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胰腺癌循环肿瘤细胞检测技术及临床应用前景

杨笑盈,  秦骋,  赵邦博,  李天浩,  曹洪滔,  王维斌

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文章导航 > 协和医学杂志  > 2021 >  12(5): 768-773
杨笑盈, 秦骋, 赵邦博, 李天浩, 曹洪滔, 王维斌. 胰腺癌循环肿瘤细胞检测技术及临床应用前景[J]. 协和医学杂志, 2021, 12(5): 768-773. doi: 10.12290/xhyxzz.2020-0005
引用本文: 杨笑盈, 秦骋, 赵邦博, 李天浩, 曹洪滔, 王维斌. 胰腺癌循环肿瘤细胞检测技术及临床应用前景[J]. 协和医学杂志, 2021, 12(5): 768-773. doi: 10.12290/xhyxzz.2020-0005
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YANG Xiaoying, QIN Cheng, ZHAO Bangbo, LI Tianhao, CAO Hongtao, WANG Weibin. Detection Technology and Prospects of Clinical Application of Circulating Tumor Cells in Pancreatic Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(5): 768-773. doi: 10.12290/xhyxzz.2020-0005
Citation: YANG Xiaoying, QIN Cheng, ZHAO Bangbo, LI Tianhao, CAO Hongtao, WANG Weibin. Detection Technology and Prospects of Clinical Application of Circulating Tumor Cells in Pancreatic Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(5): 768-773. doi: 10.12290/xhyxzz.2020-0005
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胰腺癌循环肿瘤细胞检测技术及临床应用前景

doi: 10.12290/xhyxzz.2020-0005

  • 中国医学科学院 北京协和医学院 北京协和医院基本外科，北京 100730

基金项目: 

国家自然科学基金 81773215

详细信息
    通讯作者:

    王维斌  电话：010-69152610，E-mail: wwb_xh@163.com

  • 中图分类号: R735.9

Detection Technology and Prospects of Clinical Application of Circulating Tumor Cells in Pancreatic Cancer

  • Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National Natural Science Foundation of China 81773215

More Information
    Corresponding author: WANG Weibin  Tel: 86-10-69152610, E-mail: wwb_xh@163.com

    摘要
  • 摘要: 胰腺癌是消化系统高度恶性的肿瘤之一，其早期即可发生远处转移，患者生存期较短、预后较差。循环肿瘤细胞(circulating tumor cells, CTCs)是一类可进入血液循环的肿瘤细胞，不仅具有与原发肿瘤细胞相似的特征，且与肿瘤远处转移的关系更为密切。体外定量检测CTCs对胰腺癌的早期诊断、辅助分期、疗效及预后评估均具有重要意义。本文对胰腺癌CTCs富集方法及CTCs检测在胰腺癌筛查、远处转移与预后评估中的应用进行综述。
    Abstract: Pancreatic cancer is one of the highly malignant tumors of the digestive system, and early metastasis is an important reason for its short survival time. Circulating tumor cells (CTCs) are a type of tumor cells that are released into the bloodstream from the primary tumor and/or metastatic sites, which have properties similar to primary tumor cells and are closely related to distant metastasis of tumors. In vitro quantitative detection of CTCs is of great significance in the early diagnosis, auxiliary staging, treatment efficacy, and prognosis evaluation of pancreatic cancer. Here we generally reviewed current research on the CTCs enrichment methods of pancreatic cancer and its application in screening pancreatic cancer and metastasis, and evaluating the prognosis.
    作者贡献：  杨笑盈、秦骋撰写论文初稿；王维斌负责论文设计；赵邦博负责论文修改；李天浩、曹洪滔负责文献查阅工作；所有作者均参与本文修订。
    利益冲突：无
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    • 参考文献(44)
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  • 收稿日期:  2020-12-03
  • 录用日期:  2020-12-28
  • 网络出版日期:  2021-02-05
  • 刊出日期:  2021-09-30

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