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高尿酸血症与其他代谢异常的相关性

刘淑芬,  李源杰,  黄程锦,  王琦,  秦薇,  盖小荣,  沈瑛,  邱玲,  曾学军

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文章导航 > 协和医学杂志  > 2010 >  1(2): 150-154
刘淑芬, 李源杰, 黄程锦, 王琦, 秦薇, 盖小荣, 沈瑛, 邱玲, 曾学军. 高尿酸血症与其他代谢异常的相关性[J]. 协和医学杂志, 2010, 1(2): 150-154.
引用本文: 刘淑芬, 李源杰, 黄程锦, 王琦, 秦薇, 盖小荣, 沈瑛, 邱玲, 曾学军. 高尿酸血症与其他代谢异常的相关性[J]. 协和医学杂志, 2010, 1(2): 150-154.
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Shu-fen LIU, Yuan-jie LI, Cheng-jin HUANG, Qi WANG, Wei QIN, Xiao-rong GAI, Ying SHEN, Ling QIU, Xue-jun ZENG. Association between Hyperuricemia and Other Metabolism Dysfunctions[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(2): 150-154.
Citation: Shu-fen LIU, Yuan-jie LI, Cheng-jin HUANG, Qi WANG, Wei QIN, Xiao-rong GAI, Ying SHEN, Ling QIU, Xue-jun ZENG. Association between Hyperuricemia and Other Metabolism Dysfunctions[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(2): 150-154.
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高尿酸血症与其他代谢异常的相关性

  • 1.

    中国医学科学院 北京协和医学院 北京协和医院 普通内科, 北京 100730

  • 2.

    中国医学科学院 北京协和医学院 北京协和医院 内科, 北京 100730

  • 3.

    中国医学科学院 北京协和医学院 北京协和医院 健康医学部, 北京 100730

  • 4.

    中国医学科学院 北京协和医学院 北京协和医院 检验科, 北京 100730

详细信息
    通讯作者:

    曾学军 电话:010-88068520, E-mail:zxuejun@yahoo.com

  • 中图分类号: R589

Association between Hyperuricemia and Other Metabolism Dysfunctions

  • 1.

    Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of MedicalSciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of MedicalSciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Physical Examination Center, Peking Union Medical College Hospital, Chinese Academy of MedicalSciences & Peking Union Medical College, Beijing 100730, China

  • 4.

    Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of MedicalSciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要:   目的  探讨高尿酸血症与其他代谢异常的相关性, 指导临床对高尿酸血症患者的诊治。  方法  对2008年本院2074名健康体检人群进行横断面调查, 描述高尿酸血症和其他代谢异常在健康体检人群的患病率, 通过双变量分析和Logistic多元回归分析, 探讨高尿酸血症和其他代谢异常的相关性。  结果  本组人群总高尿酸血症患病率为14.27%, 男性为21.36%, 女性为11.48%;其他各代谢异常的患病率分别为肥胖12.07%, 高血压24.70%, 空腹高血糖19.46%, 高总胆固醇血症36.38%, 高甘油三酯血症28.68%, 低高密度脂蛋白-胆固醇血症33.80%, 高低密度脂蛋白-胆固醇血症35.25%, 高非高密度脂蛋白-胆固醇血症22.59%, 脂肪肝40.28%;高尿酸血症组其他代谢异常的患病率均较非高尿酸血症组高, 调整年龄、性别后两组比较差异仍有统计学意义; 双变量相关分析显示血清尿酸值与年龄、性别、体重指数、收缩压、舒张压、高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇、总胆固醇、甘油三酯、非高密度脂蛋白-胆固醇、空腹血糖、肌酐、脂肪肝均具有显著相关性。多元Logistic回归分析发现血清尿酸水平与肥胖、高血压、低高密度脂蛋白-胆固醇、高甘油三酯、脂肪肝独立相关。  结论  高尿酸血症与肥胖、高血压、血脂紊乱、脂肪肝等代谢异常独立相关, 其可能增加上述代谢异常的发生风险。
    Abstract:   Objective  To explore the association between hyperuricemia and other metabolism dysfunctions.  Methods  A cross-sectional study in 2074 health examination subjects in our hospital in 2008. We calculated the prevalences of hyperuricemia and other metabolism dysfunctions and explored the association between hyperuricemia and other metabolism dysfunctions using bivariate correlation analysis and Logistic multiple analysis.  Results  The prevalence were as follows:hyperuricemia is 14.27%, obesity 12.07%, hypertension 24.70%, fasting hyperglycaemia 19.46%, hypercholesteremia 36.38%, hypertriglyceridemia 28.68%, fatty liver 40.28%. The prevalences of metabolism dysfunctions were significantly higher in hyperuricemia group than in non-hyperuricemia group, and such significant differences still existed after having been adjusted with age. Bivariate correlation analysis showed that hyperuricemia was significantly correlated with age, gender, body mass index, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglyceride, non-high-density lipoprotein cholesterol, glucose, creatinine, and fatty liver. Logistic multiple regression analysis showed that the level of serum uric acid was independently associated with obesity, hypertension, low-density lipoprotein cholesterol, hypertriglyceridemia, and fatty liver.  Conclusions  Hyperuricemia is independently associated with obesity, hypertension, hypertriglyceridemia, and fatty liver. It can increase the risk of these metabolic disorders.
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  • 图  1  非高尿酸血症与高尿酸血症患者各代谢异常的比较

    TC、TG、HDL-C、LDL-C、nonHDL-C:同表 2; 与非高尿酸组比较, * *P < 0. 01

    下载: 全尺寸图片 幻灯片

    表  1  各年龄组男女性高尿酸血症患病情况

    表  2  各代谢异常在男女性及总人群的患病情况

    表  3  调整年龄和性别后高尿酸血症与各代谢异常的关系

    表  4  高尿酸血症的独立相关危险因素(Logistic多元回归分析)
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  • 收稿日期:  2010-07-26
  • 刊出日期:  2010-10-30

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