非小细胞肺癌免疫检查点抑制剂治疗进展

王硕; 邓云天; 彭欢; 张向峰

doi:10.12290/xhyxzz.2022-0151

非小细胞肺癌免疫检查点抑制剂治疗进展

doi: 10.12290/xhyxzz.2022-0151

王硕¹,
邓云天¹,
彭欢¹,
张向峰^2, ,

1.
重庆医科大学第一临床学院，重庆 400016
2.
首都医科大学附属北京安贞医院呼吸与危重症科，北京 100029

详细信息

通讯作者:
张向峰, E-mail：xfzh20008@163.com

中图分类号: R734; R453
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出版历程
- 收稿日期: 2022-03-26
- 录用日期: 2022-05-27
- 网络出版日期: 2022-08-09
- 刊出日期: 2023-03-30

Progress in the Treatment of Non-small Cell Lung Cancer with Immune Checkpoint Inhibitors

1.
First Clinical College, Chongqing Medical University, Chongqing 400016, China
2.
Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

More Information

Corresponding author: ZHANG Xiangfeng, E-mail: xfzh20008@163.com

摘要

摘要: 肺癌是全球范围内发病率及死亡率极高的恶性肿瘤，其中以非小细胞肺癌(non-small cell lung cancer，NSCLC)最为常见。NSCLC的传统治疗主要依靠化学药物，近年来免疫治疗成为NSCLC治疗的热点，并取得了令人瞩目的进展。大量新型生物免疫制剂被开发并应用于临床，其中免疫检查点抑制剂的应用最广、疗效最为肯定。本文将对近年NSCLC免疫治疗生物标志物研究现状及进展进行阐述，以期提高免疫治疗精准度，更好地指导NSCLC患者的个体化治疗。
- 非小细胞肺癌 /
- 免疫治疗 /
- CTLA-4 /
- PD-1 /
- PD-L1
Abstract: Lung cancer is a malignant tumor with high incidence rate and mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common malignancy. The traditional treatment of NSCLC mainly depends on chemical drugs. In recent years, immunotherapy has become a hot spot in the treatment of NSCLC and made remarkable progress. The overall objective remission rate of immunotherapy for NSCLC patients is about 20%. A large number of new biological immune agents have been developed and applied in clinic. Among them, immune checkpoint inhibitor (ICI) has the widest application and the most positive effect on NSCLC. This paper summarizes the research status and progress of immunotherapy biomarkers of NSCLC in recent years, with the hope of improving the accuracy of immunotherapy and better guiding individualized treatment of NSCLC patients.
- non-small cell lung cancer /
- immunotherapy /
- CTLA-4 /
- PD-1 /
- PD-L1
注释:

作者贡献：王硕负责文献检索、论文撰写及修订；邓云天、彭欢负责论文选题及修订；张向峰负责论文审校。

利益冲突：所有作者均声明不存在利益冲突

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参考文献(64)

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非小细胞肺癌免疫检查点抑制剂治疗进展

doi: 10.12290/xhyxzz.2022-0151

通讯作者:
张向峰, E-mail：xfzh20008@163.com

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Progress in the Treatment of Non-small Cell Lung Cancer with Immune Checkpoint Inhibitors

Corresponding author: ZHANG Xiangfeng, E-mail: xfzh20008@163.com

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非小细胞肺癌免疫检查点抑制剂治疗进展

doi: 10.12290/xhyxzz.2022-0151

通讯作者: 张向峰, E-mail：xfzh20008@163.com

计量

出版历程

Progress in the Treatment of Non-small Cell Lung Cancer with Immune Checkpoint Inhibitors

Corresponding author: ZHANG Xiangfeng, E-mail: xfzh20008@163.com

计量

出版历程

目录

通讯作者:
张向峰, E-mail：xfzh20008@163.com