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紫外线诱导痤疮患者面部红色荧光物质分布特征

黄文慧,  赵永亮,  王宏伟

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文章导航 > 协和医学杂志  > 2012 >  3(4): 419-422
黄文慧, 赵永亮, 王宏伟. 紫外线诱导痤疮患者面部红色荧光物质分布特征[J]. 协和医学杂志, 2012, 3(4): 419-422. doi: 10.3969/j.issn.1674-9081.2012.04.013
引用本文: 黄文慧, 赵永亮, 王宏伟. 紫外线诱导痤疮患者面部红色荧光物质分布特征[J]. 协和医学杂志, 2012, 3(4): 419-422. doi: 10.3969/j.issn.1674-9081.2012.04.013
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Wen-hui HUANG, Yong-liang ZHAO, Hong-wei WANG. Distribution Feature of Ultraviolet-induced Red Fluorescence on Facial Skin of Patients with Acne[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 419-422. doi: 10.3969/j.issn.1674-9081.2012.04.013
Citation: Wen-hui HUANG, Yong-liang ZHAO, Hong-wei WANG. Distribution Feature of Ultraviolet-induced Red Fluorescence on Facial Skin of Patients with Acne[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 419-422. doi: 10.3969/j.issn.1674-9081.2012.04.013
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紫外线诱导痤疮患者面部红色荧光物质分布特征

doi: 10.3969/j.issn.1674-9081.2012.04.013

  • 中国医学科学院 北京协和医学院 北京协和医院皮肤科, 北京 100730

详细信息
    通讯作者:

    王宏伟 电话:010-69151535, E-mail:18910733256@189.cn

  • 中图分类号: R758.73

Distribution Feature of Ultraviolet-induced Red Fluorescence on Facial Skin of Patients with Acne

  • Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

    摘要
  • 摘要:   目的  研究痤疮患者紫外线诱导面部红色荧光物质的分布特征。  方法  用SAS (skin analysis system)皮肤分析仪拍摄北京协和医院74例痤疮患者和68名健康人面部紫外光图像, 计算红色荧光物质在痤疮患者面部的检出率及其分布。  结果  74例痤疮患者中63例检出面部红色荧光物质, 检出率为85.14%;68名健康人中23名检出红色荧光物质, 检出率为33.82%, 两组比较差异有统计学意义(χ2=39.064, P < 0.005)。两组红色荧光物质在皮脂分泌量高的T区检出率较皮脂分泌量低的U区高, 两组比较差异有统计学意义(χ2=21.806, P < 0.005;χ2=15.429, P < 0.005)。  结论  痤疮患者紫外线诱导红色荧光物质的出现可能与皮脂分泌有关。
    Abstract:   Objective  To study the distribution feature of ultraviolet (UV) -induced red fluorescence on facial skin of the patients with acne.  Methods  The (skin analysis system, SAS) is used to obtain UV images of facial skins of 74 acne patients and 68 healthy individuals, and the detection rate of red fluorescence was calculated.  Results  The detection rate of red fluorescence was 85.14% in 74 acne patients and 33.82% in 68 healthy individuals (χ2=39.064, P < 0.005). Additionally, it was significantly higher in T zone, where sebum secretion is higher, than in U zone, where sebum secretion is lower (χ2=21.806, P < 0.005; χ2=15.429, P < 0.005, respectively).  Conclusion  UV-induced red fluorescence on facial skin of the patients with acne may be related to sebum secretion.
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  • 图  1  痤疮患者典型的紫外线诱导红色荧光分布模式T1U0

    下载: 全尺寸图片 幻灯片

    图  2  痤疮患者典型的紫外线诱导红色荧光分布模式T4U1

    下载: 全尺寸图片 幻灯片

    表  1  痤疮患者各种荧光模式分布

    T区分布类型 U区分布类型
    U0 U1 U2 Total
    T0 11 (14. 9%) 2 (2. 7%) 0 (0%) 13 (17. 6%)
    T1 16 (21. 6%) 2 (2. 7%) 0 (0%) 18 (24. 3%)
    T2 6 (8. 1%) 7 (9. 4%) 0 (0%) 13 (17. 6%)
    T3 2 (2. 7%) 0 (0 %) 0 (0%) 2 (2. 7%)
    T4 4 (5. 4%) 12 (16. 2%) 2 (2. 7%) 18 (24. 3%)
    T5 1 (1. 4%) 4 (5. 4%) 5 (6. 8%) 10 (13. 5%)
    总计 40 (54. 1%) 27 (36. 4%) 7 (9. 5%) 74 (100%)
    下载: 导出CSV
    • 参考文献(15)
  • [1] Han B, Jung B, Nelson JS, et al. Analysis of facial sebum distribution using a digital fluorescent imaging system[J]. J Biomed Opt, 2007, 12:014006. doi:  10.1117/1.2435700
    [2] Borelli C, Merk K, Schaller M, et al. In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment[J]. Acta Derm Venereol, 2006, 86:316-319. doi:  10.2340/00015555-0088
    [3] Pagnoni A, Kligman AM, Kollias N, et al. Digital fluorescence photography can assess the suppressive effect of benzoyl peroxide on Propionibacterium acnes[J]. J Am Acad Dermatol, 1999, 41:710-716. doi:  10.1016/S0190-9622(99)70005-8
    [4] Youn SW, Kim JH, Lee JE, et al. The facial red fluorescence of ultraviolet photography:is this color due to Propionibacterium acnes or the unknown content of secreted sebum?[J]. Skin Res Technol, 2009, 15:230-236. doi:  10.1111/j.1600-0846.2009.00360.x
    [5] Youn SW, Na JI, Choi SY, et al. Regional and seasonal variations in facial sebum secretions:a proposal for the definition of combination skin type[J]. Skin Res Technol, 2005, 11:189-195. doi:  10.1111/j.1600-0846.2005.00119.x
    [6] Choi CW, Choi JW, Park KC, et al. UV induced red fluorescence of the acne patients reflects regional casual sebumlevel and acne lesion distribution:qualitative and quantitative analyses of facial fluorescence[J]. Br J Dermol, 2012, 166:59-66. doi:  10.1111/j.1365-2133.2011.10598.x
    [7] Leyden JJ. Therapy for acne vulgaris[J]. N Engl J Med, 1997, 336:1156-1162. doi:  10.1056/NEJM199704173361607
    [8] Webster GF. The pathophysiology of acne[J]. Cutis, 2005, 76 Suppl 2:4-7. http://europepmc.org/abstract/MED/15903012
    [9] Knor T. The pathogenesis of acne[J]. Acta Dermatovenerol Croat, 2005, 13:44-49.
    [10] Cornelius CE 3rd, Ludwig GD. Red fluorescence of comedones:production of porphyrins by Corynebacterium acnes[J]. J Invest Dermatol, 1967, 49:368-370. doi:  10.1038/jid.1967.150
    [11] Ashkenazi H, Malik Z, Hanh Y, et al. Eradication of Propionibacterium acnes by its Endogenic porphyrins after illumination with high intensity blue light[J]. FEMS Immunol Med Microbiol, 2003, 35:17-24. doi:  10.1111/j.1574-695X.2003.tb00644.x
    [12] Schaller M, Loewenstein M, Borelli C, et al. Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin Ⅲ[J]. Br J Dermatol, 2005, 153:66-71. doi:  10.1111/j.1365-2133.2005.06530.x
    [13] Son T, Han B, Jung B, et al. Fluorescent image analysis for evaluating the condition of facial sebaceous follicles[J]. Skin Res Technol, 2008, 14:201-207. doi:  10.1111/j.1600-0846.2007.00279.x
    [14] Dobrev H. Fluorescence diagnostic imaging in patients with acne[J]. Photodermatol, Photoimmunol Photomed, 2010, 26:285-289. doi:  10.1111/j.1600-0781.2010.00541.x
    [15] 黄文慧, 赵永亮, 王宏伟.红色荧光物质在面部正常皮肤及脂溢性皮炎中的检出[J].中国医学科学院学报, 2012, 34:164-167. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgyxkxyxb201202012
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出版历程
  • 收稿日期:  2012-07-25
  • 刊出日期:  2012-10-30

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