization:when to start, when to stop, which drug to choose, and how to predict response?[J]. Am J Gastroenterol,2011,106:199-212. doi:  10.1038/ajg.2010.392
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出版历程
  • 收稿日期:  2017-07-04
  • 刊出日期:  2017-09-30

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