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胰岛素样生长因子与系统性硬皮病的相关性

杜伟,  李芸,  毛笑非,  张涛,  方凯,  孙秋宁

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文章导航 > 协和医学杂志  > 2012 >  3(4): 370-374
杜伟, 李芸, 毛笑非, 张涛, 方凯, 孙秋宁. 胰岛素样生长因子与系统性硬皮病的相关性[J]. 协和医学杂志, 2012, 3(4): 370-374. doi: 10.3969/j.issn.1674-9081.2012.04.002
引用本文: 杜伟, 李芸, 毛笑非, 张涛, 方凯, 孙秋宁. 胰岛素样生长因子与系统性硬皮病的相关性[J]. 协和医学杂志, 2012, 3(4): 370-374. doi: 10.3969/j.issn.1674-9081.2012.04.002
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Wei DU, Yun LI, Xiao-fei MAO, Tao ZHANG, Kai FANG, Qiu-ning SUN. Relationship between Insulin-like Growth Factor and Patients with Systemic Sclerosis[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 370-374. doi: 10.3969/j.issn.1674-9081.2012.04.002
Citation: Wei DU, Yun LI, Xiao-fei MAO, Tao ZHANG, Kai FANG, Qiu-ning SUN. Relationship between Insulin-like Growth Factor and Patients with Systemic Sclerosis[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 370-374. doi: 10.3969/j.issn.1674-9081.2012.04.002
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胰岛素样生长因子与系统性硬皮病的相关性

doi: 10.3969/j.issn.1674-9081.2012.04.002

  • 中国医学科学院 北京协和医学院 北京协和医院皮肤科, 北京 100730

详细信息
    通讯作者:

    孙秋宁 电话:010-69151544, E-mail:sunqnzhy@yahoo.com

  • 中图分类号: R593.25

Relationship between Insulin-like Growth Factor and Patients with Systemic Sclerosis

  • Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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    摘要
  • 摘要:   目的  探讨胰岛素样生长因子(insulin-like growth factor, IGF)与系统性硬皮病(systemic sclerosis, SSc)的关系。  方法  采集2010年至2011年北京协和医院皮肤科就诊的24例SSc患者血清, 其中弥漫型SSc 12例, 局限型SSc 12例; 另外采集12名健康对照者及6例系统性红斑狼疮患者血清, 通过ELISA法检测血清IGF系统各因子的表达, 并结合患者临床资料进行分析。  结果  SSc患者血清IGF-Ⅰ和胰岛素样生长因子结合蛋白(insulin-like growth factor binding protein, IGFBP)-3水平高于健康对照组[分别为(49.21±37.94) ng/ml vs.(15.54±9.07) ng/ml和(3.38±2.09) ng/ml vs.(1.00±0.83) ng/ml, P < 0.001], 且SSc患者血清IGF-Ⅰ与IGFBP-3水平呈正相关(r=0.883, P < 0.001)。血清IGF-Ⅰ和IGFBP-3水平与患者年龄、病程、Rodnan皮肤评分不存在相关性。血清IGF-Ⅰ和IGFBP-3水平在Scl-70抗体阳性与阴性SSc患者间及在肺间质纤维化与无肺间质纤维化SSc患者间差异均无统计学意义。SSc患者血清IGF-Ⅱ、IGFBP-5和IGFBP相关蛋白1(IGFBP-related protein 1, IGFBP-rP1)水平与健康对照组比较差异无统计学意义。  结论  SSc患者血清IGF-Ⅰ和IGFBP-3水平升高, IGF系统可能参与了SSc的发病机制。
    Abstract:   Objective  To analyze the role of insulin-like growth factor (IGF) in patients with systemic sclerosis (SSc) and explore the relationship between these cytokines and the clinical characteristics of SSc.  Methods  Serum samples were obtained from 24 SSc patients[12 patients with diffuse cutaneous SSc (dcSSc) and 12 patients with limited cutaneous SSc (lcSSc)], 12 healthy controls and 6 patients with systemic lupus erythematosus (SLE). The levels of circulating IGF-Ⅰ, IGF-Ⅱ, insulin-like growth factor binding protein (IGFBP)-3, IGFBP-5, IGFBP-related protein 1 (IGFBP-rP1), and transforming growth factor-β1 (TGF-β1) were measured with ELISA kits.  Results  The mean serum IGF-Ⅰ and IGFBP-3 levels were significantly higher in SSc patients than in healthy controls[(49.21±37.94) ng/ml vs. (15.54±9.07) ng/ml; (3.38±2.09) ng/ml vs. (1.00±0.83) ng/ml, both P < 0.001]. A positive correlation between serum IGF-Ⅰ and IGFBP-3 levels was found (r=0.883, P < 0.001). Serum IGF-Ⅰ and IGFBP-3 levels were not associated with age, disease course, and the modified Rodnan total skin thickness score. There were no significant differences in serum IGF-Ⅰ and IGFBP-3 levels between patients with Scl-70 antibody and patients without Scl-70 antibody. Also, the serum IGF-Ⅰ and IGFBP-3 levels showed no significant difference between patients with pulmonary interstitial fibrosis and patients without pulmonary interstitial fibrosis. There were no significant differences in serum IGF-Ⅱ, IGFBP-5, and IGFBP-rP1 levels between patients with SSc and healthy controls.  Conclusion  Serum IGF-Ⅰ and IGFBP-3 levels increase in SSc patients. IGF may play a role in pathogenesis of SSc.
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  • 表  1  系统性硬皮病患者血清胰岛素样生长因子及转化生长因子-β1血清水平

    分组 n IGF-Ⅰ (ng /ml) IGF-Ⅱ (pg /ml) IGFBP-3 (ng /ml) IGFBP-5 (ng /ml) IGFBP-rP1 (ng /ml) TGF-β1 (ng /ml)
    健康对照组 12 15. 54 ± 9. 07 548. 10 ± 350. 29 1. 00 ± 0. 83 87. 20 ± 25. 36 28. 20 ± 11. 01 5. 42 ± 0. 22
    SLE 6 16. 07 ± 7. 78 1952. 37 ± 1887. 49 1. 26 ± 0. 71 71. 97 ± 29. 48 19. 44 ± 7. 70 5. 54 ± 0. 18
    SSc 24 49. 21 ± 37. 94***† 383. 57 ± 302. 03 3. 38 ± 2. 09***† 109. 50 ± 45. 14 31. 33 ± 9. 06†† 7. 46 ± 0. 92***†††
       dcSSc 12 45. 15 ± 24. 64** 393. 51 ± 323. 78 3. 40 ± 2. 26** 106. 64 ± 25. 50 28. 94 ± 7. 98 7. 59 ± 1. 09***
       lcSSc 12 53. 26 ± 48. 65* 373. 64 ± 292. 72 3. 38 ± 2. 02** 112. 37 ± 59. 93 33. 71 ± 9. 78 7. 33 ± 0. 74***
    IGF:胰岛素样生长因子; IGFBP:胰岛素样生长因子结合蛋白; TGF-β1:转化生长因子-β1; IGFBP-rP: IGFBP相关蛋白; SLE:系统性红斑狼疮; SSc:系统性硬皮病; dcSSc:弥漫型系统性硬皮病; lcSSc局限型系统性硬皮病; 与健康对照组比较，* P＜0. 05，**P＜0. 01，***P＜0. 001;与SLE组比较，†P＜0. 05，††P＜0. 01，†††P＜0. 001
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    • 参考文献(17)
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  • 收稿日期:  2012-07-30
  • 刊出日期:  2012-10-30

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