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癫痫最新临床诊疗指南:机遇与挑战并存

肖波 周罗

肖波, 周罗. 癫痫最新临床诊疗指南:机遇与挑战并存[J]. 协和医学杂志, 2017, 8(2-3): 122-126. doi: 10.3969/j.issn.1674-9081.2017.03.008
引用本文: 肖波, 周罗. 癫痫最新临床诊疗指南:机遇与挑战并存[J]. 协和医学杂志, 2017, 8(2-3): 122-126. doi: 10.3969/j.issn.1674-9081.2017.03.008
Bo XIAO, Luo ZHOU. The Latest Clinical Guidelines for Diagnosis and Treatment of Epilepsy: Coexistence of Opportunities and Challenges[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(2-3): 122-126. doi: 10.3969/j.issn.1674-9081.2017.03.008
Citation: Bo XIAO, Luo ZHOU. The Latest Clinical Guidelines for Diagnosis and Treatment of Epilepsy: Coexistence of Opportunities and Challenges[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(2-3): 122-126. doi: 10.3969/j.issn.1674-9081.2017.03.008

癫痫最新临床诊疗指南:机遇与挑战并存

doi: 10.3969/j.issn.1674-9081.2017.03.008
基金项目: 

国家科技部重大研究专项 2016YFC0904400

详细信息
    通讯作者:

    肖波  电话:0731-84327216, E-mail:xiaobo_xy@126.com

  • 中图分类号: R742.1

The Latest Clinical Guidelines for Diagnosis and Treatment of Epilepsy: Coexistence of Opportunities and Challenges

More Information
  • 摘要:

    癫痫是常见的中枢神经系统慢性疾病, 因其致残率高、病程长, 是当前世界范围的医疗难题及社会公共卫生问题。在此背景下, 癫痫临床诊疗指南的制定及推广有助于疾病的规范化诊治, 达到控制癫痫发作并改善患者预后的目的。当前不同国家或地区对疾病的认识程度差距较大, 医疗资源分配不均的现像普遍存在, 因而癫痫临床诊疗指南仍存在较大改进空间。本文就目前最新的癫痫临床诊疗指南作一解读和展望。

  • 表  1  2017国际抗癫痫联盟新版癫痫发作分类

    局灶性起源 全面性起源 未知起源
    运动性 运动性 运动性
       自动症、失张力发作、阵挛发作、癫痫性痉挛、过度运动发作、肌阵挛发作、强直发作    强直-阵挛发作、阵挛发作、强直发作、肌阵挛发作、肌阵挛-强直-阵挛发作、肌阵挛-失张力发作、失张力发作、癫痫性痉挛    运动性强直-阵挛发作、癫痫性痉挛
    非运动性 非运动性(失神发作) 非运动性
       自主神经发作、行为终止、认知发作、情绪发作、感觉性发作    典型发作、非典型发作、肌阵挛发作、眼睑肌阵挛伴失神    行为终止
    局灶性进展为双侧强直-阵挛 其他无法分类
    下载: 导出CSV
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    [2] 中国抗癫痫协会. 临床诊疗指南癫痫病分册(2015修订版)[M].北京:人民卫生出版社,2015:15-16.
    [3] Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy:Position Paper of the ILAE Commission for Classification and Terminology[J]. Epilepsia, 2017,58:522-530. doi:  10.1111/epi.13670
    [4] Krumholz A, Shinnar S, French J, et al. Evidence-based guideline:Management of an unprovoked first seizure in adults:Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society[J]. Neurology, 2015,85:1526-1527. doi:  10.1212/01.wnl.0000473351.32413.7c
    [5] Tao JX, Davis AM. Management of an unprovoked first seizure in adults[J]. JAMA, 2016,316:1590-1591. doi:  10.1001/jama.2016.12047
    [6] Kwan P, Poon WS, Ng HK, et al. Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A:correlation among phenotype, genotype, and mRNA expression[J]. Pharmacogenet Genomics, 2008,18:989-998. doi:  10.1097/FPC.0b013e3283117d67
    [7] Kumari R, Lakhan R, Kumar S, et al. SCN1AIVS5-91G>A polymorphism is associated with susceptibility to epilepsy but not with drug responsiveness[J]. Biochimie, 2013,95:1350-1353. doi:  10.1016/j.biochi.2013.02.006
    [8] Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy:consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies[J]. Epilepsia,2010,6:69-77. http://med.wanfangdata.com.cn/viewHTML/PeriodicalPaper_JJ0216435848.aspx
    [9] 中国医师协会神经内科分会癫痫专委会. 耐药癫痫定义中国专家共识[J].中国医师杂志, 2015,17:964-966. doi:  10.3760/cma.j.issn.1008-1372.2015.07.002
    [10] Fisher RS, Handforth A. Reassessment:vagus nerve stimulation for epilepsy:a report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology[J]. Neurology, 1999,53:666-669. doi:  10.1212/WNL.53.4.666
    [11] Evidence-based guideline update:vagus nerve stimulation for the treatment of epilepsy:report of the Guideline Development Subcommittee of the American Academy of Neurology[J]. Neurology, 2013,8,453-459.
    [12] 中国医师协会神经内科分会癫痫专委会. 迷走神经刺激术治疗癫痫的中国专家共识[J].中国医师杂志,2015,17:976-968. http://www.ixueshu.com/document/c52eb7b044f9bfffc98551788bef76e8318947a18e7f9386.html
    [13] Trinka E,Cock H,Hesdorffer D,et al.A definition and classification of status epilepticus-Report of the ILAE Task Force on Classification of Status Epilepticus[J]. Epilepsia,2015,56:1515-1523. doi:  10.1111/epi.13121
    [14] Tracy G, Shlomo S, David G,et al. Evidence-based guideline:treatment of convulsive status epilepticus in children and adults:Report of the Guideline Committee of the American Epilepsy Society[J]. Epilepsy Currents, 2016,16:48-61. doi:  10.5698/1535-7597-16.1.48
    [15] Richerson GB, Buchanan GF. The serotonin axis:Shared mechanisms in seizures, depression, and SUDEP[J]. Epilepsia, 2011,52:28-38. http://pubmedcentralcanada.ca/pmcc/articles/PMC3052632/
    [16] Cynthia H, Torbjörn T, David G, et al. Practice guideline summary:Sudden unexpected death in epilepsy incidence rates and risk factors:Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society[J].Neurology, 2017,88:1674-1680. doi:  10.1212/WNL.0000000000003685
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出版历程
  • 收稿日期:  2017-05-10
  • 刊出日期:  2020-10-30

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