作者投稿
专家审稿
编辑办公
邮件订阅
RSS
-
摘要:
目的 探讨自体毛囊单位提取(follicular unit extraction, FUE)毛发移植术治疗男性雄激素性脱发(androgenetic alopecia, AGA)的临床效果。 方法 本研究为回顾性分析, 研究对象为2016年8月-2018年9月西安医学院第一附属医院整形烧伤美容科行FUE毛发移植术的男性AGA患者。移植术后1年时, 测量受区存活的毛发密度并计算毛囊存活率, 以评估临床疗效; 记录移植术后并发症发生情况、患者满意度及移植前后生活质量评分。 结果 共入选符合纳入与排除标准的男性AGA患者126例, 平均年龄为(37±9.05)岁; 平均病程为(10±2.76)年; Hamilton-Norwood Ⅱ级5例, Ⅲ级55例, Ⅳ级54例, Ⅴ级10例, Ⅵ级2例。移植术后1年时, 前发际、头顶处存活的毛发密度分别为(65±7) FUs/cm2、(43±4) FUs/cm2; 毛囊存活率均>90%(其中107例患者毛囊存活率>95%), 有效率为100%(126/126);均无严重并发症发生, 患者满意率为97.6%(123/126)。移植术后1年时, 126例AGA患者生活质量综合评定量表-74中的躯体功能、心理功能、社会功能和物质生活状态评分均较术前明显提高(P均 < 0.01)。 结论 FUE毛发移植术具有安全性好、毛囊移植后存活率高的特点, 治疗男性AGA有效率高并可提高生活质量, 患者满意度高。 Abstract:Objective To explore the clinical application of follicular unit extraction (FUE) hair transplantation in male androgen alopecia (AGA). Methods From August 2016 to September 2018, male AGA patients operated with FUE hair transplantation in the First Affiliated Hospital of Xi'an Medical University were retrospectively analyzed.At one year after transplantation, clinical curative effect was evaluated by the survival hair density and follicles rate of FUE transplantation, meanwhile surgical complications, patient satisfaction rate and life quality score were measured and analyzed. Results A total of 126 male AGA patients who met the inclusion and exclusion criteria were included, with average age was (37±9.05) years and average disease course was (10±2.76) years.According to the Hamilton-Norwood grade standard, there were 5 grade Ⅱpatients, 55 grade Ⅲ patients, 54 grade Ⅳ patients, 10 grade Ⅴ patients, and 2 grade Ⅵ patients.At one year after transplantation, viable hair density on the anterior hairline and the top of the head was (65±7) FUs/cm2 and (43±4) FUs/cm2, respectively.The survival rate of hair follicles was more than 90%, even more than 95% among the 107 AGA patients.The effective rate was 100%(126/126), no serious complications occurred, and the satisfaction rate of patients was 97.6%(123/126).Besides, the scores of physical function, psychological function, social function and material life status of 126 AGA patients were significantly increased than those before transplantation (all P < 0.01). Conclusions FUE hair transplantation has significant clinical effect, and is highly safe and effective.With the potential to dramatically improve life quality, it can be widely applied in treatment of AGA. -
Key words:
- androgenetic alopecia /
- follicular unit extraction /
- hair transplantation /
- hair follicle /
- hair density
作者贡献：王芳负责论文撰写；陈莹、雷惠斌、张惠丰、何洁、李萌、雷婷负责手术操作及资料收集；张伟负责研究设计及论文修订。利益冲突：所有作者均声明不存在利益冲突 -
图 1 例1, 患者33岁，因工作强度及压力大，致头发脱落7年余，前发际及两侧额角后退、上移均约2 cm，可见油亮头皮，脱发面积约36 cm2，确诊为AGA(Hamilton-Norwood Ⅲ级)，移植约1750 FU(2700根毛囊)，术后6个月存活毛发密度为(43±3)FUs/cm2，对治疗效果非常满意
A.术前；B.移植术后即刻；C.移植术后6个月AGA：雄激素性脱发；FU：毛囊单位
图 2 例2，患者48岁，因工作压力大及生活习惯差，致头发脱落15年余，前发际及两侧额角后退、上移均约4.5 cm，头顶毛发明显稀疏，可见油亮头皮，脱发面积约126 cm2，确诊为AGA(Hamilton-Norwood Ⅳ级)，移植约3400 FU(4700根毛囊)，术后18个月存活毛发密度为(60±5)FUs/cm2，对治疗效果非常满意
A.术前；B.移植术后即刻；C.移植术后18个月
AGA、FU：同图 1 -
[1] 中国医师协会美容与整形医师分会毛发整形美容专业委员会. 中国人雄激素性脱发诊疗指南[J]. 中国美容整形外科杂志, 2019, 30: 前插2-6. doi: 10.3969/j.issn.1673-7040.2019.01.001 [2] Gupta AK, Venkataraman M, Talukder M, et al. Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis[J]. JAMA Dermatol, 2022, 158: 266-274. doi: 10.1001/jamadermatol.2021.5743 [3] Zhao Z, Tian Q, Zhang B. Effects of rehabilitation nursing care on deep vein thrombosis of the lower limbs following spinal fractures[J]. Am J Transl Res, 2021, 13: 1877-1883. [4] 尹梓贻, 曹国荣, 刘举利, 等. 瘢痕性秃发实施高密度毛发移植技术的治疗效果研究[J]. 中国医疗美容杂志, 2019, 9: 27-31. https://www.cnki.com.cn/Article/CJFDTOTAL-YLMR201905008.htm [5] Ghonemy S, Alarawi A, Bessar H. Efficacy and safety of a new 10% topical minoxidil versus 5% topical minoxidil and placebo in the treatment of male androgenetic alopecia: a trichoscopic evaluation[J]. J Dermatolog Treat, 2021, 32: 236-241. doi: 10.1080/09546634.2019.1654070 [6] 张阳冰. 男性雄激素性脱发的BASP分型及疗效分析[D]. 广东. 广州医科大学, 2018. [7] 赵钧, 周圳滔, 张菊芳, 等. 毛发移植技术重建发际线的临床研究进展[J]. 组织工程与重建外科杂志, 2020, 16: 260-262. doi: 10.3969/j.issn.1673-0364.2020.03.022 [8] Gan YY, Du LJ, Hong WJ, et al. Theoretical basis and clinical practice for FUE megasession hair transplantation in the treatment of large area androgenic alopecia[J]. J Cosmet Dermatol, 2021, 20: 210-217. doi: 10.1111/jocd.13432 [9] Edoardo R, Giorgia C. Scalp Surgery: Quantitative Analysis of Follicular Unit Growth[J]. Plast Reconstr Surg Glob Open, 2015, 3: e539. doi: 10.1097/GOX.0000000000000524 [10] Vasudevan B, Neema S, Ghosh K, et al. Hair transplanta-tion by follicular unit extraction for male androgenetic alopecia: A retrospective observational study from two centers[J]. Med J Armed Forces India, 2020, 76: 430-437. doi: 10.1016/j.mjafi.2019.11.001 [11] Garg AK, Garg S. Donor harvesting: follicular unit excision[J]. J Cutan Aesthet Surg, 2018, 11: 195-201. doi: 10.4103/JCAS.JCAS_123_18 [12] 张宝良, 施耘, 曹丽红, 等. 毛发移植发展现状[J]. 国际生物医学工程杂志, 2020, 43: 80-85. https://www.cnki.com.cn/Article/CJFDTOTAL-YLMR202007019.htm [13] Nadimi S. Complications with Hair Transplantation[J]. Facial Plast Surg Clin North Am, 2020, 28: 225-235. doi: 10.1016/j.fsc.2020.01.003 [14] Chen HA, Pan JY, Chiang CH, et al. New idea for hair transplantation to preserve more donor hair follicles[J]. Med Hypotheses, 2019, 128: 83-85. doi: 10.1016/j.mehy.2019.05.018 [15] 邱月棨, 付思祺, 罗帅寒天, 等. 2020年雄激素性脱发的研究进展[J]. 中华皮肤科杂志, 2021, 54: 835-838. [16] Umar S, Shitabata P, Rose P, et al. A New Universal Follicular Unit Excision Classification System for Hair Transplantation Difficulty and Patient Outcome[J]. Clin Cosmet Investig Dermatol, 2022, 15: 1133-1147. doi: 10.2147/CCID.S369346 [17] Jimenez F, Alam M, Vogel JE, et al. Hair transplantation: Basic overview[J]. J Am Acad Dermatol, 2021, 85: 803-814. doi: 10.1016/j.jaad.2021.03.124 [18] 苗勇, 朱德聪, 樊哲祥, 等. 移植胡须毛囊单位治疗男性雄激素性脱发[J]. 中华整形外科杂志, 2020, 36: 606-611. doi: 10.3760/cma.j.cn114453-20200407-00203 -
下载:
点击查看大图
图(2) / 表(1)
计量
- 文章访问数: 150
- HTML全文浏览量: 52
- PDF下载量: 27
- 被引次数: 0
