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多点实时剂量监测在全身照射中的应用

Application of Multi-point Real-time Dose Monitoring for Total Body Irradiation

    摘要
  • 摘要:
      目的  探讨在有限条件下完成分次双侧位大野全身照射治疗时多点实时剂量监测技术用于质控的必要性。
      方法  使用Varian 2300 C/D加速器6 MV射线对25例准备进行骨髓移植的患者进行全身照射治疗。治疗同时使用半导体剂量计进行多点实时剂量监测, 记录监测结果并与计划计算结果进行比对分析, 在治疗的同时进行剂量的修正, 以确保患者受照剂量误差控制在±5%以内。
      结果  25例患者的12通道首次实时剂量监测结果与理论计划剂量有显著偏差。头部、胸部、腹部、盆腔、大腿、膝关节和踝关节剂量偏差中位数分别为6.10%、-1.30%、5.90%、5.05%、-4.00%、3.05%和3.30%。通过对实时监测数据的分析及时修正偏差, 所有患者的受照剂量偏差均在±5%以内, 上述部位的剂量偏差中位数分别降为0.35%、-1.05%、0.60%、0.20%、-2.55%、1.20%和0.85%。
      结论  实时剂量监测是实施全身照射的必要质控手段。

     

    Abstract:
      Objective  To explore the necessity of multi-point real-time dose monitoring for total body irradiation.
      Methods  Varian 2300 C/D accelerator 6 MV rays were applied on 25 cases ready for bone marrow transplant patients with total body irradiation. Treatment was conducted while using semiconductor dosimeters for multi-point real-time dose monitoring, and the results were monitored and recorded, during which the doses were adjusted to ensure that the radiation dose error was controlled within ±5%.
      Results  The measured dose and calculated dose showed large deviations in the first multi-point real-time dose monitoring of all these 25 patients. The median deviations of the head, chest, abdomen, pelvic, thigh, knee, and ankle were 6.10%, -1.30%, 5.90%, 5.05%, -4.00%, 3.05% and 3.30%, respectively. After timely bias adjustment based on the monitoring results, the dose deviations were within ±5% in all patients, and the median deviations of above mentioned points decreased to 0.35%, -1.05%, 0.60%, 0.20%, -2.55%, 1.20% and 0.85%, respectively.
      Conclusions  Multi-point real-time dose monitoring is necessary for the quality control of total body irradiation.

     

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