小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展

王彩红; 刘荣鑫; 汤峰; 魏晓涛; 徐紫清; 侯怀晶; 张杰; 赵永强; 薛建军

doi:10.12290/xhyxzz.2023-0217

小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展

doi: 10.12290/xhyxzz.2023-0217

王彩红¹,
刘荣鑫¹,
汤峰¹,
魏晓涛¹,
徐紫清^{2, 3, 4},
侯怀晶^{2, 3, 4},
张杰^{2, 3, 4},
赵永强^5, ,,
薛建军^{2, 3, 4, ,}

1.
甘肃中医药大学第一临床医学院，兰州 730000
2.
甘肃省中医院麻醉科，兰州 730000
3.
甘肃省中医院甘肃省中西医结合麻醉临床研究中心，兰州 730000
4.
甘肃省中医院甘肃省中医药研究院中西医结合麻醉与循证医学研究所，兰州 730000
5.
甘肃省中医院泌尿外科，兰州 730000

基金项目:

甘肃省科技计划项目-临床医学研究中心建设 20JR10RA435

甘肃省科技计划项目-重点研发计划 22YF7FA101

详细信息

通讯作者:
赵永强, E-mail：1114221808@qq.com

薛建军, E-mail：xjjfei419@163.com

中图分类号: R614.4;R741;R364.5
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- 文章访问数: 583
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- PDF下载量: 105
- 被引次数: 0
出版历程
- 收稿日期: 2023-04-27
- 录用日期: 2023-07-07
- 网络出版日期: 2023-09-04
- 刊出日期: 2023-11-30

Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

WANG Caihong¹,
LIU Rongxin¹,
TANG Feng¹,
WEI Xiaotao¹,
XU Ziqing^{2, 3, 4},
HOU Huaijing^{2, 3, 4},
ZHANG Jie^{2, 3, 4},
ZHAO Yongqiang^{5
, ,},
XUE Jianjun^{2, 3, 4
, ,}

1.
First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, China
2.
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
3.
Gansu Province Integrative Medicine Anesthesia Clinical Research Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
4.
Gansu Provincial Institute of Traditional Chinese and Western Medicine Anesthesia and Evidence-based Medicine Institute, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
5.
Department of Urology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China

Funds:

Gansu Provincial Science and Technology Plan Project-Construction of Clinical Medical Research Center 20JR10RA435

Gansu Provincial Science and Technology Plan Project -Key Research and Development Plan 22YF7FA101

More Information

Corresponding author: ZHAO Yongqiang, E-mail: 1114221808@qq.com; XUE Jianjun, E-mail: xjjfei419@163.com

摘要

摘要: 认知功能障碍作为一种常见的神经系统疾病，以认知减退、记忆力和注意力障碍为主要临床表现，严重影响患者的生存质量，是当前医学研究的热点和难点。认知功能障碍的病因及发病机制复杂多样，研究表明慢性持续性神经炎症在其发生发展中发挥关键作用。小胶质细胞、核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3，NLRP3)炎症小体与神经炎症、认知功能障碍密切相关，调控小胶质细胞、NLRP3炎症小体可减少炎症因子、减少β淀粉样蛋白沉积、调控自噬、维持突触稳态，达到减轻神经炎症，进而防治认知功能障碍的作用。因此，阐明小胶质细胞、NLRP3炎症小体及二者共同在认知功能障碍中的作用机制，可为认知功能障碍相关机制的深入研究及临床防治、药物研发提供参考和依据。
- 小胶质细胞 /
- NLRP3炎症小体 /
- 认知功能障碍 /
- 神经炎症 /
- 研究进展
Abstract: As a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the patients' quality of life. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic persistent neuroinflammation plays a key role in its development. Microglia and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome are closely related to neuroinflammation and cognitive impairment. Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors, reduce amyloid β-protein(Aβ) deposition, regulate autophagy, maintain synaptic homeostasis, thus reducing neuroinflammation and further preventing and treating cognitive impairment. Therefore, exploring the mechanism of microglia and NLRP3 inflammasome as well as their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism and clinical prevention and treatment of cognitive impairment, and the subsequent development of more efficient drugs.
- microglia /
- NLRP3 inflammasome /
- cognitive dysfunction /
- neuroinflammation /
- research progress
注释:

作者贡献：王彩红、薛建军、魏晓涛负责查阅文献及撰写论文；刘荣鑫、汤峰、徐紫清、候怀晶、张杰负责修订论文；王彩红、薛建军、赵永强负责设计选题和审校论文。

利益冲突：所有作者均声明不存在利益冲突

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小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展

doi: 10.12290/xhyxzz.2023-0217

通讯作者:
赵永强, E-mail：1114221808@qq.com

薛建军, E-mail：xjjfei419@163.com

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Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

Corresponding author: ZHAO Yongqiang, E-mail: 1114221808@qq.com; XUE Jianjun, E-mail: xjjfei419@163.com

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留言板

小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展

doi: 10.12290/xhyxzz.2023-0217

通讯作者: 赵永强, E-mail：1114221808@qq.com 薛建军, E-mail：xjjfei419@163.com

计量

出版历程

Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

Corresponding author: ZHAO Yongqiang, E-mail: 1114221808@qq.com; XUE Jianjun, E-mail: xjjfei419@163.com

计量

出版历程

目录

通讯作者:
赵永强, E-mail：1114221808@qq.com

薛建军, E-mail：xjjfei419@163.com