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表 1 长链非编码RNA在不同恶性肿瘤中的异常表达
lncRNA 恶性肿瘤类型 参考文献 HOTAIR 肝癌 16 ANRIL 前列腺癌 17 ANRIL 前列腺癌 17 MALAT1 肺癌,肝癌 18-19 H19 食管癌,乳腺癌,结肠癌 20-22 GAS5 乳腺癌 23 HULC 肝癌 24 BC200 乳腺癌 25 PRNCR1 前列腺癌 26 PCGEM1 前列腺癌 27 lncRNA:长链非编码RNA 表 2 长链非编码RNA在胃恶性肿瘤中的作用
lncRNA 变化 作用 可能机制 参考文献 H19 上调 促进细胞增殖 - 28 lincRNA-00152 上调 - - 29 MEG3 下调 抑制细胞增殖 激活p53基因 30 FENDRR 下调 抑制细胞增殖,降低细胞侵袭、转移能力 抑制纤维连接蛋白1的表达 31 GAS5 下调 抑制细胞增殖、细胞凋亡 抑制E2F1和细胞周期蛋白D1的表达 32 AC130710 上调 - 通过与miRNA-129-5p相互作用发挥调控作用 33 ANRIL 上调 促进细胞增殖,抑制细胞凋亡 沉默表达抑癌因子miRNA-99a和miRNA-449a 34 HMlincRNA717 下调 - - 35 lncRNA:同表 1;lincRNA:基因间lncRNA; -:未报道 -
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