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长链非编码RNA及其在胃癌中的作用

于航 杨爱明 陆星华

于航, 杨爱明, 陆星华. 长链非编码RNA及其在胃癌中的作用[J]. 协和医学杂志, 2015, 6(2): 146-149. doi: 10.3969/j.issn.1674-9081.2015.02.014
引用本文: 于航, 杨爱明, 陆星华. 长链非编码RNA及其在胃癌中的作用[J]. 协和医学杂志, 2015, 6(2): 146-149. doi: 10.3969/j.issn.1674-9081.2015.02.014

长链非编码RNA及其在胃癌中的作用

doi: 10.3969/j.issn.1674-9081.2015.02.014
详细信息
    通讯作者:

    杨爱明 电话:010-69155778, E-mail:yangaiming@medmail.com.cn

  • 中图分类号: Q752;R735.2

  • 表  1  长链非编码RNA在不同恶性肿瘤中的异常表达

    lncRNA 恶性肿瘤类型 参考文献
    HOTAIR 肝癌 16
    ANRIL 前列腺癌 17
    ANRIL 前列腺癌 17
    MALAT1 肺癌,肝癌 18-19
    H19 食管癌,乳腺癌,结肠癌 20-22
    GAS5 乳腺癌 23
    HULC 肝癌 24
    BC200 乳腺癌 25
    PRNCR1 前列腺癌 26
    PCGEM1 前列腺癌 27
    lncRNA:长链非编码RNA
    下载: 导出CSV

    表  2  长链非编码RNA在胃恶性肿瘤中的作用

    lncRNA 变化 作用 可能机制 参考文献
    H19 上调 促进细胞增殖 - 28
    lincRNA-00152 上调 - - 29
    MEG3 下调 抑制细胞增殖 激活p53基因 30
    FENDRR 下调 抑制细胞增殖,降低细胞侵袭、转移能力 抑制纤维连接蛋白1的表达 31
    GAS5 下调 抑制细胞增殖、细胞凋亡 抑制E2F1和细胞周期蛋白D1的表达 32
    AC130710 上调 - 通过与miRNA-129-5p相互作用发挥调控作用 33
    ANRIL 上调 促进细胞增殖,抑制细胞凋亡 沉默表达抑癌因子miRNA-99a和miRNA-449a 34
    HMlincRNA717 下调 - - 35
    lncRNA:同表 1;lincRNA:基因间lncRNA; -:未报道
    下载: 导出CSV
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出版历程
  • 收稿日期:  2014-12-03
  • 刊出日期:  2015-03-30

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