The Role of CEACAM1 in Metabolic Dysfunction-associated Steatotic Liver Disease

Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) is a transmembrane protein of the immunoglobulin superfamily,which is involved in mediating cell adhesion,tissue metastasis,control of immune response,and metabolic homeostasis.Studies have shown that CEACAM1 plays a protective role in the liver by promoting insulin clearance and preventing fat deposition.The down-regulation of the CEACAM1 expression level leads to a vicious cycle of insulin resistance and aggravates metabolic disorders.Because CEACAM1 is critical in controlling metabolic dysfunction-associated steatotic liver disease (MASLD),stimulating its pathway or regulating its expression level is expected to be a new therapeutic approach for MASLD.In this paper,we summarize the research progress of CEACAM1 in MASLD.