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AdipoRon:新型小分子脂联素受体激动剂

陈璐 龚凤英 朱惠娟

陈璐, 龚凤英, 朱惠娟. AdipoRon:新型小分子脂联素受体激动剂[J]. 协和医学杂志, 2015, 6(5): 369-371. doi: 10.3969/j.issn.1674-9081.2015.05.011
引用本文: 陈璐, 龚凤英, 朱惠娟. AdipoRon:新型小分子脂联素受体激动剂[J]. 协和医学杂志, 2015, 6(5): 369-371. doi: 10.3969/j.issn.1674-9081.2015.05.011

AdipoRon:新型小分子脂联素受体激动剂

doi: 10.3969/j.issn.1674-9081.2015.05.011
基金项目: 

国家自然科学基金 30540036

国家自然科学基金 30600836

国家自然科学基金 30771026

国家自然科学基金 81370898

国家自然科学基金 81471024

北京市自然科学基金 7082079

国家临床重点专科建设项目 WBYZ2011-873

详细信息
    通讯作者:

    朱惠娟 电话:010-69155073, E-mail:huijuanzhu@hotmail.com

  • 中图分类号: R589.2

  • [1] Gesta S, Tseng YH, Kahn CR. Developmental origin of fat:tracking obesity to its source[J]. Cell, 2007, 131:242-256. doi:  10.1016/j.cell.2007.10.004
    [2] Poulton A, Nanan R. Drugs for the treatment of obesity[J]. JAMA, 2014, 311:1807.
    [3] Balsan GA, Vieira JL, De Oliveira AM, et al. Relationship between adiponectin, obesity and insulin resistance[J]. Rev Assoc Med Bras, 2015, 61:72-80. doi:  10.1590/1806-9282.61.01.072
    [4] Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q, produced exclusively in adipocytes[J]. J Biol Chem, 1995, 270:26746-26749. doi:  10.1074/jbc.270.45.26746
    [5] Li RC, Krishnamoorthy P, Derohannessian S, et al. Psoriasis is associated with decreased plasma adiponectin levels independently of cardiometabolic risk factors[J]. Clin Exp Dermatol, 2014, 39:19-24. doi:  10.1111/ced.12250
    [6] Obeid S, Hebbard L. Role of adiponectin and its receptors in cancer[J]. Cancer Biol Med, 2012, 9:213-220. https://www.ncbi.nlm.nih.gov/pubmed/23691481
    [7] Pajvani UB, Hawkins M, Combs TP, et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity[J]. J Biol Chem, 2004, 279:12152-12162. doi:  10.1074/jbc.M311113200
    [8] Yamauchi T, Nio Y, Maki T, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions[J]. Nat Med, 2007, 13:332-339. doi:  10.1038/nm1557
    [9] Kahn BB, Alquier T, Carling D, et al. AMP-activated protein kinase:ancient energy gauge provides clues to modern understanding of metabolism[J]. Cell Metab, 2005, 1:15-25. doi:  10.1016/j.cmet.2004.12.003
    [10] Tsuchida A, Yamauchi T, Takekawa S, et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue:comparison of activation of PPARalpha, PPARgamma, and their combination[J]. Diabetes, 2005, 54:3358-3370. doi:  10.2337/diabetes.54.12.3358
    [11] Matsunami T, Sato Y, Ariga S, et al. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis[J]. Int J Clin Exp Pathol, 2010, 3:472-481. https://www.ncbi.nlm.nih.gov/pubmed/20606728
    [12] Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity[J]. Nature, 2013, 503:493-499. doi:  10.1038/nature12656
    [13] Mootha VK, Handschin C, Arlow D, et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle[J]. Proc Natl Acad Sci U S A, 2004, 101:6570-6575. doi:  10.1073/pnas.0401401101
    [14] Lee J. Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes[J]. Arch Pharm Res, 2013, 36:208-222. doi:  10.1007/s12272-013-0023-8
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出版历程
  • 收稿日期:  2015-07-17
  • 刊出日期:  2015-09-30

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