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肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展

苏鹏飞,  于健春

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文章导航 > 协和医学杂志  > 2022 >  13(3): 480-486
苏鹏飞, 于健春. 肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展[J]. 协和医学杂志, 2022, 13(3): 480-486. doi: 10.12290/xhyxzz.2021-0605
引用本文: 苏鹏飞, 于健春. 肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展[J]. 协和医学杂志, 2022, 13(3): 480-486. doi: 10.12290/xhyxzz.2021-0605
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SU Pengfei, YU Jianchun. Progress in the Research on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 480-486. doi: 10.12290/xhyxzz.2021-0605
Citation: SU Pengfei, YU Jianchun. Progress in the Research on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 480-486. doi: 10.12290/xhyxzz.2021-0605
shu

肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展

doi: 10.12290/xhyxzz.2021-0605

  • 中国医学科学院北京协和医院基本外科, 北京 100730

基金项目: 

北京市科学技术委员会基金 D171100006517002

详细信息
    通讯作者:

    于健春, E-mail：yu-jch@163.com

  • 中图分类号: R730.5

Progress in the Research on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors

  • Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

Beijing Municipal Commission of Science and Technology Foundation D171100006517002

More Information

    摘要
  • 摘要: 肿瘤耐药的产生是肿瘤细胞与肿瘤微环境(tumor microenvironment, TME)相互作用的结果, 肿瘤相关巨噬细胞(tumor-associated macrophages, TAMs)是TME中的主要免疫细胞, 在炎症微环境和肿瘤细胞的恶性表型之间发挥桥梁作用, 与肿瘤耐药和疾病进展密切相关, 其中M2型TAMs浸润则预示着不良的临床结局。本文主要针对TAMs参与肿瘤耐药的作用机制和治疗进展进行综述, 以期为减少肿瘤耐药、增强抗肿瘤治疗疗效提供参考。
    Abstract: The development of drug-resistance is the interactional result between tumor cells and tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the main immune cells in TME, and act as the bridge between the inflammatory microenviroment and malignant phenotype of tumor cells. They are closely related to drug-resistance and tumor progression, and the infiltration of M2 macrophages indicates a poor clinical outcome. This paper reviews the progress in research of the role of TAMs in drug-resistance and treatment of tumors, providing references for decreasing drug-resistance and increasing the curative effects.
    作者贡献：苏鹏飞、于健春共同参与论文选题；苏鹏飞负责文献检索及论文撰写；于健春负责论文修订。
    利益冲突：所有作者均声明不存在利益冲突
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出版历程
  • 收稿日期:  2021-08-20
  • 录用日期:  2021-10-12
  • 网络出版日期:  2022-04-12
  • 刊出日期:  2022-05-30

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