留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

RhoA/Rho激酶信号通路在慢性疼痛中的作用

丘玥 魏敏 王之遥 黄宇光

丘玥, 魏敏, 王之遥, 黄宇光. RhoA/Rho激酶信号通路在慢性疼痛中的作用[J]. 协和医学杂志, 2016, 7(6): 454-457. doi: 10.3969/j.issn.1674-9081.2016.06.011
引用本文: 丘玥, 魏敏, 王之遥, 黄宇光. RhoA/Rho激酶信号通路在慢性疼痛中的作用[J]. 协和医学杂志, 2016, 7(6): 454-457. doi: 10.3969/j.issn.1674-9081.2016.06.011

RhoA/Rho激酶信号通路在慢性疼痛中的作用

doi: 10.3969/j.issn.1674-9081.2016.06.011
详细信息
    通讯作者:

    黄宇光 电话:010-69155580, E-mail:garybeijing@163.com

  • 中图分类号: R441.1

  • [1] Bishop AL, Hall A. A Rho GTPases and their effector proteins[J]. Biochem J, 2000, 348:241-255. doi:  10.1042/bj3480241
    [2] Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins[J]. Physiol Rev, 2001, 81:153-208. doi:  10.1152/physrev.2001.81.1.153
    [3] Komagome R, Kimura K, Saito M. Postnatal changes in Rho and Rho-related proteins in the mouse brain[J]. Jpn J Vet Res, 2000, 47:127-133. http://www.ncbi.nlm.nih.gov/pubmed/10842919
    [4] Amano M, Chihara K, Nakamura N, et al. The COOH terminus of Rho-kinase negatively regulates rho-kinase activity[J]. J Biol Chem, 1999, 274:32418-32424. doi:  10.1074/jbc.274.45.32418
    [5] Fu X. The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTP S-, and phorbol ester-induced Ca-sensitization of smooth muscle[J]. FEBS Lett, 1998, 440:183-187. doi:  10.1016/S0014-5793(98)01455-0
    [6] Kimura K, Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)[J]. Science, 1996, 273:245-248. doi:  10.1126/science.273.5272.245
    [7] Morin P, Wickman G, Munro J, et al. Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion[J]. Eur J Cell Biology, 2011, 90:13-25. doi:  10.1016/j.ejcb.2010.09.009
    [8] Zhu Y, Casey PJ, Kumar AP, et al. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells:evidence for non-canonical activation of RhoA and Rac1 GTPases[J]. Cell Death Dis, 2013, 4:e568. doi:  10.1038/cddis.2013.103
    [9] Ohsawa M, Aasato M, Hayashi SS, et al. RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice[J]. Pain, 2011, 152:114-122. doi:  10.1016/j.pain.2010.10.005
    [10] Büyükafçar K, Yalçin I, Kurt AH, et al. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice[J]. Eur J Pharmacol, 2006, 541:49-52. doi:  10.1016/j.ejphar.2006.04.042
    [11] Boyce-Rustay JM, Simler GH, McGaraughty S, et al. Characterization of Fasudil in preclinical models of pain[J]. J Pain, 2010, 11:941-949. doi:  10.1016/j.jpain.2009.12.014
    [12] Kamei J, Tamura N, Saitoh A. Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice[J]. Pain, 2005, 117:112-120. doi:  10.1016/j.pain.2005.05.026
    [13] Sousa AM, Prado WA. The dual effect of a nitric oxide donor in nociception[J]. Brain Res, 2001, 897:9-19. doi:  10.1016/S0006-8993(01)01995-3
    [14] Chu LW, Chen JY, Yu KL, et al. Neuroprotective and anti-inflammatory activities of atorvastatin in a rat chronic constriction injury model[J]. Int J Immunopathol Pharmacol, 2012, 25:219-230. doi:  10.1177/039463201202500124
    [15] Clarke RM, O'Connell F, Lyons A, et al. The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-beta1-42 in the rat hippocampus in vivo[J]. Neuropharmacology, 2007, 52:136-145. doi:  10.1016/j.neuropharm.2006.07.031
    [16] Chen XY, Li K, Light AR, et al. Simvastatin attenuates formalin-induced nociceptive behaviors by inhibiting microglial RhoA and p38 MAPK activation[J]. J Pain, 2013, 14:1310-1319. doi:  10.1016/j.jpain.2013.05.011
    [17] Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration[J]. Nature, 2001, 409:341-346. doi:  10.1038/35053072
    [18] Wang KC, Koprivica V, Kim JA, et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth[J]. Nature, 2002, 417:941-944. doi:  10.1038/nature00867
    [19] Jalink K, van Corven EJ, Hengeveld T, et al. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho[J]. J Cell Biol, 1994, 126:801-810. doi:  10.1083/jcb.126.3.801
    [20] Ramer LM, Borisoff JF, Ramer MS. Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy[J]. J Neurosci, 2004, 24:10796-10805. doi:  10.1523/JNEUROSCI.3337-04.2004
    [21] Matsuoka T, Yashiro M. Rho/ROCK signaling in motility and metastasis of gastric cancer[J]. World J Gastroenterol, 2014, 20:13756-13766. doi:  10.3748/wjg.v20.i38.13756
    [22] Burridge K, Wennerberg K. Rho and Rac take center stage[J]. Cell, 2004, 116:167-179. doi:  10.1016/S0092-8674(04)00003-0
    [23] Lowe M. Structural organization of the Golgi apparatus[J]. Curr Opin Cell Biol, 2011, 23:85-93. doi:  10.1016/j.ceb.2010.10.004
    [24] Salvarezza S. LIM kinase 1 and cofilin regulate actin filament population required for dyna- min-dependent apical carrier fission from the trans-Golgi network[J]. Mol Biol Cell, 2009, 20:438-451. doi:  10.1091/mbc.e08-08-0891
    [25] Mittal N, Roberts K, Pal K, et al. Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway[J]. Cell Rep, 2013, 5:1010-1021. doi:  10.1016/j.celrep.2013.10.015
    [26] Yoshimi E, Kumakura F, Hatori C, et al. Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis[J]. J Pharmacol Exp Ther, 2010, 334:955-963. doi:  10.1124/jpet.110.167924
    [27] Dina OA. Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain[J]. Neuron, 2003, 39:613-624. doi:  10.1016/S0896-6273(03)00473-2
    [28] Qiu Y, Chen WY. Wang ZY, et al.Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway[J]. Neurochem Res, 2016, 41:2457-2469. doi:  10.1007/s11064-016-1958-1
    [29] Ohsawa M, Ishikura K, Mutoh J, et al. Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain[J]. Neuroscience, 2016, 333:204-213. doi:  10.1016/j.neuroscience.2016.07.029
    [30] Pearson JT, Jenkins MJ, Edgley AJ, et al. Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation[J]. Cardiovasc Diabetol, 2013, 12:111. doi:  10.1186/1475-2840-12-111
    [31] Matsuoka T, Yashiro M. Rho/ROCK signaling in motility and metastasis of gastric cancer[J]. World J Gastroenterol, 2014, 20:13756-13766. doi:  10.3748/wjg.v20.i38.13756
  • 加载中
计量
  • 文章访问数:  245
  • HTML全文浏览量:  79
  • PDF下载量:  9
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-12-09
  • 刊出日期:  2016-11-30

目录

    /

    返回文章
    返回

    【温馨提醒】近日,《协和医学杂志》编辑部接到作者反映,有多名不法人员冒充期刊编辑发送见刊通知,鼓动作者添加微信,从而骗取版面费的行为。特提醒您,本刊与作者联系的方式均为邮件通知或电话,稿件进度通知邮箱为:mjpumch@126.com,编辑部电话为:010-69154261,请提高警惕,谨防上当受骗!如有任何疑问,请致电编辑部核实。谢谢!