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关键词:
- Graves病 /
- 易感基因 /
- 细胞毒性T淋巴细胞相关因子4 /
- 单核苷酸多态性 /
- 促甲状腺激素受体
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Rheumatology (Oxford), 2000, 39:1060-1066. doi: 10.1093/rheumatology/39.10.1060 [6] Kong YC, Brown NK, Flynn JC, et al. Efficacy of HLADRB1* 03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis[J]. J Autoimmun, 2011, 37:63-70. doi: 10.1016/j.jaut.2011.05.010 [7] Ban Y, Davies TF, Greenberg DA, et al. Arginine at position 74 of the HLA-DRb1 chain is associated with Graves' disease[J]. Genes Immun, 2004, 5:203-208. doi: 10.1038/sj.gene.6364059 [8] Yang J, Qin Q, Yan N, et al. CD40 C/T (-1) and CTLA-4 A/G (49) SNPs are associated with autoimmune thyroid diseases in the Chinese population[J/OL]. Endocrine, (2011-08-25)[2011-09-26] http://www.springer.com/?SGWID=0-102-24-0-0&searchType=EASY_CDA&queryText=CD40+C%2FT%28-1%29+and+CTLA-4+A%2FG%2849%29+SNPs+are+associated+with+autoimmune+thyroid+diseases+in+the+Chinese+population. [9] Resetkova E, Kawai K, Enomoto T, et al. Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immuno deficient (SCID) mice[J]. Thyroid, 1996, 6:267-273. doi: 10.1089/thy.1996.6.267 [10] Chen CR, Aliesky HA, Guo J, et al. Blockade of co-stimulation between T cells and antigen-presenting cells:an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus[J]. Thyroid, 2006, 16:427-434. doi: 10.1089/thy.2006.16.427 [11] Jacobson EM, Concepcion E, Oashi T, et al. A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation:a case for translational pathophysiology[J]. Endocrinology, 2005, 146:2684-2691. doi: 10.1210/en.2004-1617 [12] Anjos S, Nguyen A, Ounissi-Benkalha H, et al. 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A genome-wide associa-tion study identifies two new risk loci for Graves' disease[J]. Nat Genet, 2011, 43:897-901. doi: 10.1038/ng.898 [17] Gu LQ, Zhu W, Zhao SX, et al. Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease[J]. Clin Endocrinol (Oxf), 2010, 72:248-255. doi: 10.1111/j.1365-2265.2009.03617.x [18] Collins JE, Heward JM, Carr-Smith J, et al. Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease[J]. J Clin Endocrinol Metab, 2003, 88:5039-5042. doi: 10.1210/jc.2003-030093 [19] Robinson JH, Delvig AA. Diversity in MHC class Ⅱ antigen presentation[J]. Immunology, 2002, 105:252-262. doi: 10.1046/j.0019-2805.2001.01358.x [20] Gebe JA, Swanson E, Kwok WW. HLA class Ⅱ peptidebinding and autoimmunity[J]. Tissue Antigens, 2002, 59:78-87. doi: 10.1034/j.1399-0039.2002.590202.x [21] Davies TF, Ando T, Lin RY, et al. 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