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乳腺纤维瘤病的临床病理特征

姜英 常晓燕 陈杰

姜英, 常晓燕, 陈杰. 乳腺纤维瘤病的临床病理特征[J]. 协和医学杂志, 2015, 6(6): 442-445. doi: 10.3969/j.issn.1674-9081.2015.06.009
引用本文: 姜英, 常晓燕, 陈杰. 乳腺纤维瘤病的临床病理特征[J]. 协和医学杂志, 2015, 6(6): 442-445. doi: 10.3969/j.issn.1674-9081.2015.06.009
Ying JIANG, Xiao-yan CHANG, Jie CHEN. Clinicopathological Features of Fibromatosis of the Breast[J]. Medical Journal of Peking Union Medical College Hospital, 2015, 6(6): 442-445. doi: 10.3969/j.issn.1674-9081.2015.06.009
Citation: Ying JIANG, Xiao-yan CHANG, Jie CHEN. Clinicopathological Features of Fibromatosis of the Breast[J]. Medical Journal of Peking Union Medical College Hospital, 2015, 6(6): 442-445. doi: 10.3969/j.issn.1674-9081.2015.06.009

乳腺纤维瘤病的临床病理特征

doi: 10.3969/j.issn.1674-9081.2015.06.009
详细信息
    通讯作者:

    陈杰 电话:010-69159362, E-mail:xhblk@163.com

  • 中图分类号: R365

Clinicopathological Features of Fibromatosis of the Breast

More Information
    Corresponding author: CHEN Jie Tel: 010-69159362, E-mail:xhblk@163.com
  • 摘要:   目的  探讨乳腺纤维瘤病的临床病理特征及鉴别诊断要点。  方法  回顾性分析5例乳腺纤维瘤病患者的临床资料并进行组织形态学、免疫组织化学研究, 对其临床表现、病理形态特点及鉴别诊断进行总结。  结果  5例均为女性, 发病年龄24~75岁, 平均年龄53岁。3例行乳腺病灶活检术, 2例行乳腺单纯切除术。乳腺纤维瘤病由梭形细胞(纤维母细胞/肌纤维母细胞)构成, 背景是丰富的胶原纤维, 有程度不等的玻璃样变性。细胞数量不等, 没有或仅有轻度的细胞不典型性和多形性, 核分裂象少见。免疫组织化学染色5例vimentin均阳性, SMA均部分阳性, 3例β-catenin阳性, 而cytokeratin、desmin、EMA、S-100和CD68均阴性。  结论  乳腺纤维瘤病是一种罕见乳腺肿瘤, 呈进行性、侵袭性生长。
  • 图  1  乳腺纤维瘤病肿瘤组织由梭形细胞构成,背景可见丰富的胶原纤维,有程度不等的玻璃样变性,没有或仅有轻度的细胞不典型性,核分裂象少见(HE染色,×60)

    图  2  乳腺纤维瘤病肿瘤组织中残存的乳腺组织(HE染色,×60)

    图  3  乳腺纤维瘤病肿瘤细胞SMA部分阳性(免疫组织化学染色,×150)

    图  4  乳腺纤维瘤病肿瘤细胞β-catenin阳性(免疫组织化学染色,×150)

    表  1  5例乳腺纤维瘤病患者临床资料

    病例 性别 年龄(岁) 病史 病变部位 超声诊断 术中所见 大小
    1 56 自行发现右乳肿物1月余 右乳外下象限 低回声,形态规则,内见多个条索状中高回声 乳腺及胸大肌中可见4 cm×2 cm×2 cm肿块 4 cm×2 cm×2 cm
    2 24 自行触及右乳肿物半年余 右乳外上象限 低回声,形态不规则,边界不清,内部回声不均 乳腺腺体组织中触及直径约1.7 cm光滑结节 直径1.7 cm
    3 75 无意中发现左乳结节2周 左乳内上象限 乳腺组织可及直径1 cm质硬结节,与胸大肌有粘连,活动可 直径1 cm
    4 66 胸前区瘢痕持续增大30余年,伴局部溢液2年,既往脑膜瘤手术史 双侧乳腺 瘢痕及双侧乳腺单纯切除 直径3 cm
    5 44 发现左乳肿物4个月,既往有2次乳腺错构瘤手术史 左乳乳晕下 乳腺单纯切除 直径4 cm
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出版历程
  • 收稿日期:  2015-08-06
  • 刊出日期:  2015-11-30

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