作者投稿
专家审稿
编辑办公
邮件订阅
RSS
Recent Advance in SPECT Myocardial Perfusion Imaging and Their Clinical Application Values
-
摘要: 基于单光子发射计算机断层显像(single photon emission computed tomography, SPECT)进行的心肌血流灌注成像是冠状动脉疾病的重要常规诊断手段之一。近年来，心脏SPECT成像仪器技术、图像算法技术不断发展，心肌血流定量评估成为技术与临床结合的研究热点。本文通过回顾心脏SPECT系统在探测器技术、系统结构、准直技术、图像重建算法以及心肌血流定量化方法等方面的发展路线，简要阐述近年来的研究热点和进展，以及新仪器技术水平进步所带来的临床应用价值提升。
-
关键词:
- 单光子发射计算机断层显像 /
- 心肌血流灌注成像 /
- 探测器 /
- 图像重建 /
- 定量化 /
-
Abstract: Myocardial perfusion single photon emission computed tomography (SPECT) imaging is an important routine diagnostic modality for coronary artery disease. In recent years, there have been continuous advancements in cardiac SPECT imaging instrument technology and image algorithm techniques, with a growing focus on quantitative assessment of myocardial blood flow, a research hotspot that integrates technical and clinical research. This article provides an overview of the development path of cardiac SPECT systems in terms of detector technology, system structure, collimation techniques, as well as SPECT image reconstruction algorithms and myocardial blood flow quantification methods. We briefly discuss the recent research hotspots and progress, highlighting the clinical value enhancement made possible by advancements in instrument technology.-
Key words:
- SPECT /
- myocardial perfusion imaging /
- radiation detector /
- electronics /
- image reconstruction /
- quantification
作者贡献：马天予负责全文构思，探测器技术、准直技术、算法技术、总结部分内容撰写及审校；张德斌负责准直技术、临床应用部分、总结部分内容撰写、插图绘制及审校；王瑞负责成像系统性能内容撰写；程李负责心肌血流定量化部分内容撰写及插图绘制。利益冲突：所有作者均声明不存在利益冲突 -
表 1 典型心脏专用SPECT系统特性对比
指标 D-SPECT NM 530c IQ·SPECT Cardius® 3XPO 探测器 CZT CZT NaI(Tl)+PMT CsI(Tl)+光电二极管 准直器 平行孔 多针孔 SMARTZOOM 心脏扇束 采集时间(min) 6 10 4.5 7.5 灵敏度(cps/MBq) 850 460 390 324 分辨率(mm) 8.6 6.7 15 9.2 SPECT: 单光子发射计算机断层显像；CZT: 半导体碲锌镉；NaI(TI): 掺铊碘化钠；PMT: 晶体耦合光电倍增管；CsI(Tl): 掺铊碘化铯 
下载: 导出CSV
-
[1] Brown JC, Gerhardt TE, Kwon E. Risk Factors For Coronary Artery Disease[M]. Treasure Island (FL): StatPearls, 2022. [2] 中华人民共和国国家卫生健康委员会. 2022中国卫生健康统计年鉴[EB/OL]. (2023-05-17)[2023-06-30]. http://www.nhc.gov.cn/mohwsbwstjxxzx/tjtjnj/202305/6ef68aac6bd14c1eb9375e01a0faa1fb.shtml .[3] 国家心血管病中心. 中国心血管病报告2022[M/OL]. (2022)[2023-06-30]. https://www.nccd.org.cn/News/Information/Index/1089 .[4] Dewey M, Siebes M, Kachelrieβ M, et al. Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia[J]. Nat Rev Cardiol, 2020, 17: 427-450. doi: 10.1038/s41569-020-0341-8 [5] Dorbala S, Ananthasubramaniam K, Armstrong IS, et al. Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation[J]. J Nucl Cardiol, 2018, 25: 1784-1846. doi: 10.1007/s12350-018-1283-y [6] Erlandsson K, Kacperski K, van Gramberg D, et al. Performance evaluation of D-SPECT: a novel SPECT system for nuclear cardiology[J]. Phys Med Biol, 2009, 54: 2635-2649. doi: 10.1088/0031-9155/54/9/003 [7] Hutton BF, Erlandsson K, Thielemans K. Advances in clinical molecular imaging instrumentation[J]. Clin Transl Imaging, 2018, 6: 31-45. doi: 10.1007/s40336-018-0264-0 [8] Bocher M, Blevis IM, Tsukerman L, et al. A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential[J]. Eur J Nucl Med Mol Imaging, 2010, 37: 1887-1902. doi: 10.1007/s00259-010-1488-z [9] Slomka PJ, Berman DS, Germano G. New Cardiac Cameras: Single-Photon Emission CT and PET[J]. Semin Nucl Med, 2014, 44: 232-251. doi: 10.1053/j.semnuclmed.2014.04.003 [10] Nakajima K, Okuda K, Momose M, et al. IQ·SPECT technology and its clinical applications using multicenter normal databases[J]. Ann Nucl Med, 2017, 31: 649-659. doi: 10.1007/s12149-017-1210-3 [11] Vija AH, Malmin R, Yahil A, et al. A method for improving the efficiency of myocardial perfusion imaging using conventional SPECT and SPECT/CT imaging systems[C]. IEEE Nuclear Science Symposuim & Medical Imaging Conference, 2010. [12] Imbert L, Poussier S, Franken PR, et al. Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images[J]. J Nucl Med, 2012, 53: 1897. doi: 10.2967/jnumed.112.107417 [13] Chaudhari AJ, Badawi RD. Application-specific nuclear medical in vivo imaging devices[J]. Phys Med Biol, 2021, 66: 10TR01. doi: 10.1088/1361-6560/abf275 [14] Wu J, Liu C. Recent advances in cardiac SPECT instrumentation and imaging methods[J]. Phys Med Biol, 2019, 64: 06TR01. doi: 10.1088/1361-6560/ab04de [15] Gambhir SS, Berman DS, Ziffer J, et al. A Novel High-Sensitivity Rapid-Acquisition Single-Photon Cardiac Imaging Camera[J]. J Nucl Med, 2009, 50: 635-643. doi: 10.2967/jnumed.108.060020 [16] DePuey EG. Advances in SPECT camera software and hardware: Currently available and new on the horizon[J]. J Nucl Cardiol, 2012, 19: 551-581. doi: 10.1007/s12350-012-9544-7 [17] Mao Y, Yu Z, Zeng GL. Segmented slant hole collimator for stationary cardiac SPECT: Monte Carlo simulations[J]. Med Phys, 2015, 42: 5426-5434. doi: 10.1118/1.4928484 [18] Hui L, Jing W, Si C, et al. Development of stationary dedicated cardiac SPECT with multi-pinhole collimators on a clinical scanner[C]. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2015. [19] Ogawa K, Ichimura Y. Simulation study on a stationary data acquisition SPECT system with multi-pinhole collimators attached to a triple-head gamma camera system[J]. Ann Nucl Med, 2014, 28: 716-724. doi: 10.1007/s12149-014-0865-2 [20] Bowen JD, Huang Q, Ellin JR, et al. Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications[J]. Phys Med Biol, 2013, 58: 7209-7226. doi: 10.1088/0031-9155/58/20/7209 [21] Chang W, Ordonez CE, Liang H, et al. C-SPECT—A Clinical Cardiac SPECT/Tct Platform: Design Concepts and Performance Potential[J]. IEEE Trans Nucl Sci, 2009, 56: 2659-2671. doi: 10.1109/TNS.2009.2028138 [22] Kalluri K, Bhusal N, Shumilov D, et al. Multi-pinhole cardiac SPECT performance with hemi-ellipsoid detectors for two geometries[C]. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2015. [23] Patton JA, Slomka PJ, Germano G, et al. Recent technologic advances in nuclear cardiology[J]. J Nucl Cardiol, 2007, 14: 501-513. doi: 10.1016/j.nuclcard.2007.06.003 [24] Acampa W, Zampella E, Assante R, et al. Quantification of myocardial perfusion reserve by CZT-SPECT: A head to head comparison with 82Rubidium PET imaging[J]. J Nucl Cardiol, 2021, 28: 2827-2839. doi: 10.1007/s12350-020-02129-w [25] Zhang D, Lyu Z, Liu Y, et al. Characterization and assessment of projection probability density function and enhanced sampling in self-collimation SPECT[J]. IEEE Trans Med Imaging, 2023. doi: 10.1109/TMI.2023.3265874. [26] Zhang D, Zheng X, Hu Y, et al. Feasibility study of a self-collimating SPECT for fast dynamic cardiac imaging[J]. J Nucl Med, 2022, 63: 2338. [27] Qi W, Yang Y, Song C, et al. 4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT[J]. IEEE Trans Med Imaging, 2017, 36: 1626-1635. doi: 10.1109/TMI.2017.2690819 [28] Dickson J, Ross J, Vöö S. Quantitative SPECT: the time is now[J]. EJNMMI Phys, 2019, 6: 4. doi: 10.1186/s40658-019-0241-3 [29] Miyaji N, Miwa K, Tokiwa A, et al. Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm[J]. EJNMMI Res, 2020, 10: 71. doi: 10.1186/s13550-020-00659-5 [30] D'Ambrosio L, Aloj L, Chiaramida P, et al. Quantitative SPECT/CT imaging using a commercial software[J]. Phys Med: Eur J Med Phys, 2016, 32: 102-103. [31] Dickson JC, Armstrong IS, Gabiña PM, et al. EANM practice guideline for quantitative SPECT-CT[J]. Eur J Nucl Med Mol Imaging, 2023, 50: 980-995. doi: 10.1007/s00259-022-06028-9 [32] Peters SM, van der Werf NR, Segbers M, et al. Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study[J]. EJNMMI Phys, 2019, 6: 29. doi: 10.1186/s40658-019-0268-5 [33] Fukai S, Daisaki H, Umeda T, et al. Impact of patient body habitus on image quality and quantitative value in bone SPECT/CT[J]. Ann Nucl Med, 2022, 36: 586-595. doi: 10.1007/s12149-022-01746-4 [34] Hsu B, Hu LH, Yang BH, et al. SPECT myocardial blood flow quantitation toward clinical use: a comparative study with (13)N-Ammonia PET myocardial blood flow quantitation[J]. Eur J Nucl Med Mol Imaging, 2017, 44: 117-128. doi: 10.1007/s00259-016-3491-5 [35] Michopoulou S, O'Shaughnessy E, Thomson K, et al. Discovery Molecular Imaging Digital Ready PET/CT perfor-mance evaluation according to the NEMA NU2-2012 standard[J]. Nucl Med Commun, 2019, 40: 270-277. doi: 10.1097/MNM.0000000000000962 [36] Nudi F, Biondi-Zoccai G, Nudi A, et al. Comparative analysis between myocardial perfusion reserve and maximal ischemia score at single photon emission computed tomography with new-generation cadmium-zinc-telluride cameras[J]. J Nucl Cardiol, 2021, 28: 1072-1084. doi: 10.1007/s12350-019-01764-2 [37] Shiraishi S, Tsuda N, Sakamoto F, et al. Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging[J]. J Cardiol, 2020, 75: 400-409. doi: 10.1016/j.jjcc.2019.09.006 [38] Nudi F, Biondi-Zoccai G, Nudi A, et al. Comparative analysis between myocardial perfusion reserve and maximal ischemia score at single photon emission computed tomography with new-generation cadmium-zinc-telluride cameras[J]. J Nucl Cardiol, 2021, 28: 1072-1084. doi: 10.1007/s12350-019-01764-2 [39] Fang W, Hsu B. Myocardial blood flow quantitation with the SPECT technique: Is it ready to be a substitute for PET myocardial blood flow quantitation? [J]. J Nucl Cardiol, 2022, 29: 3152-3154. doi: 10.1007/s12350-021-02697-5 [40] Giubbini R, Bertoli M, Durmo R, et al. Comparison between N13NH3-PET and 99mTc-Tetrofosmin-CZT SPECT in the evaluation of absolute myocardial blood flow and flow reserve[J]. J Nucl Cardiol, 2021, 28: 1906-1918. doi: 10.1007/s12350-019-01939-x [41] D'Antonio A, Assante R, Zampella E, et al. Myocardial blood flow evaluation with dynamic cadmium-zinc-telluride single-photon emission computed tomography: Bright and dark sides[J]. Diagn Interv Imaging, 2023, 104: 323-329. doi: 10.1016/j.diii.2023.02.001 [42] de Souza ACDAH, Harms HJ, Martell L, et al. Accuracy and Reproducibility of Myocardial Blood Flow Quantification by Single Photon Emission Computed Tomography Imaging in Patients With Known or Suspected Coronary Artery Disease[J]. Circ Cardiovasc Imaging, 2022, 15: e013987. [43] Knott KD, Seraphim A, Augusto JB, et al. The Prognostic Significance of Quantitative Myocardial Perfusion[J]. Circulation, 2020, 141: 1282-1291. [44] Camici PG, d'Amati G, Rimoldi O. Coronary microvascular dysfunction: mechanisms and functional assessment[J]. Nat Rev Cardiol, 2015, 12: 48-62. doi: 10.1038/nrcardio.2014.160 [45] Taqueti VR, Di Carli MF. Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review[J]. J Am Coll Cardiol, 2018, 72: 2625-2641. doi: 10.1016/j.jacc.2018.09.042 [46] Maron DJ, Hochman JS, Reynolds HR, et al. Initial Invasive or Conservative Strategy for Stable Coronary Disease[J]. N Engl J Med, 2020, 382: 1395-1407. doi: 10.1056/NEJMoa1915922 [47] Ford Thomas J, Ong P, Sechtem U, et al. Assessment of Vascular Dysfunction in Patients Without Obstructive Coronary Artery Disease[J]. JACC Cardiovasc Interv, 2020, 13: 1847-1864. [48] Del Buono Marco G, Montone Rocco A, Camilli M, et al. Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases[J]. J Am Coll Cardiol, 2021, 78: 1352-1371. doi: 10.1016/j.jacc.2021.07.042 -
点击查看大图
图(2) / 表(1)
计量
- 文章访问数: 1669
- HTML全文浏览量: 53
- PDF下载量: 141
- 被引次数: 0
