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高分辨磁共振成像用于阿尔茨海默病嗅球体积测量

有慧,  牛富生,  王剑,  郑福玲,  孟春玲,  张振馨,  倪道凤,  冯逢

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文章导航 > 协和医学杂志  > 2011 >  2(3): 209-212
有慧, 牛富生, 王剑, 郑福玲, 孟春玲, 张振馨, 倪道凤, 冯逢. 高分辨磁共振成像用于阿尔茨海默病嗅球体积测量[J]. 协和医学杂志, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
引用本文: 有慧, 牛富生, 王剑, 郑福玲, 孟春玲, 张振馨, 倪道凤, 冯逢. 高分辨磁共振成像用于阿尔茨海默病嗅球体积测量[J]. 协和医学杂志, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
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Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
shu

高分辨磁共振成像用于阿尔茨海默病嗅球体积测量

doi: 10.3969/j.issn.1674-9081.2011.03.004
  • 1.

    中国医学科学院 北京协和医学院 北京协和医院 放射科, 北京 100730

  • 2.

    中国医学科学院 北京协和医学院 北京协和医院 神经内科, 北京 100730

  • 3.

    中国医学科学院 北京协和医学院 北京协和医院 耳鼻喉科, 北京 100730

详细信息
    通讯作者:

    有慧 电话:010-65297440, E-mail:youhuimr77@yahoo.com.cn

  • 中图分类号: R445.2;R749.1+6

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

  • 1.

    Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要:   目的  评价阿尔茨海默病(Alzheimer disease, AD)患者嗅球体积变化。  方法  对14例AD患者及25名正常老年志愿者行高分辨嗅球磁共振成像(magnetic resonance imaging, MRI), 测量嗅球体积。  结果  AD患者较大侧嗅球体积为(32.2±7.7)mm3, 小于正常老年志愿者的(40.6±6.6)mm3(P=0.002)。AD患者嗅球体积与简易精神状态检查量表(mini-mental state examination, MMSE)评分无明显相关性(P=0.205)。  结论  AD患者嗅球体积减小, 符合神经病理学表现。MRI可以发现AD患者嗅球体积改变, 可能为AD诊断提供帮助。
    Abstract:   Objective  To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume.  Methods  Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured.  Results  The OB volume in AD patients[(32.2±7.7) mm3] was significantly smaller than that in control group[(40.6±6.6) mm3](P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205).  Conclusions  AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.
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  • 表  1  AD患者及正常老年志愿者嗅球体积(mm3)

    组别 右侧嗅球体积 左侧嗅球体积 较大侧嗅球体积
    正常志愿者 39. 7 ± 6. 5 37. 2 ± 7. 9 40. 6 ± 6. 6
    AD患者 2. 1 ± 7. 8* 26. 1 ± 10. 3** 32. 2 ± 7. 7***
    AD患者与正常志愿者比较，独立样本t检验，* t = － 3. 022，P = 0. 005; **t = － 3. 523，P = 0. 001; ***t = － 3. 344，P = 0. 002
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    • 参考文献(14)
  • [1] Hof PR, Glannakopoulos P, Bouras C. The neuropathological changes associated with normal brain aging[J]. Histol Histopathol, 1996, 11:1075-1088. http://www.ncbi.nlm.nih.gov/pubmed/8930649
    [2] Wesson DW, Levy E, Nixon RA, et al. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model[J]. J Neurosci, 2010, 13:505-514. http://europepmc.org/articles/PMC2826174/
    [3] Christen-Zaech S, Kraftsik R, Pillevuit O, et al. Early olfactory involvement in Alzheimer's disease[J]. Can J Neurol Sci, 2003, 30:20-25. doi:  10.1017/S0317167100002389
    [4] Attems J, Jellinger KA. Olfactory tau pathology in Alzheimer disease and mild cognitive impairment[J]. Clin Neuropathol, 2006, 25:265-271. http://www.ncbi.nlm.nih.gov/pubmed/17140156
    [5] Attems J, Lintner F, Jellinger KA. Olfactory involvement in aging and Alzheimer's disease:an autopsy study[J]. J Alzheimers Dis, 2005, 7:149-157; discussion 173-180. doi:  10.3233/JAD-2005-7208
    [6] ter Laak HJ, Renkawek K, van Workum FP. The olfactory bulb in Alzheimer disease:a morphologic study of neuron loss, tangles, and senile plaques in relation to olfaction[J]. Alzheimer Dis Assoc Disord, 1994, 8:38-48. doi:  10.1097/00002093-199424003-00005
    [7] McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease:report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease[J]. Neurology, 1984, 34:939-944. doi:  10.1212/WNL.34.7.939
    [8] Handley OJ, Morrison CM, Miles C, et al. ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults[J]. Neurobiol Aging, 2006, 27:1425-1430. doi:  10.1016/j.neurobiolaging.2005.08.001
    [9] Calhoun-Haney R, Murphy C. Apolipoprotein epsilon4 is associated with more rapid decline in odor identification than in odor threshold or Dementia Rating Scale scores[J]. Brain Cogn, 2005, 58:178-182. doi:  10.1016/j.bandc.2004.10.004
    [10] Velayudhan L, Lovestone S. Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil[J]. J Clin Psychopharmacol, 2009, 29:387-390. doi:  10.1097/JCP.0b013e3181aba5a5
    [11] Wilson RS, Arnold SE, Schneider JA, et al. The relationship between cerebral Alzheimer's disease pathology and odour identification in old age[J]. J Neurol Neurosurg Psychiatry, 2007, 78:30-35. doi:  10.1136/jnnp.2006.099721
    [12] Thomann PA, Dos Santos V, Seidl U, et al. MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer's disease[J]. J Alzheimers Dis, 2009, 17:213-221. doi:  10.3233/JAD-2009-1036
    [13] Gomez-Isla T, Price JL, McKeel DW Jr, et al. Profound loss of layer Ⅱ entorhinal cortex neurons occurs in very mild Alzheimer's disease[J]. J Neurosci, 1996, 16:4491-4500. doi:  10.1523/JNEUROSCI.16-14-04491.1996
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出版历程
  • 收稿日期:  2011-04-25
  • 刊出日期:  2011-07-30

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