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胰腺导管上皮内瘤变

常晓燕 李霁 姜英 陈杰

常晓燕, 李霁, 姜英, 陈杰. 胰腺导管上皮内瘤变[J]. 协和医学杂志, 2011, 2(2): 167-171. doi: 10.3969/j.issn.1674-9081.2011.02.017
引用本文: 常晓燕, 李霁, 姜英, 陈杰. 胰腺导管上皮内瘤变[J]. 协和医学杂志, 2011, 2(2): 167-171. doi: 10.3969/j.issn.1674-9081.2011.02.017

胰腺导管上皮内瘤变

doi: 10.3969/j.issn.1674-9081.2011.02.017
基金项目: 

国家自然科学基金 301719109

卫生行业科研专项课题 200802011

详细信息
    通讯作者:

    陈杰 电话:010-65295490, E-mail:xhblk@163.com

  • 中图分类号: R735.9

  • 表  1  胰腺导管上皮内瘤变常见免疫组化标记物

    标记物 着色位置 正常导管 PanIN-1 PanIN-2 PanIN-3
    MUC1[26] 细胞膜 + + ++ +++
    MUC2[26] 细胞膜 - + ++ +++
    MUC5[26] 细胞浆 - +++ +++ +++
    CyclinD1[27] 细胞核 - - - ++
    P53[19] 细胞核 - - - ++
    Ki-67[19] 细胞核 - - + +++
    Fascin[27] 细胞浆 - + ++ +++
    P16[19] 细胞核 + + ++ +++
    下载: 导出CSV
  • [1] American Cancer Society.Cancer facts & figures 2007 [R]. New York: American Cancer Society, 2007: 1-52.
    [2] Jemal A, Murray T, Ward E, et al.Cancer statistics, 2005 [J].CA Cancer J Clin, 2005, 55:10-30. doi:  10.3322/canjclin.55.1.10
    [3] Pisters PW, Wolff RA, Crane CH, et al.Combined-modality treatment for operable pancreatic adenocarcinoma[J]. Oncology, 2005, 19: 393-404, 409 [discussion 409-410, 412-416].
    [4] Yonezawa S, Higashi M, Yamada N, et al.Precursor lesions of pancreatic cancer[J].Gut Liver, 2008, 2:137- 154. doi:  10.5009/gnl.2008.2.3.137
    [5] Hruban RH, Pitman MB, Klimstra DS.Tumors of the pancreas[M] //Atlas of tumor pathology.Fascicle 6. 4 th ed. Washington, DC: American Registry of Pathology and Armed Forces Institute of Pathology, 2007.
    [6] Klimstra DS, Longnecker DS.K-rasmutations in pancreatic ductal proliferative lesions[J].Am J Pathol, 1994, 145: 1547-1550. http://europepmc.org/articles/PMC1887515/
    [7] Aimoto T, Uchida E, Nakamura Y, et al.Multicentric pancreatic intraepithelial neoplasias(PanINs) presenting with the clinical features of chronic pancreatitis[J].J Hepatobiliary Pancreat Surg, 2008, 15:549-553. doi:  10.1007/s00534-007-1269-7
    [8] Sipos B, Frank S, Gress T, et al.Pancreatic in traepithelial neoplasia revisited and updated[J].Pancreatology, 2009, 9:45-54. doi:  10.1159/000178874
    [9] Cubilla AL, Fitzgerald PJ.Morphological lesions associated with human primary invasive nonendocrine pancreas cancer [J].Cancer Res, 1976, 36:2690-2698. http://www.ncbi.nlm.nih.gov/pubmed/1277176
    [10] Tanaka M, Chari S, Adsay NV, et al.International consensus guidelines formanagement of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas[J].Pancreatology, 2006, 6:32. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=4a02666da46e34f6258b4884ad8281d6
    [11] Kern SE, Hruban RH, Hidalgo M, et al.An introduction to pancreatic adenocarcinoma genetics, pathology and therapy [J].Cancer Biol Ther, 2002, 1:607-613. doi:  10.4161/cbt.307
    [12] Recavarren C, Labow DM, Liang J, et al.Histologic characteristics of pancreatic intraepithelial neoplasia associated with different pancreatic lesions[J].Hum Pathol, 2011, 42:18-24. doi:  10.1016/j.humpath.2010.05.022
    [13] Berman JJ, Albores-Saavedra J, Bostwick D, et al.Precancer:A conceptual working definition Results of a Consensus Conference[J].Cancer Detect Prev, 2006, 30:387-394. doi:  10.1016/j.cdp.2006.09.002
    [14] Fukushima N, Sato N, Ueki T, et al.Aberrant methylation of preproen kephalin and p16 genes in pancreatic intraep ithelial neoplasia and pancreatic ductal adenocarcinoma[J]. Am J Pathol, 2002, 160:1573-1581. doi:  10.1016/S0002-9440(10)61104-2
    [15] Shi C, Hong SM, Lim P, et al.KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin[J].Mol Cancer Res, 2009, 7:230- 236. doi:  10.1158/1541-7786.MCR-08-0206
    [16] Laghi L, Orbetegli O, Bianchi P, et al.Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and inbiliary cancers[J].Oncogene, 2002, 21:4301-4306. doi:  10.1038/sj.onc.1205533
    [17] Schutte M, Hruban RH, Geradts J, et al.Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas[J].Cancer Res, 1997, 57:3126-3130. http://www.ncbi.nlm.nih.gov/pubmed/9242437
    [18] Rosty C, Geradts J, Sato N, et al.p16 inactivation in pancreatic intraepithelial neoplasias(PanINs) arising in patients with chronic pancreatitis[J].Am J Surg Pathol, 2003, 27:1495-1501. doi:  10.1097/00000478-200312000-00001
    [19] Karamitopoulou E, Zlobec I, Tornillo L, et al.Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia(PanIN) [J].Pathology, 2010, 42:229-234. http://www.ncbi.nlm.nih.gov/pubmed/20350215
    [20] Wilentz RE, Iacobuzio-Donahue CA, Argani P, et al.Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression[J].Cancer Res, 2000, 60:2002-2006.
    [21] Luttges J, Galehdari H, Brocker V, et al.Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis[J].Am J Pathol, 2001, 158:1677-1683. doi:  10.1016/S0002-9440(10)64123-5
    [22] van Heek NT, Meeker AK, Kern SE, et al.Telomere shortening is nearly universal in pancreatic in traepithelial neoplasia[J].Am J Pathol, 2002, 161:1541-1547. doi:  10.1016/S0002-9440(10)64432-X
    [23] Ueki T, Toyota M, Sohn T, et al.Hypermethylation of multiple genes in pancreatic adenocarcinoma[J].Cancer Res, 2000, 60:1835-1839. http://gut.bmj.com/cgi/ijlink?linkType=ABST&journalCode=canres&resid=60/7/1835
    [24] Park JY, Hong SM, Klimstra DS, et al.Pdx1 Expression in pancreatic precursor lesions and neoplasms[J].Appl Immunoh istochem Mol Morphol, (2011-02-10) [2011-03-02]. http://journals.lww.com/appliedimmunohist/Abstract/publishahead/Pdx1ExpressioninPancreaticPrecursorLesions.99685.aspx.doi:10.1097/PAI.0b013e318206d958
    [25] Bausch D, Thomas S, Mino-Kenudson M, et al.Plectin-1 as a novel biomarker for pancreatic cancer[J].Clin Cancer Res, 2011, 15, 17:302-309. http://gut.bmj.com/cgi/ijlink?linkType=ABST&journalCode=clincanres&resid=17/2/302
    [26] Yonezawa S, Higashi M, Yamada N, et al.Significance of mucin expression in pancreatobiliary neoplasms[J].J Hepatobiliary Pancreat Sci, 2010, 7:108-124. http://www.ncbi.nlm.nih.gov/pubmed/19787286
    [27] Maitra A, Adsay NV, Argani P, et al.Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray [J].Mod Pathol, 2003, 16:902-912. doi:  10.1097/01.MP.0000086072.56290.FB
    [28] Haugk B.Pancreatic intraepithelial neoplasia-can we detect early pancreatic cancer? [J].Histopathology, 2010, 57: 503-514. doi:  10.1111/j.1365-2559.2010.03610.x
    [29] Brune KA, Abe T, Canto MI, et al.Multifocal neoplastic precusor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer[J].Am J Surg Pathol, 2006, 30:1067-1076. http://onlinelibrary.wiley.com/resolve/reference/PMED?id=16931950
    [30] Jarboe EA, Layfield LJ.Cytologic features of pancreatic intraepithelial neoplasia and pancreatitis: potential pitfalls in the diagnosis of pancreatic ductal carcinoma[J].Diagn Cytopathol, (2010-08-20) [2011-03-02 ]. http://onlinelibrary.wiley.com/doi/10.1002/dc.21430.
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出版历程
  • 收稿日期:  2010-06-28
  • 刊出日期:  2011-04-30

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