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Introduction and Production Plan of Insulin by Internal Medicine Department of Peking Union Medical College Hospital
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摘要: 胰岛素于1923年进入中国。在其进入中国之前, 北京协和医院内科曾积极引介胰岛素并计划在华生产该药。值胰岛素传入中国100周年之际, 笔者利用馆藏档案、民国医学杂志、北京协和医院年报等史料, 撰写短文追溯了这段鲜为人知的历史, 希望能够丰富药学史、糖尿病史以及北京协和医学院、北京协和医院历史等相关研究。Abstract: Insulin was introduced to China in 1923. Before it entered China, the Internal Medicine Department of Peking Union Medical College Hospital(PUMCH) had actively introduced insulin and planned to produce the drug in China. On the occasion of the 100th anniversary of the introduction of insulin into China, the author accessed the archives of Peking Union Medical College(PUMC), the medical journals, the annual report of PUMCH, and other historical materials to trace this little-known history. The aim is to enrich the history of medicines, the history of diabetes, and the history of the PUMC and PUMCH.利益冲突：作者声明不存在利益冲突
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图 1 怀尔德等在J Metab Res杂志发表的论文[8]
Figure 1. The article written by Wilder and published in J Metab Res
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[1] Ackermann M, Schroeder M, Terry J, et al. Crisis and achievement. 1900 to 1950[M]//Ackermann M E, Schroeder M J, Terry J J, et al. Encyclopedia of World History. New York: Facts on File, 2008. [2] Bliss M. The discovery of insulin[M]. Chicago: University of Chicago Press, 1982: 157, 104-140, 172. [3] 李乃适. 北京协和医院1923年第1例使用胰岛素治疗的糖尿病病历[J]. 中华糖尿病杂志, 2012, 4(1): 56-57. Li N S. The first case of diabetes treated with insulin in Peking Union Medical College Hospital in 1923[J]. Chin J Diabetes Mellitus, 2012, 4(1): 56-57. [4] 张友尚. 胰岛素生产的回顾与展望[J]. 食品与药品, 2008, 10(1): 1-3. doi: 10.3969/j.issn.1672-979X.2008.01.001 Zhang Y S. The production of insulin: retrospect and prospect[J]. Food Drug, 2008, 10(1): 1-3. doi: 10.3969/j.issn.1672-979X.2008.01.001 [5] Banting F G, Best C H, Collip J B, et al. The effect produced on diabetes by extracts of pancreas[J]. Trans Assoc Am Physicians, 1922, 37: 337-347. [6] Goldsmith G A. Russell M. Wilder-a biographical sketch (November, 1885 - December, 1959)[J]. J Nutr, 1961, 74(1): 1-8. doi: 10.1093/jn/74.1.1 [7] Mayo Clinic. A line in the sand-Mayo Clinic's role in insulin research[ EB/OL]. (2015-06-17)[2023-10-07]. https://discoverysedge.mayo.edu/2015/06/17/a-line-in-the-sand-mayo-clinics-role-in-insulin-research-2/ .[8] Wilder R M, Boothby W M, Barborka C J, et al. Clinical observations on insulin[J]. J Metab Res, 1923, 2: 701-728. [9] McLean F C. The present status of insulin therapy in diabetes[J]. Chin Med J, 1923, 37(3): 205-214. [10] Letter to Dr. Macleod 13/10/1922: Insulin Collection, Sanofi Pasteur Limited (formerly Connaught)[A]. Toronto: University of Toronto libraries, 1922. [11] Insulin Committee. Insulin Committee Minutes 17/08/1922 to 29/09/1925, W10028_0016, W10028_0050: Insulin Collection, University of Toronto. Board of Governors[A]. Toronto: University of Toronto libraries, 1922-1923. [12] 15th Annual report of the medical superintendent of the Peking Union Medical College Hospital[R]. Peking: Peking Union Medical College Hospital, 1923: 31, 74. [13] 22th Annual report of the medical superintendent of the Peking Union Medical College Hospital[R]. Peking: Peking Union Medical College Hospital, 1930: 61. [14] 周璇. 我对协和医院营养部的回忆[M]//政协北京市委员会文史资料研究委员会. 话说老协和. 北京: 中国文史出版社, 1987: 385. Zhou X. My memories of the nutrition department of Peking Union Medical College Hospital[M]//The Cultural and Historical Data Research Committee of the Beijing Municipal Committee of the Chinese People's Political Consultative Conference. Talking about the Old Peking Union Medical College Hospital. Beijing: China Culture and History Press, 1987: 385. [15] 杜海琳, 谷晓阳, 李嘉珊. Folin-Wu法发现史研究: 兼论吴宪在其中的贡献[J]. 协和医学杂志, 2022, 13(6): 1114-1120. doi: 10.12290/xhyxzz.2022-0335 Du H L, Gu X Y, Li J S. A study on the invention of Folin-Wu method and Hsien Wu's contribution in the process[J]. Med J PUMCH, 2022, 13(6): 1114-1120. doi: 10.12290/xhyxzz.2022-0335 [16] Loh V. Present status of insulin therapy in diabetes mellitus[J]. Nat Med J, 1924, 10: 391-396. [17] Mills C A. Diabetes among the Chinese; danger of insulin usage[J]. Chin Med J, 1927, 41(11): 914-921. [18] Wang S H. Diabetes mellitus an analysis of 347 cases (Chinese inpatients): part Ⅰ. Incidence symptoms, examination, and complications[J]. Chin Med J, 1937, 51(1): 9-32. [19] Wang S H. Diabetes mellitus an analysis of 347 cases (Chinese inpatients): part Ⅱ. Treatment and prognosis[J]. Chin Med J, 1937, 51(2): 159-178. [20] 张孝骞. 糖尿病座谈总结[J]. 中华医学杂志, 1953, 39(10): 761-762. Zhang X Q. Summary of diabetes symposium[J]. J Chin Med, 1953, 39(10): 761-762. -
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