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关注胃肠道黏膜屏障,规范黏膜保护剂应用——《胃肠道黏膜保护临床专家共识(2021年,福州)》解读

李景南

李景南. 关注胃肠道黏膜屏障,规范黏膜保护剂应用——《胃肠道黏膜保护临床专家共识(2021年,福州)》解读[J]. 协和医学杂志, 2022, 13(5): 796-799. doi: 10.12290/xhyxzz.2022-0256
引用本文: 李景南. 关注胃肠道黏膜屏障,规范黏膜保护剂应用——《胃肠道黏膜保护临床专家共识(2021年,福州)》解读[J]. 协和医学杂志, 2022, 13(5): 796-799. doi: 10.12290/xhyxzz.2022-0256
LI Jingnan. Gastrointestinal Mucosal Barrier and Standardization of the Application of Mucosal Protective Agents: Interpretation on the Consensus of Clinical Experts on Gastrointestinal Mucosal Protection(2021, Fuzhou)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 796-799. doi: 10.12290/xhyxzz.2022-0256
Citation: LI Jingnan. Gastrointestinal Mucosal Barrier and Standardization of the Application of Mucosal Protective Agents: Interpretation on the Consensus of Clinical Experts on Gastrointestinal Mucosal Protection(2021, Fuzhou)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 796-799. doi: 10.12290/xhyxzz.2022-0256

关注胃肠道黏膜屏障,规范黏膜保护剂应用——《胃肠道黏膜保护临床专家共识(2021年,福州)》解读

doi: 10.12290/xhyxzz.2022-0256
详细信息
    作者简介:

    李景南, E-mail: lijn2008@126.com

  • 中图分类号: R816.5; R975

Gastrointestinal Mucosal Barrier and Standardization of the Application of Mucosal Protective Agents: Interpretation on the Consensus of Clinical Experts on Gastrointestinal Mucosal Protection(2021, Fuzhou)

More Information
  • 摘要: 胃肠道是人体与外界相通的最大器官,其黏膜不仅是机体与外界联系的重要屏障,也是胃肠道各种功能得以正常维持的基础。胃肠道黏膜屏障功能是胃肠道疾病发生发展的共同病理生理基础。目前,针对胃肠道黏膜,尤其是小肠黏膜仍缺乏深入系统的认识,临床实践中更多关注损伤因子的作用,忽略了黏膜防护的重要性。为提高医务人员对胃肠道黏膜保护的认识,规范黏膜保护剂的应用,中华医学会消化病学分会胃肠激素与黏膜屏障学组制定了我国第一部胃肠道黏膜保护专家共识,于2021年底正式发布。本文针对共识制定的背景、过程和主要内容进行解读,以帮助医务人员提高认识,规范临床诊疗。
    利益冲突:作者声明不存在利益冲突
  • [1] Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans[J]. Gut, 2019, 68: 1516-1526. doi:  10.1136/gutjnl-2019-318427
    [2] 中华医学会消化病学分会胃肠激素与黏膜屏障学组. 胃肠道黏膜保护临床专家共识(2021年, 福州)[J]. 中华消化杂志, 2021, 41: 798-811. doi:  10.3760/cma.j.cn311367-20210930-00524
    [3] Yandrapu H, Sarosiek J. Protective Factors of the Gastric and Duodenal Mucosa: An Overview[J]. Curr Gastroenterol Rep, 2015, 17: 24. doi:  10.1007/s11894-015-0452-2
    [4] Capaldo CT, Powell DN, Kalman D. Layered defense: how mucus and tight junctions seal the intestinal barrier[J]. J Mol Med (Berl), 2017, 95: 927-934. doi:  10.1007/s00109-017-1557-x
    [5] Paone P, Cani PD. Mucus barrier, mucins and gut microbiota: the expected slimy partners?[J]. Gut, 2020, 69: 2232-2243. doi:  10.1136/gutjnl-2020-322260
    [6] Allam-Ndoul B, Castonguay-Paradis S, Veilleux A. Gut Microbiota and Intestinal Trans-Epithelial Permeability[J]. Int J Mol Sci, 2020, 21: 6402。 doi:  10.3390/ijms21176402
    [7] Wirth HP, Yang M. Different Pathophysiology of Gastritis in East and West?A Western Perspective[J]. Inflamm Intest Dis, 2016, 1: 113-122. doi:  10.1159/000446300
    [8] Guzmán-Mejía F, Godínez-Victoria M, Vega-Baurista A, et al. Intestinal Homeostasis under Stress Siege[J]. Int J Mol Sci, 2021, 22: 5095 doi:  10.3390/ijms22105095
    [9] 杨莹韵, 李渊, 张海芳, 等. 北京地区慢性非萎缩性胃炎伴糜烂患者277例的病因及治疗现状[J]. 中华消化杂志, 2021, 41: 27-32. doi:  10.3760/cma.j.cn311367-20210718-00390
    [10] Watanabe T, Fujiwara Y, Chan FKL. Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review[J]. J Gastroenterol, 2020, 55: 481-495. doi:  10.1007/s00535-019-01657-8
    [11] Elting LS, Cooksley C, Chambers M, et al. The burdens of cancer therapy. Clinical and economic outcomes of chemo-therapy-induced mucositis[J]. Cancer, 2003, 98: 1531-1539. doi:  10.1002/cncr.11671
    [12] Chulkina M, Beswick EJ, Pinchuk IV. Role of PD-L1 in Gut Mucosa Tolerance and Chronic Inflammation[J]. Int J Mol Sci, 2020, 21: 9165. doi:  10.3390/ijms21239165
    [13] Gyires K, Laszlo SB, Lazar B, et al. Similar and Distinct Mechanisms in the Protective Processes of Upper and Lower Gastrointestinal Tract[J]. Curr Pharm Des, 2018, 24: 1936-1946. doi:  10.2174/1381612824666180516101531
    [14] Xiong L, Huang X, Li L, et al. Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: a prospective randomized study[J]. Dig Liver Dis, 2015, 47: 280-284. doi:  10.1016/j.dld.2015.01.005
    [15] Kuramoto T, Umegaki E, Nouda S, et al. Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflam-matory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study[J]. BMC Gastroenterol, 2013, 13: 85.
    [16] 韩涛涛, 陈楚岩, 王静, 等. 瑞巴派特对非甾体抗炎药相关小肠黏膜损伤的保护机制[J]. 中华消化杂志, 2021, 41: 183-189.
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出版历程
  • 收稿日期:  2022-05-06
  • 录用日期:  2022-06-06
  • 网络出版日期:  2022-06-10
  • 刊出日期:  2022-09-30

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