长链非编码RNA与肿瘤干细胞

肖楠; 李占峰; 姚建新; 潘志尧; 姚志峰

doi:10.12290/xhyxzz.20190231

长链非编码RNA与肿瘤干细胞

doi: 10.12290/xhyxzz.20190231

肖楠¹,
李占峰¹,
姚建新¹,
潘志尧²,
姚志峰^{1, 3, ,}

1.
江苏联合职业技术学院南京卫生分院医学技术系，南京 210038
2.
浙江大学医学部基础医学院生物化学系，杭州 310058
3.
南京医科大学第二附属医院肿瘤医学中心放射治疗科，南京 210011

详细信息

通讯作者:
姚志峰电话：025-58509711，E-mail：yzf058565@126.com

中图分类号: R73
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- 被引次数: 0
出版历程
- 收稿日期: 2019-10-22
- 录用日期: 2020-04-26
- 刊出日期: 2021-05-30

Long Non-coding RNA and Cancer Stem Cells

1.
Faculty of Medical Technology, Nanjing Health School, Jiangsu United Vocational and Technical College, Nanjing 210038, China
2.
Faculty of Biochemistry, Basic Medicine College, Zhejiang University, Hangzhou 310058, China
3.
Department of Radiotherapy, Center for Oncological Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China

More Information

Corresponding author: YAO Zhifeng Tel: 86-25-58509711, E-mail: yzf058565@126.com

摘要

摘要: 肿瘤包含具有干细胞特性的功能细胞亚群，称为肿瘤干细胞(cancer stem cell，CSC)，这些细胞亚群在肿瘤的发生和发展中起重要作用。长链非编码RNA(long non-coding RNA，lncRNA)是CSC亚群的关键调节因子，具有诱导CSC自我更新、迁移、侵袭、耐药和分化的重要能力。本文对近年来lncRNA在不同CSC发生、维持和调节中的功能及作用机制进行综述，以期通过lncRNA寻找肿瘤治疗新靶点，以选择性消除CSC，最终改善肿瘤患者的预后。
- 长链非编码RNA /
- 肿瘤干细胞 /
- 自我更新 /
- 分化
Abstract: Tumors contain a functional subpopulation of cells that exhibit characteristics of stem cells. This cell subgroup, named cancer stem cell (CSC), plays important roles in the initiation and progression of cancers. As a key regulator of the CSC subgroup, long non-coding RNA (lncRNA) has the important ability to induce self-renewal, migration, invasion, drug resistance and differentiation of CSC. This review summarizes recent research on the functions and mechanisms of lncRNA in the occurrence, maintenance and regulation of different CSC, with the aim of finding new targets for cancer treatment through lncRNA to selectively eliminate CSC and ultimately improve the prognosis of patients with cancer.
- long non-coding RNA /
- cancer stem cell /
- self-renewal /
- differentiation
注释:

作者贡献: 肖楠负责查阅文献、撰写初稿；李占峰、姚建新、潘志尧负责核对文献、提出修改意见；姚志峰负责修订、审核论文。

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参考文献(60)

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长链非编码RNA与肿瘤干细胞

doi: 10.12290/xhyxzz.20190231

通讯作者:
姚志峰电话：025-58509711，E-mail：yzf058565@126.com

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Long Non-coding RNA and Cancer Stem Cells

Corresponding author: YAO Zhifeng Tel: 86-25-58509711, E-mail: yzf058565@126.com

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留言板

长链非编码RNA与肿瘤干细胞

doi: 10.12290/xhyxzz.20190231

通讯作者: 姚志峰 电话：025-58509711，E-mail：yzf058565@126.com

计量

出版历程

Long Non-coding RNA and Cancer Stem Cells

Corresponding author: YAO Zhifeng Tel: 86-25-58509711, E-mail: yzf058565@126.com

计量

出版历程

目录

通讯作者:
姚志峰电话：025-58509711，E-mail：yzf058565@126.com