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摘要: 银屑病是一种慢性复发性疾病, 易反复发作, 迁延不愈, 严重影响患者的生活质量。银屑病复发的诱因多样, 包括精神压力、环境、生活方式、内分泌等多种因素。银屑病复发的免疫机制复杂, 组织常驻记忆T细胞可能在银屑病的免疫记忆中发挥重要作用。明确银屑病复发的危险因素及机制, 可为临床上预防和治疗银屑病反复发作及病情加重提供依据。阻断组织常驻记忆T细胞功能可能为预防银屑病复发的新思路。Abstract: Psoriasis is a kind of chronic recurrent disease, which is easy to recur and protract. It has a severe impact on the life quality of patients. There are multiple factors for the relapse of psoriasis, such as stress, environment, life-style, endocrine and so on. The immunological mechanism of the recurrence of psoriasis is complex. Tissue-resident memory T cells (TRM) may play an important role in the immunological memory of psoriasis. To define the risk factors and the potential pathogenesis of the recurrence of psoriasis can provide basis for the clinical prevention of recurrence and aggravation of psoriasis. To block the function of TRM might open new avenues for preventing the recurrence of psoriasis.
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Key words:
- psoriasis /
- recurrence /
- risk factor /
- pathogenesis /
- T lymphocytes
作者贡献:刘晓涵负责文献资料收集、分析及论文撰写;晋红中负责论文构思及审校。利益冲突:所有作者均声明不存在利益冲突 -
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