作者投稿
专家审稿
编辑办公
邮件订阅
RSS
-
摘要:
目的 探讨骨促结缔组织增生性纤维瘤的临床表现、病理形态特征及鉴别诊断要点。 方法 报告4例骨促结缔组织增生性纤维瘤并进行组织形态学、免疫组织化学研究, 结合文献对其临床表现、病理形态特点及鉴别诊断进行探讨。 结果 骨促结缔组织增生性纤维瘤病变由梭形细胞(纤维母细胞/肌纤维母细胞)构成, 背景是丰富的胶原纤维, 有程度不等的玻璃样变。细胞数量不等, 没有或仅有轻度的细胞不典型性和多形性, 少见核分裂象。 结论 骨促结缔组织增生性纤维瘤是一种罕见的良性骨肿瘤, 呈进行性、侵袭性, 有时复发。 -
关键词:
- 骨，促结缔组织增生性纤维瘤 /
- 临床病理
Abstract:Objective To investigate the clinicopathological features of solitary desmoplastic fibroma of the bone (DF). Methods Totally 4 cases of DF were confirmed in our hospital from October 2004 to July 2008. Their clinical manifestations as well as the pathologic, morphologic, and immunohistochemical findings were summarized, and relevelant literature was reviewed. Results DF was composed of spindle cells (fibroblasts/myofibroblasts) in a background of numerous thick and wavy collagen fibers of ovoid nuclei dispersed within a collagenous fibers. No mitotic figures, hypercellularity, or pleomorphism was observed. Conclusion DF is a rare benign lesion and can be progressive, invasive, and sometimes recurrent. -
Key words:
- bone, desmoplastic fibroma /
- clinicopathology
-
图 2 骨促结缔组织增生性纤维瘤病变由梭形细胞构成, 背景可见丰富的胶原纤维, 有程度不等的玻璃样变; 没有或仅有轻度的细胞不典型性和多形性, 少见核分裂象(HE, ×60)
表 1 4例骨促结缔组织增生性纤维瘤患者临床资料
表 2 4例骨促结缔组织增生性纤维瘤患者影像学及手术所见
-
[1] Jaffe HL. Tumors and tumorous conditions of the bones and joints[M]. Philadelphia, Pa:Lea & Febiger, 1958:298-303. [2] Schneider M, Zimmermann AC, Depprich RA, et al. Desmoplastic fibroma of the mandible——review of the literature and presentation of a rare case[J]. Head Face Med, 2009, 5:25. doi: 10.1186/1746-160X-5-25 [3] Takazawa K, Tsuchiya H, Yamamoto N, et al. Osteosarcoma arising from desmoplastic fibroma treated 16 years earlier:a case report[J]. J Orthop Sci, 2003, 8:864-868. doi: 10.1007/s00776-003-0725-8 [4] Abdelwahab IF, Klein MJ, Yang DC, et al. Osteosarcoma arising in a desmoplastic fibroma of the proximal tibia[J]. AJR Am J Roentgenol, 2002, 178:613-615. doi: 10.2214/ajr.178.3.1780613 [5] Zhang F, Ni B, Zhao LG, et al. Desmoplastic fibroma of the cervical spine:case report and review of the literature[J]. Spine (Phila Pa 1976), 2010, 35:E667-E671. doi: 10.1097/BRS.0b013e3181cf7073 [6] Min HS, Kang HG, Lee JH, et al. Desmoplastic fibroma with malignant transformation[J]. Ann Diagn Pathol, 2010, 14:50-55. doi: 10.1016/j.anndiagpath.2009.04.004 [7] Brooks MD, Ebbs SR, Colletta AA, et al. Desmoid tumors treated with triphenylethylenes[J]. Eur J Cancer, 1992, 28A:1014-1018. http://www.ncbi.nlm.nih.gov/pubmed/1385717 [8] Dahlin DC, Unni KK. Bone tumors: general aspects and data on 8542 cases[M]. 4th ed. Springfield, IL: Charles C Thomas, 1986. [9] Gebhardt MC, Campbell CJ, Schiller AL, et al. Desmoplastic fibroma of bone:a report of 8 cases and review of the literature[J]. J Bone Joint Surg Am, 1985, 67:732-747. doi: 10.2106/00004623-198567050-00008 [10] Bohm P, Krober S, Greschniok A, et al. Desmoplastic fibroma of bone:a report of two patients, review of the literature, and therapeutic implications[J]. Cancer, 1996, 78:1011-1023. doi: 10.1002/(SICI)1097-0142(19960901)78:5<1011::AID-CNCR11>3.0.CO;2-5 -
下载:
点击查看大图
图(4) / 表(2)
计量
- 文章访问数: 214
- HTML全文浏览量: 104
- PDF下载量: 5
- 被引次数: 0
