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Establishment of High-precision Irradiation Platform for Scientific Research and Measurement of Radiation Field
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摘要:
目的 建立基于医用加速器的高精度科研辐照平台并对其性能进行评价。 方法 针对科研常用的细胞培养皿设计并制作模体; 针对模体设置加速器参数, 搭建辐照平台; 对该平台的准确性及稳定性、均匀性、安全性等参数进行测量及评价。 结果 本平台在剂量率为600 MU/min时, 处方剂量在0.5~20 Gy之间, 平均剂量偏差在2%以内; 处方剂量在50 Gy水平, 平均剂量偏差为3%~5%。在处方剂量为2 Gy, 剂量率分别为100、200、300、600、1000 MU/min水平时, 辐射场平均剂量偏差在2%以内。在处方剂量为2 Gy、剂量率为600 MU/min水平时, 同一培养皿内最大剂量点与最小剂量点剂量差值为0.05 Gy; 中央培养皿、侧边培养皿及边角培养皿辐射场实际剂量为(2.005±0.012)、(2.002±0.006)、(2.006±0.012)Gy。本平台在正常操作时, 操作室受照剂量接近自然本底剂量; 非正常操作时, 在处方剂量为10 Gy、剂量率为600 MU/min的情况下工作, 距模体10、20、30、50、100、200 cm位置及加速器迷路内的辐照剂量分别为(0.055±0.002)、(0.032±0.002)、(0.023±0.002)、(0.016±0.001)、(0.006±0.001)、(0.004±0.001)、(0.002±0.001)Gy。 结论 该平台具有高剂量精度、高辐射场均匀性、剂量率灵活可调的特点, 并具有极高的安全性, 能够满足绝大多数科研的要求。 Abstract:Objective To establish high-precision irradiation platform for scientific research based on medical accelerator and to evaluate its performance. Methods Phantoms were designed referring to the petri dish commonly used in basic medical research. Irradiation platform was built on the phantoms and parameters of medical accelerator were set for the platform. Parameters for precision, stability, uniformity, and security were measured to evaluate performance of the platform. Results Under the dose rate of 600 MU/minute, and when the prescription dose was between 0.5 Gy and 20 Gy, the mean dose deviation of the platform was within 2%. The mean dose deviation rose to 3% to 5% when the prescription dose was 50 Gy. Under the conditions of prescription dose being 2 Gy, and dose rate being 100, 200, 300, 600, and 1000 MU/minute, the mean dose deviation was within 2%. The difference between maximum and minimum dose of a petri dish was 0.05 Gy under the condition of 600 MU/minute dose rate and 2 Gy prescription dose; while the doses of central, side, and corner petri dishes were (2.005±0.012), (2.002±0.006), and (2.006±0.012) Gy under the same condition. The doses in the operation room were close to the natural background doses when this platform was in normal operating state. When the platform was in abnormal operating state, under the condition of 600 MU/minute dose rate and 10 Gy prescription dose, the doses in position 10, 20, 30, 50, 100, and 200 cm from the phantom and within mazes of the accelerator room were (0.055±0.002), (0.032±0.002), (0.023±0.002), (0.016±0.001), (0.006±0.001), (0.004±0.001), and (0.002±0.001) Gy, respectively. Conclusions The platform can meet the requirements of most scientific researches with its high dose accuracy, high radiation field uniformity, adjustable dose rate, and high safety. -
Key words:
- irradiation platform /
- ionizing radiation
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表 1 不同剂量下辐射场实际剂量(Gy)
照射剂量
(Gy)测量1 测量2 测量3 测量4 测量5 平均值 0.5 0.493 0.501 0.502 0.498 0.497 0.498 1 0.997 0.993 1.005 1.011 1.019 1.005 2 2.009 2.021 1.985 1.991 1.989 1.999 5 4.974 4.989 5.053 5.076 5.023 5.023 10 10.185 9.858 9.959 10.092 10.035 10.026 20 20.383 19.845 19.924 20.086 20.102 20.068 50 51.152 47.939 50.302 46.718 52.209 49.664 
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表 2 不同剂量率下辐射场实际剂量(Gy)
剂量率
(MU/min)测量1 测量2 测量3 测量4 测量5 平均值 100 1.984 1.993 2.021 2.015 1.978 1.998 200 2.019 2.002 1.983 1.997 1.998 2.000 300 1.989 1.988 2.015 2.004 2.002 2.000 600 2.004 2.006 2.015 1.984 2.011 2.004 1000 2.012 2.021 1.993 1.983 1.999 2.002
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表 3 不同位置培养皿辐射场实际剂量(Gy)
培养皿位置 测量1 测量2 测量3 测量4 测量5 平均值 中央 1.992 1.996 2.013 2.021 2.005 2.005 侧边 1.997 1.998 2.005 2.012 1.998 2.002 边角 1.984 1.994 2.014 2.021 2.017 2.006
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表 4 距模体不同距离辐射场实际剂量(Gy)
距模体距离 测量1 测量2 测量3 测量4 测量5 平均值 10 cm 0.055 0.057 0.055 0.053 0.053 0.055 20 cm 0.028 0.033 0.034 0.032 0.032 0.032 30 cm 0.024 0.022 0.020 0.023 0.025 0.023 50 cm 0.016 0.017 0.015 0.014 0.017 0.016 100 cm 0.005 0.006 0.006 0.007 0.007 0.006 200 cm 0.004 0.003 0.004 0.004 0.005 0.004 迷路内 0.002 0.001 0.003 0.002 0.002 0.002
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